RESUMO
A combination of 150 mug. d-norgestrel with 30 mug. ethinyl oestradiol was administered to 120 women for a total of 767 cycles. No pregnancies occurred and cycle control was good, 99% of the cycles being within the range of 28 plus or minus 3 days. Breakthrough bleeding occurred in 7.2% of the cycles, spotting in 8.9% and amenorphoea in 0.8%. Side-effects were minimal.
Assuntos
Anticoncepcionais Orais Hormonais/administração & dosagem , Anticoncepcionais Orais/administração & dosagem , Etinilestradiol/administração & dosagem , Norgestrel/administração & dosagem , Adolescente , Adulto , Ensaios Clínicos como Assunto , Combinação de Medicamentos , Feminino , Humanos , Menstruação/efeitos dos fármacos , Gravidez/efeitos dos fármacosAssuntos
Clomifeno/uso terapêutico , Estrogênios/urina , Hormônio Foliculoestimulante/urina , Hormônio Luteinizante/urina , Adulto , Amenorreia/fisiopatologia , Citratos/farmacologia , Citratos/uso terapêutico , Clomifeno/administração & dosagem , Clomifeno/farmacologia , Feminino , Hormônio Foliculoestimulante/metabolismo , Humanos , Infertilidade Feminina/tratamento farmacológico , Cariotipagem , Ovulação/efeitos dos fármacos , Testes de Função Hipofisária , Gravidez , Taxa Secretória/efeitos dos fármacosAssuntos
Clomifeno/uso terapêutico , Gonadotropinas/uso terapêutico , Infertilidade/tratamento farmacológico , Amenorreia/tratamento farmacológico , Clomifeno/administração & dosagem , Clomifeno/efeitos adversos , Feminino , Gonadotropinas/administração & dosagem , Humanos , Infertilidade Feminina/tratamento farmacológico , Infertilidade Masculina/tratamento farmacológico , Masculino , Ovulação/efeitos dos fármacos , Gravidez , Gravidez Múltipla , EspermatozoidesRESUMO
Apparently normal but infertile women were treated by artificial insemination using fresh donor semen. In 228 couples in which the male partner was azoospermic the average monthly conception rate was 13.3% and the 12-month cumulative rate was 82.2% (SE 2.7%). In 116 couples in which the partner was oligospermic the monthly rate was 8.7% and the 12-month rate 66.6% (SE 5.0%, P less than 0.01). Previous smaller studies have given rise to conflicting or inconclusive results, but the reduced conception rates in the partners of oligospermic men in this large study suggests that unexplained female factors, discussed in the paper, contribute to their infertility in up to a third of patients.
Assuntos
Infertilidade Feminina , Infertilidade Masculina , Inseminação Artificial Heteróloga , Inseminação Artificial , Adulto , Feminino , Humanos , Masculino , Oligospermia , GravidezRESUMO
Norgestrel in a dose of 50 mug. was administered daily to 188 women during 2,250 menstrual cycles. Only two pregnancies occurred because of failure of the method, giving a failure rate of 1.1 pregnancies per 100 woman-years. The method was acceptable to most of the subjects, and side-effects, other than menstrual irregularity, were minimal; 68% of the cycles were 28 +/-5 days in length and 21% were less than 23 days. There did not appear to be any increased incidence of amenorrhoea. The antifertility action of continuous administration of low doses of progestogen may be due to an effect on corpus luteum function, in addition to the effects on cervical mucus, endometrium, and tubal transport of ova. The optimum dose of norgestrel appears to be in the range of 50-75 mug./day.