Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine.

Li, Chunfeng; Lee, Audrey; Grigoryan, Lilit; Arunachalam, Prabhu S; Scott, Madeleine K D; Trisal, Meera; Wimmers, Florian; Sanyal, Mrinmoy; Weidenbacher, Payton A; Feng, Yupeng; Adamska, Julia Z; Valore, Erika; Wang, Yanli; Verma, Rohit; Reis, Noah; Dunham, Diane; O'Hara, Ruth; Park, Helen; Luo, Wei; Gitlin, Alexander D; Kim, Peter; Khatri, Purvesh; Nadeau, Kari C; Pulendran, Bali.

Nat Immunol ; 23(4): 543-555, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35288714

2.

N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.

Gitlin, Alexander D; Maltzman, Allie; Kanno, Yuzuka; Heger, Klaus; Reja, Rohit; Schubert, Alexander F; Wierciszewski, Linsey J; Pantua, Homer; Kapadia, Sharookh B; Harris, Seth F; Webster, Joshua D; Newton, Kim; Dixit, Vishva M.

Immunity ; 57(5): 973-986.e7, 2024 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-38697117

3.

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.

Escolano, Amelia; Steichen, Jon M; Dosenovic, Pia; Kulp, Daniel W; Golijanin, Jovana; Sok, Devin; Freund, Natalia T; Gitlin, Alexander D; Oliveira, Thiago; Araki, Tatsuya; Lowe, Sarina; Chen, Spencer T; Heinemann, Jennifer; Yao, Kai-Hui; Georgeson, Erik; Saye-Francisco, Karen L; Gazumyan, Anna; Adachi, Yumiko; Kubitz, Michael; Burton, Dennis R; Schief, William R; Nussenzweig, Michel C.

Cell ; 166(6): 1445-1458.e12, 2016 Sep 08.

Artigo em Inglês | MEDLINE | ID: mdl-27610569

4.

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.

Dosenovic, Pia; von Boehmer, Lotta; Escolano, Amelia; Jardine, Joseph; Freund, Natalia T; Gitlin, Alexander D; McGuire, Andrew T; Kulp, Daniel W; Oliveira, Thiago; Scharf, Louise; Pietzsch, John; Gray, Matthew D; Cupo, Albert; van Gils, Marit J; Yao, Kai-Hui; Liu, Cassie; Gazumyan, Anna; Seaman, Michael S; Björkman, Pamela J; Sanders, Rogier W; Moore, John P; Stamatatos, Leonidas; Schief, William R; Nussenzweig, Michel C.

Cell ; 161(7): 1505-15, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26091035

5.

Integration of innate immune signalling by caspase-8 cleavage of N4BP1.

Gitlin, Alexander D; Heger, Klaus; Schubert, Alexander F; Reja, Rohit; Yan, Donghong; Pham, Victoria C; Suto, Eric; Zhang, Juan; Kwon, Youngsu C; Freund, Emily C; Kang, Jing; Pham, Anna; Caothien, Roger; Bacarro, Natasha; Hinkle, Trent; Xu, Min; McKenzie, Brent S; Haley, Benjamin; Lee, Wyne P; Lill, Jennie R; Roose-Girma, Merone; Dohse, Monika; Webster, Joshua D; Newton, Kim; Dixit, Vishva M.

Nature ; 587(7833): 275-280, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32971525

6.

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory.

Gitlin, Alexander D; von Boehmer, Lotta; Gazumyan, Anna; Shulman, Ziv; Oliveira, Thiago Y; Nussenzweig, Michel C.

Immunity ; 44(4): 769-81, 2016 Apr 19.

Artigo em Inglês | MEDLINE | ID: mdl-26944202

7.

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.

Steichen, Jon M; Kulp, Daniel W; Tokatlian, Talar; Escolano, Amelia; Dosenovic, Pia; Stanfield, Robyn L; McCoy, Laura E; Ozorowski, Gabriel; Hu, Xiaozhen; Kalyuzhniy, Oleksandr; Briney, Bryan; Schiffner, Torben; Garces, Fernando; Freund, Natalia T; Gitlin, Alexander D; Menis, Sergey; Georgeson, Erik; Kubitz, Michael; Adachi, Yumiko; Jones, Meaghan; Mutafyan, Andrew A; Yun, Dong Soo; Mayer, Christian T; Ward, Andrew B; Burton, Dennis R; Wilson, Ian A; Irvine, Darrell J; Nussenzweig, Michel C; Schief, William R.

Immunity ; 45(3): 483-496, 2016 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-27617678

8.

Deubiquitinases in cell death and inflammation.

Newton, Kim; Gitlin, Alexander D.

Biochem J ; 479(10): 1103-1119, 2022 05 27.

Artigo em Inglês | MEDLINE | ID: mdl-35608338

9.

Clonal selection in the germinal centre by regulated proliferation and hypermutation.

Gitlin, Alexander D; Shulman, Ziv; Nussenzweig, Michel C.

Nature ; 509(7502): 637-40, 2014 May 29.

Artigo em Inglês | MEDLINE | ID: mdl-24805232

10.

Immunology: Fifty years of B lymphocytes.

Gitlin, Alexander D; Nussenzweig, Michel C.

Nature ; 517(7533): 139-41, 2015 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-25567266

11.

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.

Horwitz, Joshua A; Halper-Stromberg, Ariel; Mouquet, Hugo; Gitlin, Alexander D; Tretiakova, Anna; Eisenreich, Thomas R; Malbec, Marine; Gravemann, Sophia; Billerbeck, Eva; Dorner, Marcus; Büning, Hildegard; Schwartz, Olivier; Knops, Elena; Kaiser, Rolf; Seaman, Michael S; Wilson, James M; Rice, Charles M; Ploss, Alexander; Bjorkman, Pamela J; Klein, Florian; Nussenzweig, Michel C.

Proc Natl Acad Sci U S A ; 110(41): 16538-43, 2013 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-24043801

12.

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

Kubicek, Stefan; Gilbert, Joshua C; Fomina-Yadlin, Dina; Gitlin, Alexander D; Yuan, Yuan; Wagner, Florence F; Holson, Edward B; Luo, Tuoping; Lewis, Timothy A; Taylor, Bradley; Gupta, Supriya; Shamji, Alykhan F; Wagner, Bridget K; Clemons, Paul A; Schreiber, Stuart L.

Proc Natl Acad Sci U S A ; 109(14): 5364-9, 2012 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-22434908

13.

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.

Kim, Eui Ho; Woodruff, Matthew C; Grigoryan, Lilit; Maier, Barbara; Lee, Song Hee; Mandal, Pratyusha; Cortese, Mario; Natrajan, Muktha S; Ravindran, Rajesh; Ma, Huailiang; Merad, Miriam; Gitlin, Alexander D; Mocarski, Edward S; Jacob, Joshy; Pulendran, Bali.

Elife ; 92020 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-32515732

14.

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.

Zaretsky, Irina; Atrakchi, Ofir; Mazor, Roei D; Stoler-Barak, Liat; Biram, Adi; Feigelson, Sara W; Gitlin, Alexander D; Engelhardt, Britta; Shulman, Ziv.

J Exp Med ; 214(11): 3435-3448, 2017 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-28939548

15.

The microanatomic segregation of selection by apoptosis in the germinal center.

Mayer, Christian T; Gazumyan, Anna; Kara, Ervin E; Gitlin, Alexander D; Golijanin, Jovana; Viant, Charlotte; Pai, Joy; Oliveira, Thiago Y; Wang, Qiao; Escolano, Amelia; Medina-Ramirez, Max; Sanders, Rogier W; Nussenzweig, Michel C.

Science ; 358(6360)2017 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-28935768

16.

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Medina-Ramírez, Max; Garces, Fernando; Escolano, Amelia; Skog, Patrick; de Taeye, Steven W; Del Moral-Sanchez, Ivan; McGuire, Andrew T; Yasmeen, Anila; Behrens, Anna-Janina; Ozorowski, Gabriel; van den Kerkhof, Tom L G M; Freund, Natalia T; Dosenovic, Pia; Hua, Yuanzi; Gitlin, Alexander D; Cupo, Albert; van der Woude, Patricia; Golabek, Michael; Sliepen, Kwinten; Blane, Tanya; Kootstra, Neeltje; van Breemen, Mariëlle J; Pritchard, Laura K; Stanfield, Robyn L; Crispin, Max; Ward, Andrew B; Stamatatos, Leonidas; Klasse, Per Johan; Moore, John P; Nemazee, David; Nussenzweig, Michel C; Wilson, Ian A; Sanders, Rogier W.

J Exp Med ; 214(9): 2573-2590, 2017 Sep 04.

Artigo em Inglês | MEDLINE | ID: mdl-28847869

17.

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.

von Boehmer, Lotta; Liu, Cassie; Ackerman, Sarah; Gitlin, Alexander D; Wang, Qiao; Gazumyan, Anna; Nussenzweig, Michel C.

Nat Protoc ; 11(10): 1908-1923, 2016 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-27658009

18.

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

McGuire, Andrew T; Gray, Matthew D; Dosenovic, Pia; Gitlin, Alexander D; Freund, Natalia T; Petersen, John; Correnti, Colin; Johnsen, William; Kegel, Robert; Stuart, Andrew B; Glenn, Jolene; Seaman, Michael S; Schief, William R; Strong, Roland K; Nussenzweig, Michel C; Stamatatos, Leonidas.

Nat Commun ; 7: 10618, 2016 Feb 24.

Artigo em Inglês | MEDLINE | ID: mdl-26907590

19.

HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.

Gitlin, Alexander D; Mayer, Christian T; Oliveira, Thiago Y; Shulman, Ziv; Jones, Mathew J K; Koren, Amnon; Nussenzweig, Michel C.

Science ; 349(6248): 643-6, 2015 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-26184917

20.

Dynamic signaling by T follicular helper cells during germinal center B cell selection.

Shulman, Ziv; Gitlin, Alexander D; Weinstein, Jason S; Lainez, Begoña; Esplugues, Enric; Flavell, Richard A; Craft, Joseph E; Nussenzweig, Michel C.

Science ; 345(6200): 1058-62, 2014 Aug 29.

Artigo em Inglês | MEDLINE | ID: mdl-25170154

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