Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing.

Leighton, Gage O; Shang, Shengzhe; Hageman, Sean; Ginder, Gordon D; Williams, David C.

Proc Natl Acad Sci U S A ; 120(33): e2307287120, 2023 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-37552759

2.

MBD2a-NuRD binds to the methylated Î³-globin gene promoter and uniquely forms a complex required for silencing of HbF expression.

Shang, Shengzhe; Li, Xia; Azzo, Alexander; Truong, Tin; Dozmorov, Mikhail; Lyons, Charles; Manna, Asit K; Williams, David C; Ginder, Gordon D.

Proc Natl Acad Sci U S A ; 120(25): e2302254120, 2023 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-37307480

3.

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells.

Yu, Xiaofei; Azzo, Alexander; Bilinovich, Stephanie M; Li, Xia; Dozmorov, Mikhail; Kurita, Ryo; Nakamura, Yukio; Williams, David C; Ginder, Gordon D.

Haematologica ; 104(12): 2361-2371, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31004025

4.

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation.

Sperlazza, Justin; Rahmani, Mohamed; Beckta, Jason; Aust, Mandy; Hawkins, Elisa; Wang, Shou Zhen; Zu Zhu, Sheng; Podder, Shreya; Dumur, Catherine; Archer, Kellie; Grant, Steven; Ginder, Gordon D.

Blood ; 126(12): 1462-72, 2015 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-26265695

5.

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.

Desai, Megha A; Webb, Heather D; Sinanan, Leander M; Scarsdale, J Neel; Walavalkar, Ninad M; Ginder, Gordon D; Williams, David C.

Nucleic Acids Res ; 43(6): 3100-13, 2015 Mar 31.

Artigo em Inglês | MEDLINE | ID: mdl-25753662

6.

Probing the dynamic distribution of bound states for methylcytosine-binding domains on DNA.

Cramer, Jason M; Scarsdale, J Neel; Walavalkar, Ninad M; Buchwald, William A; Ginder, Gordon D; Williams, David C.

J Biol Chem ; 289(3): 1294-302, 2014 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-24307175

7.

Mi2ß-mediated silencing of the fetal Î³-globin gene in adult erythroid cells.

Amaya, Maria; Desai, Megha; Gnanapragasam, Merlin Nithya; Wang, Shou Zhen; Zu Zhu, Sheng; Williams, David C; Ginder, Gordon D.

Blood ; 121(17): 3493-501, 2013 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-23444401

8.

p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.

Gnanapragasam, Merlin Nithya; Scarsdale, J Neel; Amaya, Maria L; Webb, Heather D; Desai, Megha A; Walavalkar, Ninad M; Wang, Shou Zhen; Zu Zhu, Sheng; Ginder, Gordon D; Williams, David C.

Proc Natl Acad Sci U S A ; 108(18): 7487-92, 2011 May 03.

Artigo em Inglês | MEDLINE | ID: mdl-21490301

9.

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.

Scarsdale, J Neel; Webb, Heather D; Ginder, Gordon D; Williams, David C.

Nucleic Acids Res ; 39(15): 6741-52, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21531701

10.

Acute myeloid leukemia: how the uninsured fare.

Bradley, Cathy J; Dahman, Bassam; Jin, Yan; Shickle, Lisa M; Ginder, Gordon D.

Cancer ; 117(20): 4772-8, 2011 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-21455994

11.

MBD2 contributes to developmental silencing of the human Îµ-globin gene.

Rupon, Jeremy W; Wang, Shou Zhen; Gnanapragasam, Merlin; Labropoulos, Stefanos; Ginder, Gordon D.

Blood Cells Mol Dis ; 46(3): 212-9, 2011 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-21296012

12.

EV(I1)olution of AML DNA methylation.

Ginder, Gordon D.

Blood ; 117(1): 4-5, 2011 Jan 06.

Artigo em Inglês | MEDLINE | ID: mdl-21212288

13.

Readers of DNA methylation, the MBD family as potential therapeutic targets.

Ginder, Gordon D; Williams, David C.

Pharmacol Ther ; 184: 98-111, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29128342

14.

In Vitro Erythroid Differentiation and Lentiviral Knockdown in Human CD34+ Cells from Umbilical Cord Blood.

Kovilakath, Anna; Mohamad, Safa; Hermes, Farrah; Wang, Shou Zhen; Ginder, Gordon D; Lloyd, Joyce A.

Methods Mol Biol ; 1698: 259-274, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29076096

15.

A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon.

Barrett, David M; Gustafson, Karen S; Wang, Jing; Wang, Shou Zhen; Ginder, Gordon D.

Mol Cell Biol ; 24(14): 6194-204, 2004 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15226423

16.

Epigenetic regulation of fetal globin gene expression in adult erythroid cells.

Ginder, Gordon D.

Transl Res ; 165(1): 115-25, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24880147

17.

Corrigendum to "Readers of DNA methylation, the MBD family as potential therapeutic targets" [Pharmacology & Therapeutics 184 (1) (2018) 98-111].

Ginder, Gordon D; Williams, David C.

Pharmacol Ther ; 190: 237-238, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30268235

18.

Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.

Mian, Omar Y; Wang, Shou Zhen; Zhu, Sheng Zu; Gnanapragasam, Merlin N; Graham, Laura; Bear, Harry D; Ginder, Gordon D.

Mol Cancer Res ; 9(8): 1152-62, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21693597

19.

The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development.

Ginder, Gordon D; Gnanapragasam, Merlin N; Mian, Omar Y.

Curr Top Dev Biol ; 82: 85-116, 2008.

Artigo em Inglês | MEDLINE | ID: mdl-18282518

20.

Differential IFN-gamma stimulation of HLA-A gene expression through CRM-1-dependent nuclear RNA export.

Browne, Sarah K; Roesser, James R; Zhu, Sheng Zu; Ginder, Gordon D.

J Immunol ; 177(12): 8612-9, 2006 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-17142760

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