Detalhe da pesquisa
1.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Nat Chem Biol
; 13(9): 943-950, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28671682
2.
Translating slow-binding inhibition kinetics into cellular and in vivo effects.
Nat Chem Biol
; 11(6): 416-23, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894085
3.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
4.
Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.
Bioorg Med Chem Lett
; 25(16): 3301-6, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099541
5.
Avibactam is a covalent, reversible, non-ß-lactam ß-lactamase inhibitor.
Proc Natl Acad Sci U S A
; 109(29): 11663-8, 2012 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22753474
6.
Kinetics of avibactam inhibition against Class A, C, and D ß-lactamases.
J Biol Chem
; 288(39): 27960-71, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23913691
7.
Exploitation of structural and regulatory diversity in glutamate racemases.
Nature
; 447(7146): 817-22, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17568739
8.
High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics.
SLAS Discov
; 26(4): 503-517, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33430712
9.
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.
ACS Chem Biol
; 16(11): 2228-2243, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582690
10.
Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models.
Mol Cancer Ther
; 20(8): 1367-1377, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045230
11.
A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.
SLAS Discov
; 26(4): 547-559, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780296
12.
Conservation of the structure and function of bacterial tryptophan synthases.
IUCrJ
; 6(Pt 4): 649-664, 2019 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31316809
13.
Targeted protein degradation and the enzymology of degraders.
Curr Opin Chem Biol
; 44: 47-55, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29885948
14.
A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.
Chem Sci
; 8(5): 3434-3443, 2017 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28507715
15.
Advances in Protein Degradation.
SLAS Discov
; 26(4): 471-473, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33780295
16.
Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.
Chem Sci
; 7(9): 5945-5954, 2016 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27547299
17.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection.
ACS Chem Biol
; 11(2): 363-74, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26640968
18.
Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-l-alanine ligase.
Biochim Biophys Acta
; 1698(2): 167-74, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15134649
19.
Development of an LC-MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis.
J Pharm Biomed Anal
; 35(4): 817-28, 2004 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15193726
20.
Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection.
PLoS One
; 9(3): e90382, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24595353