Detalhe da pesquisa
1.
Ibrexafungerp: An orally active ß-1,3-glucan synthesis inhibitor.
Bioorg Med Chem Lett
; 32: 127661, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33160023
2.
Selective small-molecule inhibition of an RNA structural element.
Nature
; 526(7575): 672-7, 2015 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416753
3.
MK-5204: An orally active ß-1,3-glucan synthesis inhibitor.
Bioorg Med Chem Lett
; 30(17): 127357, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738971
4.
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373794
5.
Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.
PLoS Pathog
; 12(5): e1005585, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144276
6.
Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.
Anal Biochem
; 518: 9-15, 2017 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815077
7.
In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.
Antimicrob Agents Chemother
; 60(8): 4830-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27246784
8.
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
J Pharmacol Exp Ther
; 359(1): 194-206, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432892
9.
Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Bioorg Med Chem Lett
; 25(12): 2473-8, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978963
10.
Novel orally active inhibitors of ß-1,3-glucan synthesis derived from enfumafungin.
Bioorg Med Chem Lett
; 25(24): 5813-8, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542966
11.
Platensimycin is a selective FabF inhibitor with potent antibiotic properties.
Nature
; 441(7091): 358-61, 2006 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16710421
12.
Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis.
Antimicrob Agents Chemother
; 55(7): 3491-7, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21518846
13.
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.
Chem Biol
; 15(4): 363-74, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18420143
14.
Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347.
J Am Chem Soc
; 130(36): 12102-10, 2008 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18698773
15.
Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
J Antibiot (Tokyo)
; 60(9): 565-71, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17917239
16.
Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.
Cell Chem Biol
; 24(5): 576-588.e6, 2017 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434876
17.
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
J Med Chem
; 60(9): 3851-3865, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322556
18.
TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Sci Transl Med
; 8(329): 329ra32, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26962156
19.
Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.
Chem Biol
; 22(10): 1362-73, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26456734
20.
Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin.
J Antibiot (Tokyo)
; 67(7): 527-31, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24690911