Detalhe da pesquisa
1.
Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators.
Bioorg Med Chem
; 26(12): 3227-3241, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29735425
2.
Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite.
Bioorg Med Chem Lett
; 25(5): 1135-9, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575656
3.
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Bioorg Med Chem Lett
; 25(5): 1140-5, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599836
4.
A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS).
Bioorg Med Chem Lett
; 25(2): 210-5, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25515558
5.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
6.
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.
Antimicrob Agents Chemother
; 57(7): 3358-68, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23650168
7.
Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions.
Pharm Res
; 30(4): 996-1007, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23269503
8.
Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.
Bioorg Med Chem Lett
; 23(15): 4447-52, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773863
9.
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Bioorg Med Chem Lett
; 23(24): 6879-85, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24176401
10.
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.
Bioorg Med Chem Lett
; 23(11): 3401-5, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23601710
11.
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett
; 23(13): 3967-75, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23673016
12.
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Bioorg Med Chem Lett
; 23(13): 3841-7, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726345
13.
Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.
Bioorg Med Chem Lett
; 23(14): 4267-71, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735741
14.
Assessment of CYP3A-mediated drug-drug interaction potential for victim drugs using an in vivo rat model.
Biopharm Drug Dispos
; 34(7): 396-401, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23873286
15.
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
Antimicrob Agents Chemother
; 56(10): 5381-6, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22869578
16.
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Bioorg Med Chem Lett
; 22(24): 7512-7, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23122820
17.
Cross-species absorption, metabolism, distribution and pharmacokinetics of BI 201335, a potent HCV genotype 1 NS3/4A protease inhibitor.
Xenobiotica
; 42(2): 164-72, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21988548
18.
Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy.
Transl Vis Sci Technol
; 11(6): 17, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35727188
19.
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons.
Bioorg Med Chem Lett
; 21(12): 3658-63, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21550240
20.
Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.
Bioorg Med Chem Lett
; 21(12): 3664-70, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21592789