Detalhe da pesquisa
1.
Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway.
Brain
; 146(1): 149-166, 2023 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298632
2.
Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology.
Neurobiol Dis
; 181: 106116, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054900
3.
Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.
Brain
; 144(4): 1167-1182, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33842937
4.
THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency.
Neurobiol Dis
; 155: 105398, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019997
5.
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
Int J Mol Sci
; 22(13)2021 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34201785
6.
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo.
Neurobiol Dis
; 134: 104614, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31605779
7.
The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease.
Eur J Neurosci
; 49(3): 339-363, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30269383
8.
Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.
Brain
; 141(2): 535-549, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29253129
9.
The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.
Brain
; 141(5): 1434-1454, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534157
10.
Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
Hum Mol Genet
; 24(6): 1563-73, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398949
11.
Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.
Mol Cell Proteomics
; 8(5): 946-58, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19164277
12.
Zero Echo Time 17O-MRI Reveals Decreased Cerebral Metabolic Rate of Oxygen Consumption in a Murine Model of Amyloidosis.
Metabolites
; 11(5)2021 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33922384
13.
Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.
Hum Mol Genet
; 17(10): 1446-56, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18267960
14.
Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease.
Cell Metab
; 31(3): 503-517.e8, 2020 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130882
15.
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin.
Mol Biol Cell
; 17(4): 1652-63, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16452635
16.
Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models.
Physiol Genomics
; 33(2): 170-9, 2008 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18252803
17.
Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease.
Acta Neuropathol Commun
; 6(1): 104, 2018 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30322407
18.
Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.
Mol Ther Methods Clin Dev
; 5: 259-276, 2017 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28603746
19.
mRNA trans-splicing in gene therapy for genetic diseases.
Wiley Interdiscip Rev RNA
; 7(4): 487-98, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27018401
20.
Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
Neurobiol Aging
; 36(3): 1601.e7-16, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619660