Detalhe da pesquisa
1.
Identification and targeting of a unique NaV1.7 domain driving chronic pain.
Proc Natl Acad Sci U S A
; 120(32): e2217800120, 2023 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37498871
2.
Nociceptors are functionally male or female: from mouse to monkey to man.
Brain
; 2024 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38829801
3.
Two-Step Membrane Binding of NDPK-B Induces Membrane Fluidity Decrease and Changes in Lipid Lateral Organization and Protein Cluster Formation.
Langmuir
; 32(48): 12923-12933, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27934520
4.
Protein "amyloid-like" networks at the phospholipid membrane formed by 4-hydroxy-2-nonenal-modified mitochondrial creatine kinase.
Mol Membr Biol
; 32(1): 1-10, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25865250
5.
Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain.
bioRxiv
; 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38766071
6.
Aptamers Targeting Hallmark Proteins of Neurodegeneration.
Nucleic Acid Ther
; 32(4): 235-250, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35452303
7.
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Sci Rep
; 12(1): 8140, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581326
8.
Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape.
RSC Chem Biol
; 2(4): 1158-1166, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458829
9.
In Silico Targeting of the Long Noncoding RNA MALAT1.
ACS Med Chem Lett
; 12(6): 915-921, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141069
10.
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Sci Transl Med
; 13(619): eabh1314, 2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34757807
11.
Corrigendum: Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
Front Mol Neurosci
; 13: 45, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32300293
12.
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.
ACS Chem Biol
; 15(11): 2854-2859, 2020 11 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33044808
13.
1H, 15N and 13C backbone assignment of apo TDP-43 RNA recognition motifs.
Biomol NMR Assign
; 13(1): 163-167, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30694439
14.
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief.
Channels (Austin)
; 13(1): 498-504, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31680630
15.
Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
Front Mol Neurosci
; 12: 301, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31920533
16.
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
ACS Chem Biol
; 14(9): 2006-2013, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31241884
17.
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
ACS Chem Neurosci
; 10(12): 4834-4846, 2019 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31697467
18.
Targeting the CaVα-CaVß interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Pain
; 160(7): 1644-1661, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30933958
19.
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
Channels (Austin)
; 12(1): 219-227, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30081699
20.
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.
Pain
; 159(10): 2115-2127, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29847471