Detalhe da pesquisa
1.
Activating mitofusins interrupts mitochondrial degeneration and delays disease progression in SOD1 mutant amyotrophic lateral sclerosis.
Hum Mol Genet
; 32(7): 1208-1222, 2023 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36416308
2.
Mitochondrial Dysfunction and Pharmacodynamics of Mitofusin Activation in Murine Charcot-Marie-Tooth Disease Type 2A.
J Pharmacol Exp Ther
; 383(2): 137-148, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36507849
3.
Correcting mitochondrial fusion by manipulating mitofusin conformations.
Nature
; 540(7631): 74-79, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775718
4.
The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATc1 axis.
J Biol Chem
; 295(19): 6629-6640, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32165499
5.
G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.
J Mol Cell Cardiol
; 121: 60-68, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29969579
6.
Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.
Arterioscler Thromb Vasc Biol
; 33(10): 2415-24, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23950144
7.
A human mitofusin 2 mutation can cause mitophagic cardiomyopathy.
Elife
; 122023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37910431
8.
Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events.
Front Cell Dev Biol
; 10: 868465, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35646911
9.
Mitochondria Clumping vs. Mitochondria Fusion in CMT2A Diseases.
Life (Basel)
; 12(12)2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36556475
10.
Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity.
J Med Chem
; 64(17): 12506-12524, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34415150
11.
Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A.
Elife
; 92020 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33074106
12.
Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases.
J Med Chem
; 63(13): 7033-7051, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32506913
13.
Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure.
ESC Heart Fail
; 7(4): 1571-1584, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32352228
14.
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.
J Clin Invest
; 129(4): 1756-1771, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30882371
15.
GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion.
Cell Death Discov
; 4: 25, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29531822
16.
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.
Science
; 360(6386): 336-341, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29674596
17.
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence.
Cell Metab
; 26(6): 872-883.e5, 2017 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107503
18.
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.
J Clin Invest
; 131(2)2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33463548
19.
Correction to "Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases".
J Med Chem
; 63(17): 10086, 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32822172
20.
Good at Heart: Preserving Cardiac Metabolism during aging.
Curr Diabetes Rev
; 12(2): 90-9, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26201429