Detalhe da pesquisa
1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
2.
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 598(7881): 504-509, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34616043
3.
Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.
PLoS Comput Biol
; 19(12): e1011662, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38055683
4.
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 599(7883): E2, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671169
5.
Multiplexed multicolor antiviral assay amenable for high-throughput research.
Nat Commun
; 15(1): 42, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38168091
6.
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
J Med Chem
; 67(5): 4063-4082, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38482827
7.
A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships.
Antiviral Res
; 210: 105495, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36567021
8.
Therapeutics for flaviviral infections.
Antiviral Res
; 210: 105517, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36592668
9.
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.
J Med Chem
; 66(13): 8808-8821, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37389813
10.
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2'-Spirocyclic Uridines by Substituting Oxygen with Sulfur.
ACS Med Chem Lett
; 13(12): 1879-1884, 2022 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36518706
11.
Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors.
J Virol
; 82(21): 10366-74, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18715920
12.
Phylogenetically based establishment of a dengue virus panel, representing all available genotypes, as a tool in dengue drug discovery.
Antiviral Res
; 168: 109-113, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085207
13.
Binding kinetics, uptake and intracellular accumulation of F105, an anti-gp120 human IgG1kappa monoclonal antibody, in HIV-1 infected cells.
J Virol Methods
; 139(1): 17-23, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034868
14.
Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.
Antiviral Res
; 147: 149-158, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29037976
15.
Biochemical screening assays to identify HIV-1 integrase inhibitors.
Methods Mol Biol
; 1030: 25-36, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23821258
16.
Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor.
Antiviral Res
; 91(2): 167-76, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21669228
17.
Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles.
Virology
; 402(2): 338-46, 2010 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20421122
18.
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes.
Antiviral Res
; 84(2): 142-9, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19699239