Detalhe da pesquisa
1.
Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Drug Metab Dispos
; 52(6): 539-547, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38604730
2.
Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Drug Metab Dispos
; 52(3): 153-158, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216306
3.
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective.
Xenobiotica
; 53(8-9): 547-558, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37880944
4.
Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance.
Drug Metab Dispos
; 50(4): 320-326, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115299
5.
Increasing the Reuse of Protein Non-Naïve Nonhuman Primates in Pharmaceutical Drug Discovery and Development: An Overview and Industry Position on the Challenges and Benefits.
Int J Toxicol
; 41(4): 291-296, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35656559
6.
Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Drug Metab Dispos
; 49(8): 668-678, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34035124
7.
Crystalline Sponges as a Sensitive and Fast Method for Metabolite Identification: Application to Gemfibrozil and its Phase I and II Metabolites.
Drug Metab Dispos
; 48(7): 587-593, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32434832
8.
Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Clin Pharmacol Ther
; 115(5): 931-938, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38018358
9.
Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Clin Pharmacol Ther
; 113(4): 775-781, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35733280
10.
Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds.
AAPS J
; 24(2): 41, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35277751
11.
Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.
Proc Natl Acad Sci U S A
; 105(48): 18901-6, 2008 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19028872
12.
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis.
Eur J Pharm Sci
; 164: 105884, 2021 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161782
13.
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
ChemMedChem
; 16(24): 3653-3662, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582626
14.
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem
; 64(19): 14603-14619, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34596404
15.
Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry.
Anal Chem
; 81(19): 8085-93, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19715299
16.
Changes in PTGS1 and ALOX12 Gene Expression in Peripheral Blood Mononuclear Cells Are Associated with Changes in Arachidonic Acid, Oxylipins, and Oxylipin/Fatty Acid Ratios in Response to Omega-3 Fatty Acid Supplementation.
PLoS One
; 10(12): e0144996, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26672987
17.
Pharmacophore-based design of novel oxadiazoles as selective sphingosine-1-phosphate (S1P) receptor agonists with in vivo efficacy.
ChemMedChem
; 10(4): 688-714, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25735812
18.
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
J Med Chem
; 58(4): 1717-35, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25680029
19.
Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
ACS Med Chem Lett
; 4(11): 1037-41, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900603
20.
Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids.
PLoS One
; 8(10): e76575, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24204640