Detalhe da pesquisa
1.
Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches.
Bioorg Med Chem Lett
; 25(3): 575-80, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556098
2.
Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.
Bioorg Med Chem Lett
; 25(3): 581-6, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25556092
3.
Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
Bioorg Med Chem Lett
; 25(3): 587-92, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575658
4.
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
Bioorg Med Chem Lett
; 21(14): 4276-80, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689933
5.
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.
Bioorg Med Chem Lett
; 21(7): 2011-6, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21354795
6.
Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.
Bioorg Med Chem
; 19(19): 5833-51, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903398
7.
Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers.
Sci Rep
; 11(1): 19877, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34615939
8.
Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 20(17): 5165-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20667729
9.
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
Bioorg Med Chem Lett
; 20(16): 4901-5, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638279
10.
Morpholine containing CB2 selective agonists.
Bioorg Med Chem Lett
; 19(6): 1604-9, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19243942
11.
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Bioorg Med Chem Lett
; 18(5): 1725-9, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18255291
12.
A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR development.
J Biomol Screen
; 18(8): 868-78, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796689
13.
Using electrophysiology and in silico three-dimensional modeling to reduce human Ether-à-go-go related gene K(+) channel inhibition in a histamine H3 receptor antagonist program.
Assay Drug Dev Technol
; 8(6): 781-9, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21133680
14.
The histamine H3 receptor as a therapeutic drug target for CNS disorders.
Drug Discov Today
; 14(9-10): 509-15, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19429511