Detalhe da pesquisa
1.
Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy.
Hum Mol Genet
; 22(16): 3227-38, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23595883
2.
Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death.
Neurobiol Dis
; 50: 160-70, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089356
3.
Meclizine is neuroprotective in models of Huntington's disease.
Hum Mol Genet
; 20(2): 294-300, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20977989
4.
Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
Hum Mol Genet
; 20(12): 2344-55, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21447599
5.
Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative.
Hum Mol Genet
; 20(21): 4258-67, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840924
6.
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.
J Neurosci
; 30(32): 10844-50, 2010 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20702713
7.
Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease.
J Biol Chem
; 284(27): 18167-73, 2009 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433866
8.
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.
J Neurosci
; 27(26): 6972-83, 2007 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-17596446
9.
Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells.
Chem Biol
; 13(7): 765-70, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16873024
10.
HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.
PLoS One
; 10(8): e0134465, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26295712
11.
Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis.
BMC Neurosci
; 5: 57, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588329
12.
Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.
J Biol Chem
; 281(29): 20483-93, 2006 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16714284
13.
Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.
Hum Mol Genet
; 15(12): 2015-24, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16687439
14.
HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
Hum Mol Genet
; 14(19): 2871-80, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16115812
15.
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.
Hum Mol Genet
; 12(5): 497-508, 2003 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12588797
16.
Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.
Hum Mol Genet
; 11(19): 2233-41, 2002 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12217951