Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Curing HIV: Seeking to Target and Clear Persistent Infection.

Margolis, David M; Archin, Nancie M; Cohen, Myron S; Eron, Joseph J; Ferrari, Guido; Garcia, J Victor; Gay, Cynthia L; Goonetilleke, Nilu; Joseph, Sarah B; Swanstrom, Ronald; Turner, Anne-Marie W; Wahl, Angela.

Cell ; 181(1): 189-206, 2020 04 02.

Artigo em Inglês | MEDLINE | ID: mdl-32220311

2.

The Effects of Human Immunodeficiency Virus Type 1 (HIV-1) Antigen-Expanded Specific T-Cell Therapy and Vorinostat on Persistent HIV-1 Infection in People With HIV on Antiretroviral Therapy.

Gay, Cynthia L; Hanley, Patrick J; Falcinelli, Shane D; Kuruc, JoAnn D; Pedersen, Susan M; Kirchherr, Jennifer; Raines, Samuel L M; Motta, Cecilia M; Lazarski, Chris; Chansky, Pamela; Tanna, Jay; Shibli, Abeer; Datar, Anushree; McCann, Chase D; Sili, Uluhan; Ke, Ruian; Eron, Joseph J; Archin, Nancie; Goonetilleke, Nilu; Bollard, Catherine M; Margolis, David M.

J Infect Dis ; 229(3): 743-752, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38349333

3.

CD3 downregulation identifies high-avidity human CD8 T cells.

Clutton, Genevieve T; Weideman, Ann Marie K; Mischell, Melissa A; Kallon, Sallay; Conrad, Shayla Z; Shaw, Fiona R; Warren, Joanna A; Lin, Lin; Kuruc, JoAnn D; Xu, Yinyan; Gay, Cynthia M; Armistead, Paul M; G Hudgens, Michael; Goonetilleke, Nilu P.

Clin Exp Immunol ; 215(3): 279-290, 2024 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-37950348

4.

OMIP-087: Thirty-two parameter mass cytometry panel to assess human CD4 and CD8 T cell activation, memory subsets, and helper subsets.

Sponaugle, Alexis; Abad-Fernandez, Maria; Goonetilleke, Nilu.

Cytometry A ; 103(3): 184-188, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36470845

5.

Reduced Endometrial Ascension and Enhanced Reinfection Associated With Immunoglobulin G Antibodies to Specific Chlamydia trachomatis Proteins in Women at Risk for Chlamydia.

Liu, Chuwen; Hufnagel, Katrin; O'Connell, Catherine M; Goonetilleke, Nilu; Mokashi, Neha; Waterboer, Tim; Tollison, Tammy S; Peng, Xinxia; Wiesenfeld, Harold C; Hillier, Sharon L; Zheng, Xiaojing; Darville, Toni.

J Infect Dis ; 225(5): 846-855, 2022 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-34610131

6.

HIV-1 vaccines: let's get physical.

Goonetilleke, Nilu; McMichael, Andrew J.

Immunity ; 38(3): 410-3, 2013 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-23521882

7.

Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection.

Peng, Binghao J; Carlson, Jonathan M; Liu, Michael K P; Gao, Feng; Goonetilleke, Nilu; McMichael, Andrew J; Borrow, Persephone; Gilmour, Jill; Heath, Sonya L; Hunter, Eric; Bansal, Anju; Goepfert, Paul A.

J Virol ; 92(19)2018 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-30021907

8.

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak, Gustavo H; Sanders-Buell, Eric; Chenine, Agnes-Laurence; Eller, Michael A; Goonetilleke, Nilu; Thomas, Rasmi; Leviyang, Sivan; Harbolick, Elizabeth A; Bose, Meera; Pham, Phuc; Oropeza, Celina; Poltavee, Kultida; O'Sullivan, Anne Marie; Billings, Erik; Merbah, Melanie; Costanzo, Margaret C; Warren, Joanna A; Slike, Bonnie; Li, Hui; Peachman, Kristina K; Fischer, Will; Gao, Feng; Cicala, Claudia; Arthos, James; Eller, Leigh A; O'Connell, Robert J; Sinei, Samuel; Maganga, Lucas; Kibuuka, Hannah; Nitayaphan, Sorachai; Rao, Mangala; Marovich, Mary A; Krebs, Shelly J; Rolland, Morgane; Korber, Bette T; Shaw, George M; Michael, Nelson L; Robb, Merlin L; Tovanabutra, Sodsai; Kim, Jerome H.

PLoS Pathog ; 13(7): e1006510, 2017 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-28759651

9.

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection.

Kijak, Gustavo H; Sanders-Buell, Eric; Chenine, Agnes-Laurence; Eller, Michael A; Goonetilleke, Nilu; Thomas, Rasmi; Leviyang, Sivan; Harbolick, Elizabeth A; Bose, Meera; Pham, Phuc; Oropeza, Celina; Poltavee, Kultida; O'Sullivan, Anne Marie; Billings, Erik; Merbah, Melanie; Costanzo, Margaret C; Warren, Joanna A; Slike, Bonnie; Li, Hui; Peachman, Kristina K; Fischer, Will; Gao, Feng; Cicala, Claudia; Arthos, James; Eller, Leigh A; O'Connell, Robert J; Sinei, Samuel; Maganga, Lucas; Kibuuka, Hannah; Nitayaphan, Sorachai; Rao, Mangala; Marovich, Mary A; Krebs, Shelly J; Rolland, Morgane; Korber, Bette T; Shaw, George M; Michael, Nelson L; Robb, Merlin L; Tovanabutra, Sodsai; Kim, Jerome H.

PLoS Pathog ; 13(9): e1006620, 2017 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-28910384

10.

A Reproducible, Objective Method Using MitoTracker® Fluorescent Dyes to Assess Mitochondrial Mass in T Cells by Flow Cytometry.

Clutton, Genevieve; Mollan, Katie; Hudgens, Michael; Goonetilleke, Nilu.

Cytometry A ; 95(4): 450-456, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30576071

11.

HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals.

Sung, Julia A; Patel, Shabnum; Clohosey, Matthew L; Roesch, Lauren; Tripic, Tamara; Kuruc, JoAnn D; Archin, Nancie; Hanley, Patrick J; Cruz, C Russell; Goonetilleke, Nilu; Eron, Joseph J; Rooney, Clio M; Gay, Cynthia L; Bollard, Catherine M; Margolis, David M.

Mol Ther ; 26(10): 2496-2506, 2018 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-30249388

12.

Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.

Demers, Korey R; Makedonas, George; Buggert, Marcus; Eller, Michael A; Ratcliffe, Sarah J; Goonetilleke, Nilu; Li, Chris K; Eller, Leigh Anne; Rono, Kathleen; Maganga, Lucas; Nitayaphan, Sorachai; Kibuuka, Hannah; Routy, Jean-Pierre; Slifka, Mark K; Haynes, Barton F; McMichael, Andrew J; Bernard, Nicole F; Robb, Merlin L; Betts, Michael R.

PLoS Pathog ; 12(8): e1005805, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27486665

13.

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.

Liu, Donglai; Wang, Chu; Hora, Bhavna; Zuo, Tao; Goonetilleke, Nilu; Liu, Michael K P; Berrong, Mark; Ferrari, Guido; McMichael, Andrew J; Bhattacharya, Tanmoy; Perelson, Alan S; Gao, Feng.

Retrovirology ; 14(1): 46, 2017 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-29017536

14.

Expansion of Inefficient HIV-Specific CD8 T Cells during Acute Infection.

Eller, Michael A; Goonetilleke, Nilu; Tassaneetrithep, Boonrat; Eller, Leigh Anne; Costanzo, Margaret C; Johnson, Susan; Betts, Michael R; Krebs, Shelly J; Slike, Bonnie M; Nitayaphan, Sorachai; Rono, Kathleen; Tovanabutra, Sodsai; Maganga, Lucas; Kibuuka, Hannah; Jagodzinski, Linda; Peel, Sheila; Rolland, Morgane; Marovich, Mary A; Kim, Jerome H; Michael, Nelson L; Robb, Merlin L; Streeck, Hendrik.

J Virol ; 90(8): 4005-4016, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26842474

15.

Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.

Hancock, Gemma; Yang, Hongbing; Yorke, Elisabeth; Wainwright, Emma; Bourne, Victoria; Frisbee, Alyse; Payne, Tamika L; Berrong, Mark; Ferrari, Guido; Chopera, Denis; Hanke, Tomas; Mothe, Beatriz; Brander, Christian; McElrath, M Juliana; McMichael, Andrew; Goonetilleke, Nilu; Tomaras, Georgia D; Frahm, Nicole; Dorrell, Lucy.

PLoS Pathog ; 11(2): e1004658, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25723536

16.

Natural T Cell-mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study.

Hayward, Andrew C; Wang, Lili; Goonetilleke, Nilu; Fragaszy, Ellen B; Bermingham, Alison; Copas, Andrew; Dukes, Oliver; Millett, Elizabeth R C; Nazareth, Irwin; Nguyen-Van-Tam, Jonathan S; Watson, John M; Zambon, Maria; Johnson, Anne M; McMichael, Andrew J.

Am J Respir Crit Care Med ; 191(12): 1422-31, 2015 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-25844934

17.

Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo.

Smith, Nicola M G; Mlcochova, Petra; Watters, Sarah A; Aasa-Chapman, Marlene M I; Rabin, Neil; Moore, Sally; Edwards, Simon G; Garson, Jeremy A; Grant, Paul R; Ferns, R Bridget; Kashuba, Angela; Mayor, Neema P; Schellekens, Jennifer; Marsh, Steven G E; McMichael, Andrew J; Perelson, Alan S; Pillay, Deenan; Goonetilleke, Nilu; Gupta, Ravindra K.

Clin Infect Dis ; 61(1): 120-8, 2015 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-25778749

18.

Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation.

Liu, Donglai; Zuo, Tao; Hora, Bhavna; Song, Hongshuo; Kong, Wei; Yu, Xianghui; Goonetilleke, Nilu; Bhattacharya, Tanmoy; Perelson, Alan S; Haynes, Barton F; McMichael, Andrew J; Gao, Feng.

Retrovirology ; 11: 101, 2014 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-25407514

19.

Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

Ritchie, Adam John; Cai, Fangping; Smith, Nicola M G; Chen, Sheri; Song, Hongshuo; Brackenridge, Simon; Abdool Karim, Salim S; Korber, Bette T; McMichael, Andrew J; Gao, Feng; Goonetilleke, Nilu.

Retrovirology ; 11: 69, 2014 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-25212771

20.

Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners.

Pala, Pietro; Serwanga, Jennifer; Watera, Christine; Ritchie, Adam J; Moodie, Zoe; Wang, Maggie; Goonetilleke, Nilu; Birabwa, Ester; Hughes, Peter; Senkaali, David; Nakiboneka, Ritah; Grosskurth, Heiner; Haynes, Bart; McMichael, Andrew; Kaleebu, Pontiano.

J Virol ; 87(16): 9053-63, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23760253

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