Minimalistic toy robot to analyze a scenery of speaker-listener condition in autism.

Atypical neural architecture causes impairment in communication capabilities and reduces the ability of representing the referential statements of other people in children with autism. During a scenery of "speaker-listener" communication, we have analyzed verbal and emotional expressions in neurotypical children (n = 20) and in children with autism (n = 20). The speaker was always a child, and the listener was a human or a minimalistic robot which reacts to speech expression by nodding only. Although both groups performed the task, everything happens as if the robot could allow children with autism to elaborate a multivariate equation encoding and conceptualizing within his/her brain, and externalizing into unconscious emotion (heart rate) and conscious verbal speech (words). Such a behavior would indicate that minimalistic artificial environments such as toy robots could be considered as the root of neuronal organization and reorganization with the potential to improve brain activity.

Predicting neural activity of whole body cast shadow through object cast shadow in dynamic environments.

Shadows, as all other objects that surround us, are incorporated into the body and extend the body mediating perceptual information. The current study investigates the hypothesis according to which the perception of object shadows would predict the perception of body shadows. 38 participants (19 males and 19 females) aged 23 years on average were immersed into a virtual reality environment and instructed to perceive and indicate the coincidence or non coincidence between the movement of a ball shadow with regard to ball movement on the one hand, and between their body shadow and their body position in space on the other. Their brain activity was recording via a 32-channel EEG system, in which beta (13.5-30 Hz) oscillations were analyzed. A series of Multiple Regression Analysis (MRA) revealed that the beta dynamic oscillations patterns of the bilateral occipito-parieto-frontal pathway associated with the perception of ball shadow appeared to be a significant predictor of the increase in beta oscillations across frontal areas related to the body shadow perception and the decrease in beta oscillations across frontal areas connected to the decision making of the body shadow. Taken together, the findings suggest that inferential thinking ability relative to body shadow would be reliably predicted from object shadows and that the bilateral beta oscillatory modulations would be indicative of the formation of predictive neural frontal assemblies, which encode and infer body shadow neural representation, that is, a substitution of the physical body.

Multimodal interactions in typically and atypically developing children: natural versus artificial environments.

This review addresses the central role played by multimodal interactions in neurocognitive development. We first analyzed our studies of multimodal verbal and nonverbal cognition and emotional interactions within neuronal, that is, natural environments in typically developing children. We then tried to relate them to the topic of creating artificial environments using mobile toy robots to neurorehabilitate severely autistic children. By doing so, both neural/natural and artificial environments are considered as the basis of neuronal organization and reorganization. The common thread underlying the thinking behind this approach revolves around the brain's intrinsic properties: neuroplasticity and the fact that the brain is neurodynamic. In our approach, neural organization and reorganization using natural or artificial environments aspires to bring computational perspectives into cognitive developmental neuroscience.

The role of ventral tegmental area in chronic stroke rehabilitation: an exploratory study.

Introduction: The acknowledged role of external rewards in chronic stroke rehabilitation, offering positive reinforcement and motivation, has significantly contributed to patient engagement and perseverance. However, the exploration of self-reward's importance in this context remains limited. This study aims to investigate the functional connectivity of the ventral tegmental area (VTA), a key node in the brain's reward circuitry, during motor task-based rehabilitation and its correlation with the recovery process. Methods: Twelve right-handed healthy volunteers (4 men, 8 women, aged 57.4 ± 11.3 years) and twelve chronic stroke patients (5 men, 7 women, aged 48.1 ± 11.1 years) with clinically significant right-sided motor impairment (mean FM-UE score of 27.6 ± 8.7) participated. The analysis employed the CONN toolbox to assess the association between motor tasks and VTA connectivity using psychophysiological interaction (PPI). Results: PPI analysis revealed motor-dependent changes in VTA connectivity, particularly with regions within the motor circuitry, cerebellum, and prefrontal cortex. Notably, stronger connectivity between the ipsilesional VTA and cerebellum was observed in healthy controls compared to chronic stroke patients, highlighting the importance of VTA-cerebellum interactions in motor function. Stroke patients' motor performance was associated with VTA modulation in areas related to both motor tasks and reward processing, emphasizing the role of self-reward processes in rehabilitation. Changes in VTA influence on motor circuitry were linked to improvements in motor performance resulting from rehabilitation. Discussion: Our findings underscore the potential of neuroimaging techniques in quantifying and predicting rehabilitation outcomes by examining self-reward processes. The observed associations between VTA connectivity and motor performance in both healthy and stroke-affected individuals emphasize the role of psychological factors, particularly self-reward, in the rehabilitation process. This study contributes valuable insights into the intricate interplay between reward circuits and motor function, highlighting the importance of addressing psychological dimensions in neurorehabilitation strategies.

Neural Kinesthetic Contribution to Motor Imagery of Body Parts: Tongue, Hands, and Feet.

Motor imagery (MI) is assimilated to a perception-action process, which is mentally represented. Although several models suggest that MI, and its equivalent motor execution, engage very similar brain areas, the mechanisms underlying MI and their associated components are still under investigation today. Using 22 Ag/AgCl EEG electrodes, 19 healthy participants (nine males and 10 females) with an average age of 25.8 years old (sd = 3.5 years) were required to imagine moving several parts of their body (i.e., first-person perspective) one by one: left and right hand, tongue, and feet. Network connectivity analysis based on graph theory, together with a correlational analysis, were performed on the data. The findings suggest evidence for motor and somesthetic neural synchronization and underline the role of the parietofrontal network for the tongue imagery task only. At both unilateral and bilateral cortical levels, only the tongue imagery task appears to be associated with motor and somatosensory representations, that is, kinesthetic representations, which might contribute to verbal actions. As such, the present findings suggest the idea that imagined tongue movements, involving segmentary kinesthetic actions, could be the prerequisite of language.

Ordered interpersonal synchronisation in ASD children via robots.

Children with autistic spectrum disorders (ASD) experience persistent disrupted coordination in interpersonal synchronisation that is thought to be associated with deficits in neural connectivity. Robotic interventions have been explored for use with ASD children worldwide revealing that robots encourage one-to-one social and emotional interactions. However, associations between interpersonal synchronisation and emotional empathy have not yet been directly explored in French and Japanese ASD children when they interact with a human or a robot under analogous experimental conditions. Using the paradigm of actor-perceiver, where the child was the actor and the robot or the human the perceiver, we recorded the autonomic heart rate activation and reported emotional feelings of ASD children in both countries. Japanese and French ASD children showed different interpersonal synchronisation when they interacted with the human perceiver, even though the human was the same in both countries. However, they exhibited similar interpersonal synchronisation when the perceiver was the robot. The findings suggest that the mechanism combining interpersonal synchronisation and emotional empathy might be weakened but not absent in ASD children and that both French and Japanese ASD children do spontaneously and unconsciously discern non verbal actions of non human partners through a direct matching process that occurs via automatic mapping.

Emotional Empathy as a Mechanism of Synchronisation in Child-Robot Interaction.

Simulating emotional experience, emotional empathy is the fundamental ingredient of interpersonal communication. In the speaker-listener scenario, the speaker is always a child, the listener is a human or a toy robot. Two groups of neurotypical children aged 6 years on average composed the population: one Japanese (n = 20) and one French (n = 20). Revealing potential similarities in communicative exchanges in both groups when in contact with a human or a toy robot, the results might signify that emotional empathy requires the implication of an automatic identification. In this sense, emotional empathy might be considered a broad idiosyncrasy, a kind of synchronisation, offering the mind a peculiar form of communication. Our findings seem to be consistent with the assumption that children's brains would be constructed to simulate the feelings of others in order to ensure interpersonal synchronisation.

Time perception in patients with dementia with Lewy bodies.

Disturbances of time perception could explain some behavioral disorders in patients with dementia with Lewy bodies (DLB), and the aim of this preliminary study was to evaluate time perception in these patients. 7 patients with DLB (mean age = 82±6,8 years) were compared to 7 cognitively normal subjects (m = 81.2±6,8 years) for spatiotemporal orientation, verbal estimation, semantic knowledge, rhythm perception and verbal time estimation. The scores on the semantic scale of temporality were statistically different between the two groups, and patients made more rhythm errors than the control sample. Moreover, a significant improvement between the first and second assessment on verbal time estimation was found in the control subjetcs but not in the patients. Time perception seems to be disturbed in patients with DLB, but more studies are required to understand this result with the behavioural disorders.

Multimodal interactions in free game play of children with autism and a mobile toy robot.

Autism is a complex neuropsychological disorder characterized by qualitative alterations in social interaction and interpersonal communication. The aim of this study is to estimate the interaction between autistic children and a mobile toy robot during free spontaneous game play. The duration of different criteria including eye contact, touch, manipulation, and posture have been considered. The variety of interactions of children with autism and the mobile toy robot show that the children take an interest in playing with the robot. This study suggests that the mobile toy robot in an ecological situation such as free, spontaneous game play could be used as a mediator of social stimuli in order to reduce the impairment of autistic children skills related to social information understanding and interaction.