Detalhe da pesquisa
1.
NMR Data-Driven Docking of HDM2-Inhibitor Complexes.
Chembiochem
; 23(6): e202100570, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104390
2.
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.
Bioorg Med Chem Lett
; 49: 128314, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34391891
3.
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.
Bioorg Med Chem Lett
; 42: 128046, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33865969
4.
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors.
Bioorg Med Chem Lett
; 47: 128214, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34166782
5.
Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 30(1): 126715, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757666
6.
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.
Bioorg Med Chem Lett
; 29(18): 2575-2580, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31416665
7.
Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016.
J Comput Aided Mol Des
; 32(1): 113-127, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28913710
8.
Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.
J Comput Aided Mol Des
; 32(1): 129-142, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986733
9.
Corrigendum to "Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow" [Bioorg. Med. Chem. Lett. 29 (2019) 2575-2580].
Bioorg Med Chem Lett
; 30(16): 127363, 2020 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591133
10.
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 4): 404-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505407
11.
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.
ACS Med Chem Lett
; 13(4): 734-741, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35450359
12.
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.
J Med Chem
; 65(8): 6001-6016, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35239336
13.
1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka.
Bioorg Med Chem Lett
; 21(3): 932-5, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21227690
14.
Structural insights on ligand recognition at the human leukotriene B4 receptor 1.
Nat Commun
; 12(1): 2971, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34016973
15.
Identification of Potent Reverse Indazole Inhibitors for HPK1.
ACS Med Chem Lett
; 12(3): 459-466, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738073
16.
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
ACS Med Chem Lett
; 12(4): 653-661, 2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859804
17.
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
SLAS Discov
; 26(1): 88-99, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32844715
18.
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
ACS Med Chem Lett
; 12(9): 1435-1440, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531952
19.
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(21): 16213-16241, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714078
20.
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.
J Med Chem
; 64(8): 5137-5156, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33797901