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1.
J Surg Res ; 295: 296-301, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38056356

RESUMO

INTRODUCTION: Multiple studies have documented the safety of intestinal anastomosis after resection for necrotizing enterocolitis (NEC). We sought to evaluate a large population of infants with surgical NEC and assess outcomes after primary anastomosis versus enterostomy. METHODS: The Pediatric Health Information System database was used to identify infants with Bell Stage 3 NEC who underwent an intestinal resection for acute disease between 2016 and 2021. Demographics and preoperative physiology were assessed, and nutritional, infectious, and surgical outcomes were analyzed. RESULTS: Two hundred twenty-two infants at 38 children's hospitals were included. Thirty-five (15.8%) were managed with a primary anastomosis. Among infants who underwent a resection within 10 d of their first operative intervention and survived for at least 3 d, a primary anastomosis was used in 26 (13.7%). These patients were older but had similar weight and physiological status at the time of resection as those managed with an enterostomy. The incidence of wound and infectious complications, duration of parenteral nutrition and length of stay were similar after anastomosis or enterostomy. CONCLUSIONS: In a large, geographically heterogenous population of infants with NEC, only 15.8% were managed with a primary anastomosis after intestinal resection. Survivors who underwent resection within 10 d were demographically and physiologically comparable to those who underwent enterostomy and had similar surgical outcomes. While there are clearly indications for enterostomy in some infants with NEC, these data confirm the conclusions of smaller, single-center studies that a primary anastomosis should be considered more frequently.


Assuntos
Enterocolite Necrosante , Enterostomia , Doenças do Recém-Nascido , Lactente , Recém-Nascido , Humanos , Criança , Enterocolite Necrosante/epidemiologia , Enterocolite Necrosante/cirurgia , Intestinos/cirurgia , Enterostomia/efeitos adversos , Anastomose Cirúrgica/efeitos adversos , Doenças do Recém-Nascido/cirurgia , Hospitais , Estudos Retrospectivos
2.
J Surg Res ; 291: 265-269, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37480754

RESUMO

INTRODUCTION: Peritoneal drainage is an established management strategy for spontaneous intestinal perforation (SIP) in premature infants. We sought to evaluate the safety and efficacy of percutaneous pigtail catheter placement as an alternative to drain insertion via a lower quadrant incision. METHODS: Patients less than 32 weeks gestational age who underwent peritoneal drain placement for SIP at two neonatal intensive care units between 2011 and 2022 were identified. Incisional drainage (ID) or percutaneous pigtail catheter drainage (PD) was used based upon the usual practices of the surgeons. ID (n = 19) was performed via a 5-mm right lower quadrant incision into which a one-fourth-inch Penrose or red rubber catheter was placed. PD (n = 18) was accomplished using a Seldinger technique by which a 6.0 or 8.5 F pigtail catheter was passed through the left lower quadrant. Demographics and physiological parameters at the time of drainage were recorded and short-term and long-term outcomes were evaluated. RESULTS: Thirty seven infants were identified. There were no differences in demographics or physiological derangement between the groups. Patients who underwent ID had more frequent stool drainage, a greater transfusion requirement, and a longer time to full feedings (60.6 v 37.7 d, P = 0.04). Incisional hernias (n = 3, 16%) only developed after ID. The duration of drain placement, length of stay, and time to resolution of pneumoperitoneum were similar with ID and PD as was the incidence of premature drain dislodgement and subsequent laparotomy. CONCLUSIONS: Percutaneous drain placement provided effective drainage in infants with SIP and was associated with more rapid feeding advancement and no incidence of incisional hernia.


Assuntos
Hérnia Incisional , Perfuração Intestinal , Ferida Cirúrgica , Lactente , Recém-Nascido , Humanos , Perfuração Intestinal/etiologia , Perfuração Intestinal/cirurgia , Drenagem/efeitos adversos , Recém-Nascido Prematuro , Idade Gestacional , Catéteres
3.
J Surg Res ; 199(1): 67-71, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26227672

RESUMO

BACKGROUND: Long-term gastrojejunal (GJ) feeding is an increasingly popular alternative to gastric fundoplication for children with pathologic reflux, particularly those with neurologic impairment. We sought to evaluate morbidity associated with GJ feeding tubes in a large population of children. MATERIALS AND METHODS: The records of all children who underwent placement of a GJ feeding tube in a large children's hospital between January 2005 and September 2013 were reviewed. Indications for GJ feedings were noted. Events including a requirement for tube replacement and intestinal complications attributable to a GJ tube that required a laparotomy were evaluated. Risk factors for morbidity were assessed. RESULTS: A total of 124 children underwent GJ tube placement at an average age of 5.0 y (2 mo-16 y). Of the total, 83 (66%) subjects were neurologically impaired and 108 (87%) had gastroesophageal reflux. Of those, 55 (44%) had undergone prior laparoscopic fundoplication. Persistent reflux symptoms occurred in 22 (17.6%). Subjects underwent an average of 2.75 tube replacements per year and those under 2 y old had almost four. Four children (3.2%) required emergent laparotomy for intestinal perforation due to a GJ tube. These subjects were significantly younger (12 mo) than those without perforations (60.6 mo, P < 0.005). CONCLUSIONS: GJ feeding tubes were associated with notable morbidity ranging from persistent reflux to dislodgement and intestinal perforation. Together with issues of inconvenience with continuous feedings, these complications should be taken into account in children and particularly infants, in whom GJ feedings are being considered as an alternative to fundoplication.


Assuntos
Falha de Equipamento/estatística & dados numéricos , Refluxo Gastroesofágico/terapia , Perfuração Intestinal/etiologia , Intubação Gastrointestinal/efeitos adversos , Doenças do Jejuno/etiologia , Adolescente , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Perfuração Intestinal/epidemiologia , Intubação Gastrointestinal/instrumentação , Doenças do Jejuno/epidemiologia , Masculino , Falha de Tratamento
4.
J Pediatr Surg ; 59(7): 1266-1270, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38561306

RESUMO

BACKGROUND: We sought to evaluate postoperative antibiotic practices in a large population of patients with necrotizing enterocolitis (NEC) and determine whether any regimens were associated with better outcomes. METHODS: The Pediatric Health Information Systems (PHIS) database was queried to identify patients who underwent an intestinal resection for acute NEC between July, 2016 and June, 2021. Data regarding post-resection antibiotic therapy, cutaneous or intraabdominal infection, and fungal or antibiotic-resistant infection were collected. RESULTS: 130 infants at 38 children's hospitals met inclusion criteria. Postoperative antibiotics were administered for a median of 13 days. The most frequently used antibiotics were vancomycin and piperacillin/tazobactam. Antibiotic duration greater than five days was not associated with a lower incidence of infection. No antibiotic was associated with a lower incidence of any of the complications assessed, although ampicillin was associated with more infections, overall. The incidence of fungal infection and treatment with a parenteral anti-fungal medication was greater with vancomycin. No antibiotic combination was used enough to be assessed. CONCLUSIONS: Administration of antibiotics for more than five days after resection for NEC was not associated with better infectious outcomes and no single antibiotic demonstrated superior efficacy. Consistent with prior studies, fungal infections were more frequent with vancomycin. TYPE OF STUDY: Retrospective database study, level 3B. LEVEL OF EVIDENCE: II.


Assuntos
Antibacterianos , Enterocolite Necrosante , Humanos , Enterocolite Necrosante/cirurgia , Enterocolite Necrosante/tratamento farmacológico , Antibacterianos/uso terapêutico , Antibacterianos/administração & dosagem , Recém-Nascido , Masculino , Estudos Retrospectivos , Feminino , Lactente , Resultado do Tratamento , Vancomicina/uso terapêutico , Vancomicina/administração & dosagem , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Incidência , Combinação Piperacilina e Tazobactam/uso terapêutico , Combinação Piperacilina e Tazobactam/administração & dosagem
5.
J Pediatr Surg ; : 161903, 2024 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-39332974

RESUMO

BACKGROUND: Colonic atresia (CA) is associated with Hirschsprung disease (HD) in up to 10% of cases. Therefore, some surgeons elect to complete proximal diversion at the initial operation. We sought to better define the incidence of concurrent HD and evaluate practice patterns regarding diversion for CA. METHODS: The Pediatric Health Information System (PHIS) database was used to identify patients with CA from 2013 to 2022. Patients with small bowel atresia, anorectal malformation, gastroschisis, or first operation after 14 days of age were excluded. Index and subsequent operations were defined. Complications, time to enterostomy closure, and unplanned operations were evaluated. RESULTS: HD was diagnosed in 8 (9.5%) patients and 7 of these were initially diverted. Diverted and anastomosed patients were demographically similar. In the 58 (69%) patients initially diverted, 19 (33%) had an ileostomy. Continuity was restored with an ileo-colic anastomosis in 63% of diverted and 27% of primarily anastomosed patients. Of those initially managed with a colostomy, 53% ultimately had a colo-colonic anastomosis. Patients with primary anastomoses had fewer operations and received more days of parenteral nutrition. Other outcomes did not vary. CONCLUSION: In a large population of infants with CA, 9.5% had concurrent HD. Almost 70% of CA patients underwent initial diversion and only one with HD had a primary anastomosis. Patients managed with a primary anastomosis were substantially more likely to retain the proximal colonic segment, but had a similar incidence of complications. When intraoperative colonic biopsies are obtained, primary anastomosis is a safe and effective strategy for CA.

6.
J Pediatr Surg ; : 161680, 2024 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-39261185

RESUMO

INTRODUCTION: Infants with esophageal atresia and tracheoesophageal fistula (EA/TEF) are at increased risk for respiratory compromise and gastric perforation until fistula ligation. We sought to describe current practice regarding the timing of EA/TEF repair and hypothesized that age at repair is a predictor of adverse outcomes. METHODS: The Pediatric Health Information System (PHIS) database was used to identify patients with EA/TEF who underwent fistula ligation and esophago-esophagostomy at US children's hospitals from July 2016-June 2021. Patients with a repair >10 days of age, a long-gap atresia, or H-type fistula were excluded. Comorbidities including prematurity and operative congenital heart disease were noted. Outcomes including anastomotic leak, gastric perforation, and post-operative respiratory failure were assessed for association with age and day of the week of operation. RESULTS: Among 863 patients that were evaluated, the plurality of operations was on DOL 2 (36%) and 83% were on a weekday (random rate = 71%). Later operations had shorter LOS (p = 0.04) and more recurrent nerve injuries (p = 0.01). Weekend repairs were associated with equivalent outcomes. Gastric perforations occurred in 18 (2.0%) patients; 11 (61%) of these occurred after DOL 2. CONCLUSIONS: We found no significant differences in outcomes other than more recurrent nerve injury and decreased LOS with EA/TEF repair at older ages. Although repair beyond DOL 2 was safe from a respiratory standpoint, most gastric perforations occurred after this point. In the absence of contraindications or significantly reduced weekend capabilities, we recommend repair of EA/TEF by DOL 2. LEVEL OF EVIDENCE: III.

7.
Langenbecks Arch Surg ; 398(3): 463-6, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23269520

RESUMO

PURPOSE: The initial approach to complicated appendicitis in children has become increasingly nonoperative, particularly when there is presumed perforation and a localized abscess. We extended the indications for nonoperative management to include most cases other than simple appendicitis, including those with diffuse peritoneal involvement. We evaluated outcomes and sought to identify factors at the time of hospital admission that predicted an extended length of stay (LOS) with this strategy. METHODS: The records of 223 consecutive children who were managed nonoperatively for complicated appendicitis were reviewed. A conservative approach was typically pursued in those with an abscess, phlegmon, or free fluid on initial imaging studies, and diffuse tenderness, diarrhea, or significant leukocytosis after 2 days of symptoms. Interval appendectomies were performed selectively. RESULTS: The average LOS was 5.6 days (1-38), but nine subjects had a LOS of greater than 14 days. Eleven (4.9 %) required appendectomy during the initial admission. Free fluid on admission imaging studies, present in 78 % of those with an extended LOS, [odds ratio (OR) 5.5], in addition to a requirement for early nasogastric drainage (OR 24.2) and a higher band count (19 vs 15 %), was significantly associated with an extended LOS. CONCLUSIONS: An expansion of the indications for nonoperative management of complicated appendicitis yielded an acceptable average LOS and a low incidence of early appendectomy. However, a small subset of subjects had an extended LOS, and most of those had free peritoneal fluid on admission.


Assuntos
Antibacterianos/uso terapêutico , Apendicite/diagnóstico , Apendicite/terapia , Drenagem/métodos , Tempo de Internação , Adolescente , Fatores Etários , Análise Química do Sangue , Criança , Pré-Escolar , Estudos de Coortes , Terapia Combinada , Intervalos de Confiança , Feminino , Seguimentos , Hospitalização , Humanos , Contagem de Leucócitos , Masculino , Razão de Chances , Estudos Retrospectivos , Medição de Risco , Índice de Gravidade de Doença , Fatores Sexuais , Irrigação Terapêutica/métodos , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
8.
Langenbecks Arch Surg ; 397(8): 1353-7, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22382700

RESUMO

PURPOSE: The utility of negative pressure wound therapy (NPWT) in the management of adults with an open abdomen has been well documented. We reviewed our experience with NPWT in the management of infants and children with this condition. METHODS: The records of all children who were treated with NPWT for an open abdomen between March 2005 and September 2009 at a single children's hospital were reviewed. RESULTS: Twenty-five subjects were identified. They included children who developed abdominal compartment syndrome after a laparotomy (n = 12) or in whom the abdomen could not be safely closed at the time of laparotomy (n = 13). NWPT was accomplished with the vacuum-assisted closure (VAC®) system in all patients. The median duration for NPWT was 4.5 days. In 16 subjects, the abdomen was closed successfully after NPWT. In 14 children, the abdominal wall fascia was successfully approximated, and two children underwent a patch abdominal closure. But nine subjects died before an abdominal closure could be attempted. Only two (12.5%) children developed enterocutaneous fistulae. CONCLUSIONS: NPWT is a reliable tool for infants and children with an open abdomen. Wound management was facilitated and abdominal wall closure was ultimately achieved in all survivors. Enterocutaneous fistulae developed in two children, however, these were likely due to underlying bowel injury and would have occurred despite variations in management of the open abdomen.


Assuntos
Técnicas de Fechamento de Ferimentos Abdominais , Tratamento de Ferimentos com Pressão Negativa , Adolescente , Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido
9.
J Perinatol ; 42(3): 307-312, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34312472

RESUMO

OBJECTIVE: To evaluate the efficacy of dexmedetomidine as an opioid-sparing agent in infants following open thoracic or abdominal operations. METHODS: Retrospective review of postoperative neonates who received IV acetaminophen with or without dexmedetomidine. The primary outcome was opioid dosage within the first ten postoperative days. Secondary outcomes included times to extubation, full feedings and discharge. RESULTS: 112 infants met inclusion criteria. Those managed with dexmedetomidine received 1.8-4.3 times more opioid on postoperative days 1-3, had longer times to extubation and trended towards longer lengths of hospital stay than infants who were not. Opioid was dosed >0.2 ME/kg on only 23% of days when the acetaminophen dose was >40 mg/kg/day and 10% of days when the acetaminophen dose was >45 mg/kg. CONCLUSION: Dexmedetomidine may not be opioid sparing after major operations in neonates and its use delays recovery. IV acetaminophen dosed at 40 mg/kg/day or greater may yield the most substantial opioid-sparing effect.


Assuntos
Analgésicos não Narcóticos , Dexmedetomidina , Acetaminofen/uso terapêutico , Analgésicos não Narcóticos/uso terapêutico , Analgésicos Opioides/uso terapêutico , Dexmedetomidina/uso terapêutico , Humanos , Lactente , Recém-Nascido , Tempo de Internação
10.
J Pediatr Surg ; 57(1): 100-103, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34688493

RESUMO

PURPOSE: Maximizing operating room (OR) efficiency is essential for hospital cost containment and effective patient throughput. Little data is available regarding the safety and efficacy of extubation of children in the post-anesthesia care unit (PACU) by a nurse rather than in the OR. We sought to evaluate the impact of a long-standing practice of PACU extubation upon airway complications and OR efficiency. METHODS: The records of 1930 children who underwent inguinal hernia repair, laparoscopic appendectomy or pyloromyotomy at a children's hospital between July, 2018 and June, 2020 were reviewed. Extubations were performed in the OR only when the PACU was inadequately staffed or during the early months of the Covid-19 pandemic. Cases in which there was a deep extubation, a PACU hold was in effect or a patient went directly to an inpatient unit from the OR were excluded. Intra- and post-operative time metrics were recorded and emergency airway interventions were assessed. RESULTS: 1747 operations were evaluated. Time from the end of the procedure to leaving the OR ranged from 4.1 to 4.8 min when extubation was done in the PACU and was 6-9 min less than with OR extubation. (see table). There were 23 airway events (1.5% of all cases) after PACU extubation that necessitated only brief bag-mask ventilation. There were no cases of re-intubation. CONCLUSIONS: In a large population of children undergoing diverse surgical procedures, post-anesthesia care unit extubation was safe and resulted in rapid transfer of patients from the operating room after completion of their operation. Time saved because of shorter operating room times reduces hospital costs and can allow for increased throughput. Extubation in the post-anesthesia care unit may not only be as safe as operating room extubation, but may result in fewer serious airway events as patients may be less likely to have their endotracheal tube removed prematurely. LEVEL OF EVIDENCE: Treatment Study, Level III.


Assuntos
Anestesia , COVID-19 , Extubação , Criança , Humanos , Salas Cirúrgicas , Pandemias , Estudos Retrospectivos , SARS-CoV-2
11.
J Neurosurg Pediatr ; 27(5): 533-537, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33711805

RESUMO

OBJECTIVE: The authors sought to evaluate the contemporary management of pediatric open skull fractures and assess the impact of variations in antibiotic and operative management on the incidence of infectious complications. METHODS: The records of children who presented from 2009 to 2017 to 6 pediatric trauma centers with an open calvarial skull fracture were reviewed. Data collected included mechanism and anatomical site of injury; presence and depth of fracture depression; antibiotic choice, route, and duration; operative management; and infectious complications. RESULTS: Of the fractures among the 138 patients included in the study, 48.6% were frontal and 80.4% were depressed; 58.7% of patients underwent fragment elevation. The average duration of intravenous antibiotics was 4.6 (range 0-21) days. Only 53 patients (38.4%) received a single intravenous antibiotic for fewer than 4 days. and 56 (40.6%) received oral antibiotics for an average of 7.3 (range 1-20) days. Wounds were managed exclusively in the emergency department in 28.3% of patients. Two children had infectious complications, including a late-presenting hardware infection and a superficial wound infection. There were no cases of meningitis or intracranial abscess. Neither antibiotic spectrum or duration nor bedside irrigation was associated with the development of infection. CONCLUSIONS: The incidence of infectious complications in this population of children with open skull fractures was low and was not associated with the antibiotic strategy or site of wound care. Most minimally contaminated open skull fractures are probably best managed with a short duration of a single antibiotic, and emergency department closure is appropriate unless there is significant contamination or fragment elevation is necessary.


Assuntos
Fraturas Expostas/cirurgia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Fraturas Cranianas/cirurgia , Adolescente , Antibacterianos/uso terapêutico , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Complicações Pós-Operatórias/tratamento farmacológico , Infecções Relacionadas à Prótese/epidemiologia , Infecções Relacionadas à Prótese/etiologia , Estudos Retrospectivos , Centros de Traumatologia , Infecção dos Ferimentos/epidemiologia , Infecção dos Ferimentos/etiologia
12.
J Pediatr Surg ; 54(1): 60-64, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30482541

RESUMO

PURPOSE: The diagnosis of "closing" or "closed gastroschisis" is made when bowel is incarcerated within a closed or nearly closed ring of fascia, usually with associated bowel atresia. It has been described as having a high morbidity and mortality. METHODS: A retrospective review of closing gastroschisis cases (n = 53) at six children's hospitals between 2000 and 2016 was completed after IRB approval. RESULTS: A new classification system for this disease was developed to represent the spectrum of the disease: Type A (15%): ischemic bowel that is constricted at the ring but without atresia; Type B (51%): intestinal atresia with a mass of ischemic, but viable, external bowel (owing to constriction at the ring); Type C (26%): closing ring with nonviable external bowel +/- atresia; and Type D (8%): completely closed defect with either a nubbin of exposed tissue or no external bowel. Overall, 87% of infants survived, and long-term data are provided for each type. CONCLUSIONS: This new classification system better captures the spectrum of disease and describes the expected long-term results for counseling. Unless the external bowel in a closing gastroschisis is clearly necrotic, it should be reduced and evaluated later. Survival was found to be much better than previously reported. TYPE OF STUDY: Retrospective case series with no comparison group. LEVEL OF EVIDENCE: Level IV.


Assuntos
Gastrosquise/classificação , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Seguimentos , Gastrosquise/mortalidade , Gastrosquise/cirurgia , Humanos , Recém-Nascido , Atresia Intestinal/etiologia , Intestinos/cirurgia , Estudos Retrospectivos , Taxa de Sobrevida
14.
Arch Surg ; 142(3): 236-41; discussion 241, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17372047

RESUMO

HYPOTHESIS: The morbidity following treatment for perforated appendicitis in children is significant, with intra-abdominal abscess being one of the more serious complications. This can lead to prolonged hospitalizations and antibiotic administration, multiple computed tomographic scans, and invasive procedures. The purpose of our study was to determine risk factors for developing an intra-abdominal abscess following treatment for perforated appendicitis. DESIGN: Case-control study. SETTING: Four tertiary care children's hospitals. PATIENTS: Children aged 1 to 18 years with appendicitis. INTERVENTION: Multivariable logistic regression. MAIN OUTCOME MEASURES: Development of postoperative abscess, length of hospital stay, presence or absence of fever, and tolerance of diet on postoperative day 3. RESULTS: Thirty-five (13.2%) of 265 children developed an abscess. Ten factors with a bivariate P value <.20 were included in the regression model. The final multivariable model revealed only 2 factors influencing abscess development: an intraoperative fecalith (odds ratio, 8.77 [95% confidence interval, 1.50-51.40]) and diarrhea at presentation. Many factors proposed to be associated with abscess were not, including pain history, type and timing of preoperative antibiotics, abscess at operation, laparoscopic procedure, and length of antibiotics postoperatively. Thiry-seven children were discharged on or before postoperative day 3. Another 21 children were afebrile and tolerating a diet at that time but remained in the hospital. There were no significant differences between the 2 groups. None of the early-discharge group developed an abscess, and 2 of those remaining in the hospital developed an abscess (P = .06). CONCLUSIONS: Clinical factors commonly thought to be predictive of abscess formation following perforated appendicitis were not reliable predictors of this outcome. Our results suggest that if children are afebrile and eating on postoperative day 3 they can be discharged with a low rate of abscess development.


Assuntos
Abscesso Abdominal/etiologia , Apendicectomia/efeitos adversos , Apendicite/cirurgia , Adolescente , Criança , Pré-Escolar , Intervalos de Confiança , Feminino , Seguimentos , Humanos , Incidência , Lactente , Tempo de Internação , Masculino , Complicações Pós-Operatórias , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Caracteres Sexuais
15.
Am Surg ; 73(10): 1079-82, 2007 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17983086

RESUMO

Although neutropenia is recognized as a risk factor for infection and compromised wound healing, there are little data regarding the specific impact of neutropenia on morbidity and mortality after placement of implanted central venous catheters (CVC). We conducted a retrospective review of children with a diagnosis of acute lymphocytic leukemia or aplastic anemia who received a CVC over a 5-year period. The absolute neutrophil count immediately before catheter placement was recorded. Three hundred eight catheters were placed in 195 patients with acute lymphocytic leukemia and 15 with aplastic anemia. Absolute neutrophil count was less than 0.5 x 10(9)/L in 105 cases (Group 1). The incidence of CVC removal for all causes and for infection within 100 days in Group 1 was 17.1 per cent and 11.4 per cent, respectively, compared with 7.9 per cent (P = 0.01) and 1.5 per cent (P < 0.0001) with absolute neutrophil count 0.5 x 10(9)/L or greater (Group 2). Infections included two cases of mucormycosis with one death. Ports were more likely than Hickman catheters (C. R. Bard Inc., Murray Hill, NJ) to be removed for all causes (P = 0.01) and for infection (P = 0.04). The placement of implanted central venous catheters in neutropenic children was associated with substantial infectious morbidity and one death. When possible, CVC, particularly ports, should be avoided in the presence of neutropenia.


Assuntos
Anemia Aplástica/terapia , Cateterismo Venoso Central/efeitos adversos , Infecções/epidemiologia , Neutropenia/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Anemia Aplástica/mortalidade , Cateteres de Demora/efeitos adversos , Criança , Remoção de Dispositivo , Humanos , Modelos Logísticos , Mucormicose/epidemiologia , Neutropenia/etiologia , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Cicatrização
16.
J Pediatr Surg ; 52(7): 1152-1155, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27887684

RESUMO

OBJECTIVE: To determine the incidence of intestinal mucosal injury before and after transfusions in premature infants. STUDY DESIGN: Urine was collected throughout the hospital stay of 62 premature infants and specimens obtained within 24h before and after transfusion were assayed for intestinal fatty acid binding protein (iFABP). A urinary iFABP:creatinine ratio (iFABPu:Cru) of 2.0pg/nmol was considered elevated. RESULT: Forty-nine infants were transfused. iFABPu:Cru was elevated following 71 (75.6%) of 94 transfusions for which urine was available. In 51 (71.8%) of these, iFABPu:Cru was also elevated prior to the transfusion. Among four cases of transfusion-associated NEC, iFABPu was elevated following every sentinel transfusion and prior to three of them. CONCLUSION: Subclinical intestinal mucosal injury is frequent following blood transfusions in premature infants and, when present, usually precedes transfusion. This suggests that transfusion may not be a primary mediator of intestinal injury so much as anemia and its associated conditions. LEVEL OF EVIDENCE: Prognosis study/level 3.


Assuntos
Transfusão de Eritrócitos/efeitos adversos , Proteínas de Ligação a Ácido Graxo/urina , Recém-Nascido Prematuro/urina , Transfusão de Plaquetas/efeitos adversos , Enterocolite Necrosante/etiologia , Enterocolite Necrosante/urina , Humanos , Incidência , Lactente , Recém-Nascido , Doenças do Recém-Nascido , Doenças do Prematuro/urina
17.
Transl Stroke Res ; 7(2): 97-102, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25994284

RESUMO

Germinal matrix intraventricular hemorrhage (IVH) is the most common type of intracranial hemorrhage observed in preterm neonates. It is a precursor of poor neurocognitive development, cerebral palsy, and death. The pathophysiology is not well defined, but damage to the fragile germinal matrix vasculature may be due to free radicals generated during inflammation and as a consequence of ischemia followed by reperfusion. Assessment of the oxidative stress status in these infants is therefore important. Urinary allantoin concentration was measured in preterm neonates as a marker of oxidative stress associated with IVH. Urine was collected from 44 preterm neonates at four time points between 24 and 72 hours of life (HOL), and the allantoin content was determined by gas chromatography mass spectrometry (GCMS). Records were retrospectively reviewed, and the incidence and severity of IVH was categorized as follows: no IVH (n = 24), mild (grade 1-2) IVH (n = 13), and severe (grade 3-4) IVH (n = 7). Neonates with severe IVH showed significantly elevated allantoin levels vs subjects with no IVH from 36 HOL (0.098 ± 0.013 µmol and 0.043 ± 0.007 µmol, respectively, p = 0.002). The allantoin concentration remained elevated even at 72 HOL (0.079 ± 0.014 µmol and 0.033 ± 0.008 µmol, respectively, p = 0.021). There were no significant differences in allantoin levels in the no IVH and mild IVH groups. IVH was diagnosed by head imaging on average at about 11th postnatal day. Urinary allantoin levels were significantly elevated during the first 3 days of life in the neonates subsequently diagnosed with severe IVH, suggesting that oxidative stress might be a crucial factor in IVH pathogenesis. Further studies are needed to assess the usefulness of urinary allantoin in early identification of preterm infants at risk for or with severe IVH and monitoring of the response to interventions designed to prevent or treat it.


Assuntos
Alantoína/urina , Hemorragia Cerebral/urina , Análise de Variância , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro/urina , Masculino , Estatísticas não Paramétricas
18.
Am Surg ; 68(12): 1072-4, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12516811

RESUMO

After appendectomy for perforated appendicitis children have traditionally been managed with intravenous broad-spectrum antibiotics for 5 to 10 days and then until fever and leukocytosis have resolved. We prospectively evaluated a protocol of hospital discharge on oral antibiotics when oral intake is tolerated-regardless of fever or leukocytosis-in a consecutive series of 80 children between one and 15 years of age who underwent appendectomy (38 open and 42 laparoscopic) for perforated appendicitis. At discharge subjects began a 7-day course of oral trimethoprim/sulfamethoxazole and metronidazole. Patients were discharged between 2 and 18 days postoperatively (mean 5.3 days). Sixty-six were discharged on oral antibiotics, and 28 of these had persistent fever or leukocytosis. Two patients (2.5%) developed postoperative intra-abdominal abscesses while inpatients. Wound infections developed in seven patients (8.8%) four of whom were on intravenous antibiotics. Among the 66 children who were discharged on oral antibiotics without having had an inpatient infectious complication there were three wound infections (4.4%). None of these patients had a fever or leukocytosis at discharge. We conclude that after appendectomy for perforated appendicitis children may be safely discharged home on oral antibiotics when enteral intake is tolerated regardless of fever or leukocytosis.


Assuntos
Antibacterianos , Anti-Infecciosos/administração & dosagem , Apendicectomia , Apendicite/complicações , Apendicite/tratamento farmacológico , Quimioterapia Combinada/administração & dosagem , Perfuração Intestinal/etiologia , Metronidazol/administração & dosagem , Combinação Trimetoprima e Sulfametoxazol/administração & dosagem , Administração Oral , Adolescente , Apendicite/cirurgia , Criança , Pré-Escolar , Árvores de Decisões , Esquema de Medicação , Nutrição Enteral , Feminino , Febre/etiologia , Humanos , Lactente , Perfuração Intestinal/microbiologia , Leucocitose/etiologia , Masculino , Alta do Paciente , Estudos Prospectivos , Ruptura Espontânea , Infecção da Ferida Cirúrgica/etiologia , Resultado do Tratamento
19.
Curr Surg ; 60(1): 89-93, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14972320

RESUMO

PURPOSE: The acquisition and organization of information about surgical resident performance, as well as the assessment of the educational value of different rotations, is cumbersome and time consuming. The additional requirement by the Accreditation Council of Graduate Medical Education (ACGME) to assess General Competencies in the Outcome Project has multiplied the paperwork and workload demanded from each program director and residency coordinator. The purpose of our study was to simplify the collection of information and to organize it in a way that would fulfill the requirements of the Outcome Project. METHODS: We developed an Internet-based application for maintaining a database of residents, faculty, rotations, and their evaluations. RESULTS: The modular design allows flexibility in the selection of different tools that can be added at the discretion of the program director. The use of this application has facilitated the assessment process. Evaluations are instantly available for review. CONCLUSIONS: The General Competencies of any resident can be easily demonstrated, compared, and presented in an organized fashion that allows quick reaction to problems and facilitates compliance with the Outcome Project with little additional work for the residency staff.


Assuntos
Competência Clínica , Cirurgia Geral/educação , Internet , Internato e Residência , Estados Unidos
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