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1.
Nutr Cancer ; 73(3): 420-432, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32340493

RESUMO

Malnutrition is prevalent in gastrointestinal (GI) cancer patients, possibly due to inflammation and altered fatty acids (FA). There is a lack of research describing nutritional decline in these patients during chemotherapy. We described changes in nutritional, inflammatory, and FA status over time and factors relating to change in nutritional status according to tumor presence in 41 GI cancer patients undergoing first-line treatment over four chemotherapy visits, using linear mixed effects models. At baseline, 53% of patients were malnourished. Over time, there was a decrease in the proportion of malnourished vs. well-nourished individuals (ß= -0.564, p < 0.01). Median concentrations of plasma linoleic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, total n-3, total n-6 and total plasma phospholipid FA increased over time. Changes over time in nutritional status based on weight (p < 0.001), fat free mass (FFM) measured by bioelectrical impedance analysis (BIA, p = 0.02), and skinfold anthropometry (FSA, p = 0.04) were significantly dependent on tumor presence. There were positive associations between weight and total n-3 (ß = 0.02, p < 0.01), FFM and IL-6 (BIA, ß = 0.028, p = 0.02; FSA, ß = 0.03, p = 0.02), and FFM and total n-6 (BIA, ß = 0.003, p = 0.01). Changes in nutritional status during chemotherapy were negatively impacted by tumor presence, and were associated with increasing concentrations of cytokines and FA.


Assuntos
Neoplasias Colorretais , Desnutrição , Composição Corporal , Neoplasias Colorretais/complicações , Neoplasias Colorretais/tratamento farmacológico , Impedância Elétrica , Ácidos Graxos , Humanos , Estado Nutricional
2.
Nutr Cancer ; 65(2): 234-9, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23441610

RESUMO

The scored Patient-Generated Subjective Global Assessment tool (PG-SGA), regarded as the most appropriate means of identifying malnutrition in cancer patients, is often challenging to implement in a busy outpatient setting. We assessed the validity of an abridged version of the PG-SGA (abPG-SGA), which forgoes the physical examination, and compared its usefulness in discerning malnutrition to the full PG-SGA and Malnutrition Screening Tool (MST). The nutritional status of 90 oncology outpatients receiving chemotherapy was assessed according to SGA global rating, PG-SGA, and MST. Receiver operating characteristic (ROC) curves were generated to estimate the sensitivity and specificity of various cut-off scores for malnutrition. Thirty-six percent of patients were malnourished (SGA). The abPG-SGA yielded 94% sensitivity and 78% specificity and area under the curve (AUC) = 0.956, which was slightly lower than PG-SGA (97% sensitivity, 86% specificity, AUC = 0.967) and higher than MST (81% sensitivity, 72% specificity, AUC = 0.823). Patient reported symptoms included loss of appetite (30%), altered taste (31%), fatigue (30%), and decreased ability to perform activities of daily living (53%). In conclusion, the abPG-SGA is a practical, informative and valid tool for detecting malnutrition in the outpatient oncology setting.


Assuntos
Desnutrição/diagnóstico , Neoplasias/complicações , Avaliação Nutricional , Adulto , Assistência Ambulatorial/métodos , Área Sob a Curva , Fadiga/etiologia , Transtornos da Alimentação e da Ingestão de Alimentos/etiologia , Feminino , Humanos , Masculino , Desnutrição/etiologia , Pessoa de Meia-Idade , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Pacientes Ambulatoriais , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
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