[Contents of 6-keto-prostaglandin F1 alpha and thromboxane B2 in the blood of patients with bronchial asthma]. / Soderzhanie 6-keto-prostaglandina F1 alfa i tromboksana B2 v krovi bol'nykh bronkhial'noi astmoi.

There is a relationship between severity of bacterial bronchial asthma clinical symptoms and plasma 6-keto-PGF1 alpha, TxB2: in moderate disease against grave one as well as in clinical versus subclinical forms (remission) relevant indices are reduced. On the one hand elevated content of blood 6-keto-PGF1 alpha seems compensatory rising in response to TxB2 bronchoconstriction. On the other hand, it impairs microcirculation and enhances mediators of inflammation, promotes exudation and edema of bronchoalveolar mucosa, thus contributing to obstruction.

[Blood levels of 6-keto-prostaglandin F1alpha, thromboxane and prostaglandin F2alpha in patients with bronchial asthma]. / Soderzhanie 6-ketoprostaglandina F1alfa, tromboksana i prostaglandina F2alfa v krovi bolnykh bronkhialnoi astmoi.

The study revealed the relation of bronchial asthma (bacterial variant) clinical pattern to plasma levels of PGF2 alpha, 6-keto-PGF1 alpha and TxB2. In remission of the disease the above indices are lower. Severe asthma remission is characterized by higher levels of 6-keto-PGF1 alpha and TxB2 than moderate asthma one, demonstrates a tendency to growing PGF2 alpha levels. A rise in PGF2 alpha and TxB2 in manifest asthma points to their participation in bronchospasm formation suggesting an active role of these bronchoconstrictors in asthma pathogenesis. Higher levels of 6-keto-PGF1 alpha are of a compensary nature in the pathogenesis of PGF2 alpha and TxB2 bronchoconstrictory action, and of damaging nature contributing to the formation of bronchial mucosa edema and bronchial gland hypersecretion.