Detalhe da pesquisa
1.
Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog®.
Regul Toxicol Pharmacol
; 109: 104497, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31610222
2.
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 112(19): E2543-52, 2015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25918415
3.
Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.
Bioorg Med Chem
; 20(15): 4838-47, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22743085
4.
A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane.
Anal Biochem
; 414(1): 14-22, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21382336
5.
Effect of the protonation state of the titratable residues on the inhibitor affinity to BACE-1.
Biochemistry
; 49(34): 7255-63, 2010 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20687525
6.
Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor.
Anal Biochem
; 391(1): 39-44, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19435596
7.
Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library.
J Med Chem
; 51(12): 3449-59, 2008 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18494455
8.
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.
Bioorg Med Chem
; 16(6): 2955-67, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18194867
9.
Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation.
Biochem J
; 398(3): 393-8, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16737445
10.
Powerful protein binders from designed polypeptides and small organic molecules--a general concept for protein recognition.
Angew Chem Int Ed Engl
; 50(8): 1823-7, 2011 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21328648
11.
Aliskiren displays long-lasting interactions with human renin.
Naunyn Schmiedebergs Arch Pharmacol
; 385(2): 219-24, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22193701
12.
Experimental validation of a fragment library for lead discovery using SPR biosensor technology.
J Biomol Screen
; 16(1): 15-25, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21149860
13.
Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 15(12): 4057-68, 2007 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17449253
14.
Phenylglycine as a novel P2 scaffold in hepatitis C virus NS3 protease inhibitors.
Bioorg Med Chem
; 15(3): 1448-74, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17113777
15.
Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3.
Bioorg Med Chem
; 14(2): 544-59, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16213143
16.
Easy-to-execute carbonylations: microwave synthesis of acyl sulfonamides using Mo(CO)(6) as a solid carbon monoxide source.
J Org Chem
; 70(8): 3094-8, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15822969
17.
Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors.
J Mol Recognit
; 16(4): 203-12, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12898670