RESUMO
Scedosporium apiospermum is a filamentous fungus that can cause cutaneous or extracutaneous disease. A large number of cases have been published over the last decades, mainly in patients immunocompromised as a result of their disease or treatment. These kinds of infections can progress rapidly and become disseminated, leading to very serious or even fatal complications. We report two new cases of skin infection by Scedosporium apiospermum from our hospital.
Assuntos
Antifúngicos/uso terapêutico , Dermatomicoses/imunologia , Hospedeiro Imunocomprometido , Naftalenos/administração & dosagem , Pirimidinas/administração & dosagem , Scedosporium/isolamento & purificação , Triazóis/administração & dosagem , Abscesso/tratamento farmacológico , Abscesso/cirurgia , Idoso , Dermatomicoses/diagnóstico , Dermatomicoses/tratamento farmacológico , Humanos , Masculino , Scedosporium/efeitos dos fármacos , Terbinafina , VoriconazolRESUMO
BACKGROUND: Cardiovascular risk factors have been assessed with some skin diseases such as alopecia and psoriasis. Recently, a case-control study found that lichen planus (LP) was associated with dyslipidaemia in a large series of patients. However, no data were presented about lipid values in patients and controls. OBJECTIVE: The objective of this case-control study was to evaluate lipid levels in men and women with lichen planus and in healthy controls, excluding lichenoid drug eruption and treatment for LP such as systemic corticosteroids, retinoid acid or methotrexate. PATIENTS AND METHODS: This case-control study included 160 patients, 80 with LP (40 men and 40 women) and 80 controls consecutively admitted to the outpatient clinic in Dermatology department of San Cecilio Hospital, Granada, Spain. RESULTS: Patients with LP presented higher significant triglycerides values (145.9 vs. 101.5 mg/dL P = 0.0007), total cholesterol values (197.7 vs. 178.4 mg/dL P = 0.001), LDL-C values (120.8 vs. 100.9 mg/dL P < 0.0001) and lower HDL-C values (55.3 vs. 61.9 mg/dL P = 0.004) vs. controls. Adjusted OR for dyslipidaemia in patients with LP was 3.03 (95% confidence interval: 1.49-6.17, P = 0.002). CONCLUSION: The results obtained in this study indicate an association between LP and dyslipidaemia. Lipid levels screening in men or women with LP may be useful to detect individuals at risk and start preventive treatment against the development of cardiovascular disease.
Assuntos
Líquen Plano/sangue , Lipídeos/sangue , Adulto , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Cutaneous leishmaniasis is a group of diseases with vast clinical polymorphism produced by protozoa of the genus Leishmania, that is acquired through the bite of sandflies. It is an endemic zoonosis in Spain, being the dog the main reservoir. In our country all forms of leishmaniasis are due to Leishmania infantum species, that usually produces mild lesions in uncovered areas, mainly in children. We report an imported case of cutaneous leishmaniasis in a Senegal patient that presented clinical characteristics unusually different from the typical lesions produced by L. infantum that we are used to evaluate. The lesions were multiple, large, very inflammatory and exudative; these differences may be attributed to the type of endemic leishmania in Senegal: L. major. Given the increase in immigrant population and travels abroad, it is essential for the dermatologist to become familiar with skin diseases of tropical areas that, in the near future, will be more common in daily clinical practice.
Assuntos
Leishmaniose Cutânea/patologia , Migrantes , Adulto , Humanos , Masculino , Senegal/etnologia , EspanhaRESUMO
Sinus histiocytosis with massive lymphadenopathy is an entity that exceptionally appears as a purely cutaneous disease. We described 2 cases of this form with spontaneous involution. Histology showed a polymorphic infiltrate in the dermis and hypodermis composed of large histiocytes with lymphophagocytosis, neutrophils and plasma cells. Immunohistochemical stains demonstrated the positivity of histiocytes for protein S-100 and MAC 387.