Detalhe da pesquisa
1.
A Structure-Activity Investigation of the Fungal Metabolite (-)-TAN-2483B: Inhibition of Bruton's tyrosine kinase.
Chemistry
; : e202401051, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629656
2.
Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK.
BMC Cancer
; 21(1): 136, 2021 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549048
3.
Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay.
Bioorg Med Chem
; 39: 116160, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33901770
4.
A single discrete Rab5-binding site in phosphoinositide 3-kinase ß is required for tumor cell invasion.
J Biol Chem
; 294(12): 4621-4633, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659094
5.
Variable-Length Ester-Based Staples for α-Helical Peptides by Using A Double Thiol-ene Reaction.
Chemistry
; 26(47): 10826-10833, 2020 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32232881
6.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
7.
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay.
Bioorg Med Chem
; 26(12): 3406-3413, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29776832
8.
Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.
Biochem J
; 474(13): 2261-2276, 2017 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28526744
9.
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay.
Bioorg Med Chem
; 25(1): 440-449, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27856238
10.
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.
Bioorg Med Chem
; 25(20): 5859-5874, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28958845
11.
Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis.
Platelets
; 28(8): 799-811, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28277064
12.
Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine.
Biochim Biophys Acta
; 1850(9): 1772-80, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25907332
13.
Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed.
J Struct Biol
; 192(3): 539-544, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26522274
14.
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.
Bioorg Med Chem
; 23(13): 3796-808, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25890698
15.
Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.
Biochem Soc Trans
; 42(1): 120-4, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450638
16.
Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents.
Bioorg Med Chem
; 22(2): 711-20, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24387866
17.
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3).
Bioorg Med Chem
; 22(3): 967-77, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24411201
18.
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).
Bioorg Med Chem
; 22(3): 1029-39, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24398380
19.
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).
Bioorg Med Chem
; 21(24): 7595-603, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24262887
20.
Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity.
Anal Bioanal Chem
; 405(8): 2515-24, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23314482