Detalhe da pesquisa
1.
Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition.
Brain
; 144(5): 1396-1408, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33724342
2.
Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 40: 116163, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932711
3.
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models.
J Immunol
; 202(10): 2888-2906, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30988116
4.
Inhibition of Bruton's tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease.
Acta Neuropathol
; 140(4): 535-548, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32761407
5.
A randomized, double-blind, placebo-controlled phase 1 study of multiple ascending doses of subcutaneous M1095, an anti-interleukin 17A/F nanobody, in moderate-to-severe psoriasis.
J Am Acad Dermatol
; 81(1): 196-203, 2019 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926369
6.
Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg Med Chem Lett
; 28(21): 3419-3424, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290988
7.
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg Med Chem Lett
; 28(17): 2939-2944, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30122225
8.
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.
Bioorg Med Chem Lett
; 28(20): 3307-3311, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30243592
9.
Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol Pharmacol
; 91(3): 208-219, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28062735
10.
Btk inhibition treats TLR7/IFN driven murine lupus.
Clin Immunol
; 164: 65-77, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26821304
11.
Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
Proc Natl Acad Sci U S A
; 110(39): 15776-81, 2013 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24019486
12.
Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells.
J Immunol
; 188(5): 2244-53, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22266280
13.
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
J Immunol
; 186(2): 969-76, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21148801
14.
Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locus.
J Immunol
; 184(3): 1309-16, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20038639
15.
Human T-bet+ B cell development is associated with BTK activity and suppressed by evobrutinib.
JCI Insight
; 7(16)2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35852869
16.
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses.
J Exp Med
; 201(4): 615-26, 2005 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15728239
17.
SUMOylation attenuates c-Maf-dependent IL-4 expression.
Eur J Immunol
; 40(4): 1174-84, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20127678
18.
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
ChemMedChem
; 16(24): 3653-3662, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582626
19.
Bruton's Tyrosine Kinase Inhibition Promotes Myelin Repair.
Brain Plast
; 5(2): 123-133, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33282676
20.
Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration-QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers.
Clin Transl Sci
; 13(2): 325-336, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31654487