Detalhe da pesquisa
1.
Enantio- and Diastereodivergent Cyclopropanation of Allenes by Directed Evolution of an Iridium-Containing Cytochrome.
J Am Chem Soc
; 146(3): 1819-1824, 2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38190322
2.
Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl-Alkenes Catalyzed by Laboratory Evolved P450s.
Chembiochem
; : e202400066, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38567500
3.
Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes.
Chembiochem
; : e202400079, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38477872
4.
A shared mechanistic pathway for pyridoxal phosphate-dependent arginine oxidases.
Proc Natl Acad Sci U S A
; 118(40)2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34580201
5.
Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering.
Angew Chem Int Ed Engl
; 62(35): e202303879, 2023 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37260412
6.
Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted Cyclopropanes by Carbene Transfer.
Angew Chem Int Ed Engl
; 62(4): e202208936, 2023 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36533936
7.
Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of Enantioselectivity.
J Am Chem Soc
; 144(29): 13344-13355, 2022 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35830682
8.
Enzymatic Control over Reactive Intermediates Enables Direct Oxidation of Alkenes to Carbonyls by a P450 Iron-Oxo Species.
J Am Chem Soc
; 144(35): 15954-15968, 2022 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35998887
9.
An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes.
J Am Chem Soc
; 144(1): 80-85, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34941252
10.
Enabling microbial syringol conversion through structure-guided protein engineering.
Proc Natl Acad Sci U S A
; 116(28): 13970-13976, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235604
11.
Selective Biocatalytic N-Methylation of Unsaturated Heterocycles.
Angew Chem Int Ed Engl
; 61(48): e202213056, 2022 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202763
12.
The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions.
J Am Chem Soc
; 143(37): 14939-14950, 2021 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34491742
13.
Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si-H and N-H bonds.
J Am Chem Soc
; 143(18): 7114-7123, 2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33909977
14.
Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation.
Chembiochem
; 22(5): 904-914, 2021 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33094545
15.
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase.
Proc Natl Acad Sci U S A
; 115(28): 7308-7313, 2018 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29946033
16.
Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.
J Biol Chem
; 294(44): 15947-15961, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488542
17.
Regioselective Synthesis and Characterization of Tris- and Tetra-Prato Adducts of M3N@C80 (M = Y, Gd).
J Am Chem Soc
; 142(30): 12954-12965, 2020 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32586092
18.
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.
Nat Chem Biol
; 14(4): 345-351, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29531360
19.
Selective Enzymatic Oxidation of Silanes to Silanols.
Angew Chem Int Ed Engl
; 59(36): 15507-15511, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32212229
20.
Regio- and Stereoselective Steroid Hydroxylation at C7 by Cytochromeâ P450 Monooxygenase Mutants.
Angew Chem Int Ed Engl
; 59(30): 12499-12505, 2020 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32243054