Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 181(6): 1291-1306.e19, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32407674

2.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Beumer, Joep; Puschhof, Jens; Bauzá-Martinez, Julia; Martínez-Silgado, Adriana; Elmentaite, Rasa; James, Kylie R; Ross, Alexander; Hendriks, Delilah; Artegiani, Benedetta; Busslinger, Georg A; Ponsioen, Bas; Andersson-Rolf, Amanda; Saftien, Aurelia; Boot, Charelle; Kretzschmar, Kai; Geurts, Maarten H; Bar-Ephraim, Yotam E; Pleguezuelos-Manzano, Cayetano; Post, Yorick; Begthel, Harry; van der Linden, Franka; Lopez-Iglesias, Carmen; van de Wetering, Willine J; van der Linden, Reinier; Peters, Peter J; Heck, Albert J R; Goedhart, Joachim; Snippert, Hugo; Zilbauer, Matthias; Teichmann, Sarah A; Wu, Wei; Clevers, Hans.

Cell ; 182(4): 1062-1064, 2020 Aug 20.

Artigo em Inglês | MEDLINE | ID: mdl-32822568

3.

Cell-based optimization and characterization of genetically encoded location-based biosensors for Cdc42 or Rac activity.

Mahlandt, Eike K; Kreider-Letterman, Gabriel; Chertkova, Anna O; Garcia-Mata, Rafael; Goedhart, Joachim.

J Cell Sci ; 136(10)2023 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-37226883

4.

Studentsourcing-Aggregating and reusing data from a practical cell biology course.

Goedhart, Joachim.

PLoS Comput Biol ; 20(2): e1011836, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38358960

5.

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1.

Grönloh, Max L B; Arts, Janine J G; Palacios Martínez, Sebastián; van der Veen, Amerens A; Kempers, Lanette; van Steen, Abraham C I; Roelofs, Joris J T H; Nolte, Martijn A; Goedhart, Joachim; van Buul, Jaap D.

EMBO Rep ; 24(1): e55483, 2023 01 09.

Artigo em Inglês | MEDLINE | ID: mdl-36382783

6.

Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors.

Chavez-Abiega, Sergei; Grönloh, Max L B; Gadella, Theodorus W J; Bruggeman, Frank J; Goedhart, Joachim.

J Cell Sci ; 135(6)2022 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-35107584

7.

HI-NESS: a family of genetically encoded DNA labels based on a bacterial nucleoid-associated protein.

Rashid, Fatema-Zahra M; Mahlandt, Eike; van der Vaart, Michiel; Boer, Daphne E C; Varela Alvarez, Monica; Henneman, Bram; Brocken, Daan J W; Voskamp, Patrick; Blok, Anneloes J; Shimizu, Thomas S; Meijer, Annemarie H; Luijsterburg, Martijn S; Goedhart, Joachim; Crémazy, Frédéric G E; Dame, Remus T.

Nucleic Acids Res ; 50(2): e10, 2022 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-34734265

8.

Visualizing endogenous Rho activity with an improved localization-based, genetically encoded biosensor.

Mahlandt, Eike K; Arts, Janine J G; van der Meer, Werner J; van der Linden, Franka H; Tol, Simon; van Buul, Jaap D; Gadella, Theodorus W J; Goedhart, Joachim.

J Cell Sci ; 134(17)2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-34357388

9.

PlotTwist: A web app for plotting and annotating continuous data.

Goedhart, Joachim.

PLoS Biol ; 18(1): e3000581, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31929523

10.

In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots.

Long, Yuchen; Stahl, Yvonne; Weidtkamp-Peters, Stefanie; Postma, Marten; Zhou, Wenkun; Goedhart, Joachim; Sánchez-Pérez, María-Isabel; Gadella, Theodorus W J; Simon, Rüdiger; Scheres, Ben; Blilou, Ikram.

Nature ; 548(7665): 97-102, 2017 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-28746306

11.

Breaking up the StayGold dimer yields three photostable monomers.

Goedhart, Joachim; Gadella, Theodorus W J.

Nat Methods ; 21(4): 558-559, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38485740

12.

PlotsOfData-A web app for visualizing data together with their summaries.

Postma, Marten; Goedhart, Joachim.

PLoS Biol ; 17(3): e3000202, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30917112

13.

Superfolder mTurquoise2^ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets.

Meiresonne, Nils Y; Consoli, Elisa; Mertens, Laureen M Y; Chertkova, Anna O; Goedhart, Joachim; den Blaauwen, Tanneke.

Mol Microbiol ; 111(4): 1025-1038, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30648295

14.

Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).

Chavez-Abiega, Sergei; Mos, Iris; Centeno, Patricia P; Elajnaf, Taha; Schlattl, Wolfgang; Ward, Donald T; Goedhart, Joachim; Kallay, Enikö.

Adv Exp Med Biol ; 1131: 1031-1063, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31646544

15.

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

Raspe, Marcel; Kedziora, Katarzyna M; van den Broek, Bram; Zhao, Qiaole; de Jong, Sander; Herz, Johan; Mastop, Marieke; Goedhart, Joachim; Gadella, Theodorus W J; Young, Ian T; Jalink, Kees.

Nat Methods ; 13(6): 501-4, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27088314

16.

Dispense with redundant P values.

Goedhart, Joachim.

Nature ; 554(7690): 31, 2018 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-32094848

17.

Dispense with redundant P values.

Goedhart, Joachim.

Nature ; 554(7690): 31, 2018 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-29388982

18.

Forward genetic screens identify a role for the mitochondrial HER2 in E-2-hexenal responsiveness.

Scala, Alessandra; Mirabella, Rossana; Goedhart, Joachim; de Vries, Michel; Haring, Michel A; Schuurink, Robert C.

Plant Mol Biol ; 95(4-5): 399-409, 2017 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-28918565

19.

In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes.

Vermeer, Joop E M; van Wijk, Ringo; Goedhart, Joachim; Geldner, Niko; Chory, Joanne; Gadella, Theodorus W J; Munnik, Teun.

Plant Cell Physiol ; 58(7): 1196-1207, 2017 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-28158855

20.

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.

Timmerman, Ilse; Heemskerk, Niels; Kroon, Jeffrey; Schaefer, Antje; van Rijssel, Jos; Hoogenboezem, Mark; van Unen, Jakobus; Goedhart, Joachim; Gadella, Theodorus W J; Yin, Taofei; Wu, Yi; Huveneers, Stephan; van Buul, Jaap D.

J Cell Sci ; 128(16): 3041-54, 2015 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-26116572

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High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells.

Cell-based optimization and characterization of genetically encoded location-based biosensors for Cdc42 or Rac activity.

Studentsourcing-Aggregating and reusing data from a practical cell biology course.

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1.

Single-cell imaging of ERK and Akt activation dynamics and heterogeneity induced by G-protein-coupled receptors.

HI-NESS: a family of genetically encoded DNA labels based on a bacterial nucleoid-associated protein.

Visualizing endogenous Rho activity with an improved localization-based, genetically encoded biosensor.

PlotTwist: A web app for plotting and annotating continuous data.

In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots.

Breaking up the StayGold dimer yields three photostable monomers.

PlotsOfData-A web app for visualizing data together with their summaries.

Superfolder mTurquoise2^ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets.

Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).

siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data.

Dispense with redundant P values.

Dispense with redundant P values.

Forward genetic screens identify a role for the mitochondrial HER2 in E-2-hexenal responsiveness.

In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes.

A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.