Variants of SARS-CoV-2: Influences on the Vaccines' Effectiveness and Possible Strategies to Overcome Their Consequences.

The immune response elicited by the current COVID-19 vaccinations declines with time, especially among the immunocompromised population. Furthermore, the emergence of novel SARS-CoV-2 variants, particularly the Omicron variant, has raised serious concerns about the efficacy of currently available vaccines in protecting the most vulnerable people. Several studies have reported that vaccinated people get breakthrough infections amid COVID-19 cases. So far, five variants of concern (VOCs) have been reported, resulting in successive waves of infection. These variants have shown a variable amount of resistance towards the neutralising antibodies (nAbs) elicited either through natural infection or the vaccination. The spike (S) protein, membrane (M) protein, and envelope (E) protein on the viral surface envelope and the N-nucleocapsid protein in the core of the ribonucleoprotein are the major structural vaccine target proteins against COVID-19. Among these targets, S Protein has been extensively exploited to generate effective vaccines against COVID-19. Hence, amid the emergence of novel variants of SARS-CoV-2, we have discussed their impact on currently available vaccines. We have also discussed the potential roles of S Protein in the development of novel vaccination approaches to contain the negative consequences of the variants' emergence and acquisition of mutations in the S Protein of SARS-CoV-2. Moreover, the implications of SARS-CoV-2's structural proteins were also discussed in terms of their variable potential to elicit an effective amount of immune response.

Violence Against Healthcare Workers at Primary Care Centers in Dammam and Al Khobar, Eastern Province, Saudi Arabia, 2019.

PURPOSE: Workplace violence is common throughout the world. It causes many serious problems in the healthcare sector, where it significantly impacts healthcare workers, the services provided, and organizations as a whole. However, few studies have investigated these issues in Saudi Arabia. This study examined the prevalence of violence against healthcare workers at primary care centers in Dammam and Al Khobar, in the Eastern Province of Saudi Arabia. The study also assessed the types, perpetrators, perceived causes, and consequences related to such violence. Here, the aim was to understand how healthcare workers responded to violence and gauge their awareness of a reporting system. PATIENTS AND METHODS: A total of 360 healthcare workers (180 each from primary care centers in Dammam and Al Khobar) were invited to complete structured, self-administered questionnaires. As such, this study employed a cross-sectional analytical design. RESULTS: The prevalence of workplace violence among all participating health workers was 46.9%, with approximately 90% of these workers reporting verbal violence, 34.3% having been subject to intimidation, and 3% reporting physical violence. Approximately 75% reported that violent events were initiated by patients, while 45.6% reported that the events were initiated by patients' companions. Healthcare workers' reactions included reporting events to their supervisors or the police, but 46.7% said they did nothing; the most common reason was perceived inefficacy. Finally, only 36.4% of all participants were aware of a violence reporting system. CONCLUSION: This study showed that healthcare workers were commonly exposed to different forms of violence, but often either did not react to it or did not report it. Further, there was relatively little awareness of how to manage and report workplace violence, thus indicating the need for healthcare workers to receive relevant education and training. A national program should also be established to track and prevent workplace violence.