Exploring Attitudes Toward "Sugar Relationships" Across 87 Countries: A Global Perspective on Exchanges of Resources for Sex and Companionship.

The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures showed adequate psychometric properties in all languages (except the Persian version of ASR-YWMS). Results partially supported our hypotheses and were consistent with previous theoretical considerations and empirical evidence on human mating. For example, at the individual level, sociosexual orientation, traditional gender roles, and pathogen prevalence were significant predictors of both ASR-YWMS and ASR-OMWS. At the country level, gender inequality and parasite stress positively predicted the ASR-YWMS. However, being a woman negatively predicted the ASR-OMWS, but positively predicted the ASR-YWMS. At country-level, ingroup favoritism and parasite stress positively predicted the ASR-OMWS. Furthermore, significant cross-subregional differences were found in the openness to sugar relationships (both ASR-YWMS and ASR-OMWS scores) across subregions. Finally, significant differences were found between ASR-YWMS and ASR-OMWS when compared in each subregion. The ASR-YWMS was significantly higher than the ASR-OMWS in all subregions, except for Northern Africa and Western Asia.

Possible kidney-lung cross-talk in COVID-19: in silico modeling of SARS-CoV-2 infection.

BACKGROUND: Publicly available genomics datasets have grown drastically during the past decades. Although most of these datasets were initially generated to answer a pre-defined scientific question, their repurposing can be useful when new challenges such as COVID-19 arise. While the establishment and use of experimental models of COVID-19 are in progress, the potential hypotheses for mechanisms of onset and progression of COVID-19 can be generated by using in silico analysis of known molecular changes during COVID-19 and targets for SARS-CoV-2 invasion. METHODS: Selecting condition: COVID-19 infection leads to pneumonia and mechanical ventilation (PMV) and associated with acute kidney injury (AKI). There is increasing data demonstrating mechanistic links between AKI and lung injury caused by mechanical ventilation. Selecting targets: SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) for cell entry. We hypothesized that expression of ACE2 and TMPRSS2 would be affected in models of AKI and PMV. We therefore evaluated expression of ACE2 and TMPRSS2 as well as other novel molecular players of AKI and AKI-lung cross-talk in the publicly available microarray datasets GSE6730 and GSE60088, which represent gene expression of lungs and kidneys in mouse models of AKI and PMV, respectively. RESULTS: Expression of COVID-19 related genes ACE2 and TMPRSS2 was downregulated in lungs after 6 h of distant AKI effects. The expression of ACE2 decreased further after 36 h, while expression of TMPRSS2 recovered. In kidneys, both genes were downregulated by AKI, but not by distant lung injury. We also identified 53 kidney genes upregulated by PMV; and 254 lung genes upregulated by AKI, 9 genes of which were common to both organs. 3 of 9 genes were previously linked to kidney-lung cross-talk: Lcn2 (Fold Change (FC)Lung (L) = 18.6, FCKidney (K) = 6.32), Socs3 (FCL = 10.5, FCK = 10.4), Inhbb (FCL = 6.20, FCK = 6.17). This finding validates the current approach and reveals 6 new candidates, including Maff (FCL = 7.21, FCK = 5.98). CONCLUSIONS: Using our in silico approach, we identified changes in COVID-19 related genes ACE2 and TMPRSS2 in traditional mouse models of AKI and kidney-lung cross-talk. We also found changes in new candidate genes, which could be involved in the combined kidney-lung injury during COVID-19.

The Strategies of Parental Involvement in Adolescents' Education and Extracurricular Activities.

Different parental strategies in education are bound to produce various effects: not all of these strategies are equally productive in their application. At the same time, the impact of parental involvement in general education on their children's extracurricular activities has not been thoroughly studied. This article attempts to fill this gap by analyzing the relationship between strategies of parental involvement in education and adolescents' participation in extracurricular activities. The data source for this study were parents whose children attend general education institutions (N = 3,887; Mage of children = 12.4, SD = 3.1; 55.6% female). A latent class analysis identified three categories of parental participation in education: "Intrusive", "Supervisory", and "Detached". Each category showed different patterns of involvement from primary to high school, distinguished by the type of extracurricular participation encouraged by parents. In primary school, children of "Intrusive" parents attended the highest number of extracurricular activities. In secondary school, they attended fewer activities compared to the children of "Supervisory" parents. Children of "Supervisory" parents often chose to participate in activities on their own, and continued to attend the selected activity, or change activity on their own initiative. The children of "Detached" parents were less involved in extracurricular activities in primary school. In some cases, they chose their own extracurricular activities as they grew older. The study demonstrates that parental involvement is related to adolescents' participation in extracurricular activities. Parents' strategies should be considered instrumental as they produce a variety of different outcomes, depending upon the adolescents' age and type of activities. The identified strategies may serve as a basis for recommendations for development of parental competencies, consultations, and family education.

Novel Protective Role of Nicotinamide Phosphoribosyltransferase in Acetaminophen-Induced Acute Liver Injury in Mice.

Acetaminophen overdose is the most common cause of acute liver injury (ALI) or acute liver failure in the United States. Its pathogenetic mechanisms are incompletely understood. Additional studies are warranted to identify new genetic risk factors for more mechanistic insights and new therapeutic target discoveries. The objective of this study was to explore the role and mechanisms of nicotinamide phosphoribosyltransferase (NAMPT) in acetaminophen-induced ALI. C57BL/6 Nampt gene wild-type (Nampt+/+), heterozygous knockout (Nampt+/-), and overexpression (NamptOE) mice were treated with overdose of acetaminophen, followed by histologic, biochemical, and transcriptomic evaluation of liver injury. The mechanism of Nampt in acetaminophen-induced hepatocytic toxicity was also explored in cultured primary hepatocytes. Three lines of evidence have convergently demonstrated that acetaminophen overdose triggers the most severe oxidative stress and necrosis, and the highest expression of key necrosis driving genes in Nampt+/- mice, whereas the effects in NamptOE mice were least severe relative to Nampt+/+ mice. Treatment of P7C3-A20, a small chemical molecule up-regulator of Nampt, ameliorated acetaminophen-induced mouse ALI over the reagent control. These findings support the fact that NAMPT protects against acetaminophen-induced ALI.

Down-regulation of placental neuropilin-1 in fetal growth restriction.

BACKGROUND: Fetal growth restriction (FGR) is associated with adverse outcomes extending from fetal to adult life, and thus, constitutes a major health care challenge. Fetuses with progressive growth restriction show increasing impedance in the umbilical artery flow, which may become absent during end-diastole. Absent end-diastolic flow (AEDF) is associated with adverse perinatal outcomes including stillbirths and perinatal asphyxia. Placentas from such pregnancies demonstrate deficient fetoplacental vascular branching. Current evidence, moreover, indicates an antiangiogenic state in maternal circulation in several pregnancy complications including preeclampsia, small-for-gestational-age births, fetal death, and preterm labor. The angiogenic mediators in maternal circulation are predominantly of placental origin. Information, however, on the role of specific proangiogenic and antiangiogenic mechanisms operating at the placental level remains limited. Elucidation of these placenta-specific angiogenic mechanisms will not only extend our understanding of the causal pathway for restricted fetal growth but may also lead to the development of biomarkers that may allow early recognition of FGR. OBJECTIVE: We sought to test the hypothesis that fetoplacental angiogenic gene expression is altered in pregnancies complicated with FGR and umbilical artery Doppler AEDF. STUDY DESIGN: Placental samples were collected from FGR pregnancies complicated with umbilical artery Doppler AEDF (study group, n = 7), and from uncomplicated pregnancies (control group, n = 7), all delivered by cesarean during the last trimester of pregnancy. Angiogenic oligonucleotide microarray analysis was performed and was corroborated by quantitative real-time polymerase chain reaction, Western blot analysis, and immunohistochemistry. The Student t test with Bonferroni correction was used with P < .05 considered statistically significant. Independent groups t test was used to analyze the immunostain intensity scores with a P < .05 considered statistically significant. RESULTS: Our microarray results showed that among several differentially expressed angiogenic genes in the growth-restricted group, only the down-regulation of neuropilin (NRP)-1 was most significant (P < .0007). Quantitative real-time polymerase chain reaction confirmed a significantly lower NRP-1 gene expression in the FGR group than in the control group (mean ± SD (ˆ)cycle threshold: 0.624 ± 0.55 and 1.325 ± 0.84, respectively, P = .04). Western blot validated significantly lower NRP-1 protein expression in the FGR group than in the control group (mean ± SD NRP-1/ß-actin ratio: 0.13 ± 0.04 and 0.34 ± 0.05, respectively, P < .001). Finally, immunohistochemistry of placental villi further corroborated a significantly decreased expression of NRP-1 in the FGR group (P = .006). CONCLUSION: The study demonstrated significant down-regulation of placental NRP-1 expression in FGR pregnancies complicated with AEDF in umbilical artery. As NRP-1 is known to promote sprouting angiogenesis, its down-regulation may be involved in the deficient vascular branching observed in FGR placentas suggesting the presence of an antiangiogenic state. Further studies may elucidate such a causal role and may lead to the development of novel diagnostic and therapeutic tools.

Identification of new biomarkers for Acute Respiratory Distress Syndrome by expression-based genome-wide association study.

BACKGROUND: Accumulated to-date gene microarray data on Acute Respiratory Distress Syndrome (ARDS) in the Gene Expression Omnibus (GEO) represent a rich source for identifying new unsuspected targets and mechanisms of ARDS. The recently developed expression-based genome-wide association study (eGWAS) for analysis of GEO data was successfully used for analysis of gene expression of comparatively noncomplex adipose tissue, 75 % of which is represented by adipocytes. Although lung tissue is more heterogenic and does not possess a prevalent cell type for driving gene expression patterns, we hypothesized that eGWAS of ARDS samples will generate biologically meaningful results. METHODS: The eGWAS was conducted according to (Proc Natl Acad Sci U S A 109:7049-7054, 2012) and genes were ranked according to p values of chi-square test. RESULTS: The search of GEO retrieved 487 ARDS related entries. These entries were filtered for multiple qualitative and quantitative conditions and 219 samples were selected: mouse n sham/ARDS = 67/92, rat n = 13/13, human cells n = 11/11, canine n = 6/6 with the following ARDS model distributions: mechanical ventilation (MV)/cyclic stretch n = 11; endotoxin (LPS) treatment n = 8; MV + LPS n = 3; distant organ injury induced ARDS n = 3; chemically induced ARDS n = 2; Staphylococcus aureus induced ARDS n = 2; and one experiment each for radiation and shock induced ARDS. The eGWAS of this dataset identified 42 significant (Bonferroni threshold P < 1.55 × 10(-6)) genes. 66.6 % of these genes, were associated previously with lung injury and include the well known ARDS genes such as IL1R2 (P = 4.42 × 10(-19)), IL1ß (P = 3.38 × 10(-17)), PAI1 (P = 9.59 × 10(-14)), IL6 (P = 3.57 × 10(-12)), SOCS3 (P = 1.05 × 10(-10)), and THBS1 (P = 2.01 × 10(-9)). The remaining genes were new ARDS candidates. Expression of the most prominently upregulated genes, CLEC4E (P = 4.46 × 10(-14)) and CD300LF (P = 2.31 × 10(-16)), was confirmed by real time PCR. The former was also validated by in silico pathway analysis and the latter by Western blot analysis. CONCLUSIONS: Our first in the field application of eGWAS in ARDS and utilization of more than 120 publicly available microarray samples of ARDS not only justified applicability of eGWAS to complex lung tissue, but also discovered 14 new candidate genes which associated with ARDS. Detailed studies of these new candidates might lead to identification of unsuspected evolutionarily conserved mechanisms triggered by ARDS.

Mental health literacy for social phobia in Ghana: Investigation of gender stereotypes and previous experience for recognition rates and prejudice.

BACKGROUND: Mental health literacy (MHL) research has been of substantial interest internationally. Nevertheless, the interplay between beliefs, attitudes, previous experience with mental disorders, and knowledge of Ghanaians on specific mental disorders remains to be understood. The present study explored the interconnectedness between gender stereotypes, prejudice, previous experience with social phobia, and MHL among the general population in Ghana. METHOD: Six hundred and one Ghanaians were recruited for an online experimental study design using a survey approach for data gathering. Respondents were randomly assigned to one of the two conditions (i.e., male and female vignettes) depicting symptoms of social phobia for a hypothetical person. Participants further completed self-reported measures including gender stereotypes (based on Ambivalent Sexism Inventory) and prejudice. RESULTS: Results revealed a 15.5% recognition rate for social phobia. Recognition rates of social phobia did not differ by the experimental condition or by the gender of participants. However, personal experience of social phobia was positively related to an increased likelihood of correctly labeling social phobia among men in the female vignette condition, whereas correct recognition of social phobia was negatively related to prejudice among women in the male vignette condition. In the male vignette condition, men with more hostile sexism attitudes toward men exhibited more prejudice toward their hypothetical male counterpart. In contrast, women with hostile sexism attitudes toward men exhibited less prejudice, but greater benevolent sexism attitudes toward men was associated with more prejudice toward the hypothetical male in the vignette. CONCLUSION: Findings from the current study emphasize the role of the cultural milieu in shaping effective mental health interventions. The results also have implications for promoting MHL to reduce prejudice in Ghana and other developing countries in the region.

Collective action against corruption in Western and non-Western countries: cross-cultural implications of the Axiological-Identitary Collective Action Model.

People sometimes protest government corruption, yet our current understanding of why they do so is culturally constrained. Can we separate pancultural factors influencing people's willingness to protest government corruption from factors culturally specific to each socioecological context? Surprisingly little cross-cultural data exist on this important question. To fill this gap, we performed a cross-cultural test of the Axiological-Identitary Collective Action Model (AICAM) regarding the intention to protest against corruption. As a collective action framework, AICAM integrates three classical antecedents of collective action (injustice, efficacy, identity) with axiological variables (ideology and morality). A total sample of 2,316 participants from six countries (Nigeria, Russia, India, Spain, United States, Germany) in a multilevel analysis of AICAM predictions showed that the positive relationship of the intention to protest corruption with moral obligation, system-based anger, and national identification can be considered pancultural. In contrast, the relationships between system justification and perceived efficacy are culturally specific. System justification negatively predicted the intention to participate only in countries with high levels of wealth, while perceived efficacy positively predicted it only in countries perceived as less corrupt. These findings highlight the importance of accounting features of socioecology and separating pancultural from culture-specific effects in understanding collective action.

Meta-analysis of molecular response of kidney to ischemia reperfusion injury for the identification of new candidate genes.

BACKGROUND: Accumulated to-date microarray data on ischemia reperfusion injury (IRI) of kidney represent a powerful source for identifying new targets and mechanisms of kidney IRI. In this study, we conducted a meta-analysis of gene expression profiles of kidney IRI in human, pig, rat, and mouse models, using a new scoring method to correct for the bias of overrepresented species. The gene expression profiles were obtained from the public repositories for 24 different models. After filtering against inclusion criteria 21 experimental settings were selected for meta-analysis and were represented by 11 rat models, 6 mouse models, and 2 models each for pig and human, with a total of 150 samples. Meta-analysis was conducted using expression-based genome-wide association study (eGWAS). The eGWAS results were corrected for a rodent species bias using a new weighted scoring algorithm, which favors genes with unidirectional change in expression in all tested species. RESULTS: Our meta-analysis corrected for a species bias, identified 46 upregulated and 1 downregulated genes, of which 26 (55%) were known to be associated with kidney IRI or kidney transplantation, including LCN2, CCL2, CXCL1, HMOX1, ICAM1, ANXA1, and TIMP1, which justified our approach. Pathway analysis of our candidates identified "Acute renal failure panel" as the most implicated pathway, which further validates our new method. Among new IRI candidates were 10 novel (<5 published reports related to kidney IRI) and 11 new candidates (0 reports related to kidney IRI) including the most prominent candidates ANXA2, CLDN4, and TYROBP. The cross-species expression pattern of these genes allowed us to generate three workable hypotheses of kidney IRI, one of which was confirmed by an additional study. CONCLUSIONS: Our first in the field kidney IRI meta-analysis of 150 microarray samples, corrected for a species bias, identified 10 novel and 11 new candidate genes. Moreover, our new meta-analysis correction method improved gene candidate selection by identifying genes that are model and species independent, as a result, function of these genes can be directly extrapolated to the disease state in human and facilitate translation of potential diagnostic or therapeutic properties of these candidates to the bedside.

Social Worldviews Predict the General Factor of Paranormal and Generic Conspiracist Beliefs.

Even though wide access to any warranted information in the modern age, the problem of unfounded belief is still relevant, since these beliefs often lead to negative consequences (e.g., vaccination refusal, homeopathic treatment, etc.). The aim of this study was testing the relationship of social worldviews with paranormal beliefs and conspiracy beliefs. We assumed dimensionality hypothesis based on functional standpoint that there should be a general factor (underlying all the domains of paranormal beliefs and generic conspiracist beliefs), which has associations with the social worldviews as well. Derived our analysis from the survey of 228 participants (Mage = 30.6, SD = 11.7), we found that (a) the structure of paranormal and generic conspiracist beliefs can be described by a bifactor model; (b) the general factor of paranormal and generic conspiracist beliefs in the bifactor model was positively associated with global belief in just world and dangerous worldview; (c) paranormal beliefs were positively associated with global belief in just world and negatively associated with competitive worldview; (d) generic conspiracist beliefs were positively associated with dangerous worldview, competitive worldview, and zero-sum game belief; (e) contrary to our hypotheses, there was no evidence for any negative association of paranormal beliefs with dangerous worldview or zero-sum game belief and for any negative association of generic conspiracist beliefs with global belief in just world. We claim that the unfounded beliefs can be of some functional nature, demonstrating a connection with social worldviews, which opens up new perspectives for considering this problem within the framework of social psychology.

Evaluating the integration hypothesis: A meta-analysis of the ICSEY project data using two new methods.

The Integration Hypothesis states that acculturating migrants who adopt the integration strategy (i.e. being doubly engaged, in both their heritage culture and in the larger national society) will have better psychological and socio-cultural adaptation than those who adopt any other strategy (Assimilation, Separation or Marginalization). This hypothesis was supported in the original evaluation of the ICSEY project data, using the mean adaptation scores for individuals in the four acculturation clusters. This conclusion was further supported by an analysis that used scores that were derived from the two underlying dimensions. This paper further evaluates this hypothesis meta-analytically using two new methods: Cultural Involvement and Cultural Preference; and Euclidean Distance. The results showed that these two methods provided support for the integration hypothesis, for both psychological adaptation and socio-cultural adaptation. The pattern of relationships was stronger for positive than for negative indicators of adaptation. Theoretical and practical implications of the results are discussed.

Development and Validation of the Revised Multicultural Ideology Scale in Germany and Luxembourg.

A revised version of the Multicultural Ideology Scale (rMCI) is currently being developed to measure endorsement of multiculturalism in different cultural contexts. This study, which is part of a wider cross-cultural research project, presents the first assessment of the rMCI scale in the German language. The measure aims to cover several attitudinal dimensions of multiculturalism, relevant to the integration of different ethnocultural groups: Cultural Maintenance, Equity/Inclusion, Social interaction, Essentialistic Boundaries, Extent of Differences, and Consequences of Diversity. Two independent datasets were acquired from Germany (N = 382) and Luxembourg (N = 148) to estimate the factor structure of the rMCI using different confirmatory factor analysis techniques. The findings suggest that a four-factor solution, including Cultural Maintenance, Equity/Inclusion, Social interaction, and Consequences of Diversity, was the best fit for the data. Most of these subscales demonstrated adequate psychometric properties (internal consistency, convergent, and discriminant validity). The four-factor model of the rMCI was partially invariant across the two ethnic groups and full measurement invariance was established across gender.

Basic values as a motivational framework relating individual values with acculturation strategies among Arab immigrants and refugees across different settlement contexts.

There is a lack of systematic acculturation research on the motivations underpinning the behavior of migrants, which could explain how they acculturate and adapt to their new country of residence. This paper examines the link between values, using the Schwartz Theory of Basic Human Values, and acculturation strategies among Arab immigrant and refugee groups across different settlement contexts. The results of Study 1 (Arab immigrants; N = 456) showed, as hypothesized, positive links between strategies and values: the integration strategy with conservation, social focus, self-protection, and self-transcendence values; assimilation with openness to change, personal focus, and growth values; and separation with conservation, social focus, and self-protection. These findings were generally repeated in Study 2 (Syrian refugees; N = 415) except that integration was not associated with self-transcendence and that assimilation was positively linked to self-enhancement instead of openness to change. Our analyses indicated that acculturation preferences are mainly related to motivational values, rather than to different settlement contexts in both samples; however, assimilation seems to be more associated to context than values among the refugee sample. Implications of the findings to the acculturation literature are discussed.

Transcriptional analysis of infiltrating T cells in kidney ischemia-reperfusion injury reveals a pathophysiological role for CCR5.

Although T cells have been shown to play a direct role in kidney ischemia-reperfusion injury (IRI), little is known about the underlying mechanisms. We hypothesized that studying the transcriptional responses in kidney-infiltrating T cells would help elucidate novel therapeutic targets for kidney IRI. Unilateral renal pedicle clamping for 45 min was performed in male C57BL/6 mice, and CD3(+) T cells were isolated from the kidney and purified. Transcriptional activities of T cell were measured by array-based PCR compared between ischemic kidneys and contralateral nonischemic kidneys. Among total of 89 genes analyzed, 24, 22, 24, and 37 genes were significantly changed at 6 h, day 3, day 10, and day 28 after IRI. Genes associated with cytokines, chemokines, and costimulatory molecules were upregulated. Pathway analysis identified CC motif chemokine receptor 5 (CCR5) as a candidate pathophysiological pathway. CCR5 upregulation was validated at the protein level, and CCR5 blockade improved renal function after kidney IRI. Using discovery techniques to identify transcriptional responses in purified kidney-infiltrating cells enabled the elucidation of novel mechanisms and therapeutic targets for IRI.

Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.

BACKGROUND: The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood. OBJECTIVE: We sought to determine whether subjects with AD prone to disseminated viral skin infections have defects in their IFN responses. METHODS: GeneChip profiling was used to identify differences in gene expression of PBMCs from patients with ADEH(+) compared with patients with AD without a history of eczema herpeticum (ADEH(-)) and nonatopic controls. Key differences in protein expression were verified by enzyme-linked immunosorbent spot assay and/or ELISA. Clinical relevance was further demonstrated by a mouse model of disseminated viral skin infection and genetic association analysis for genetic variants in IFNG and IFNGR1 and ADEH among 435 cases and controls. RESULTS: We demonstrate by global gene expression analysis selective transcriptomic changes within the IFN superfamily of PBMCs from subjects with ADEH(+) reflecting low IFN-γ and IFN-γ receptor gene expression. IFN-γ protein production was also significantly lower in patients with ADEH(+) (n = 24) compared with patients with ADEH(-) (n = 20) and nonatopic controls (n = 20). IFN-γ receptor knockout mice developed disseminated viral skin infection after epicutaneous challenge with vaccinia virus. Genetic variants in IFNG and IFNGR1 single nucleotide polymorphisms (SNPs) were significantly associated with ADEH (112 cases, 166 controls) and IFN-γ production: a 2-SNP (A-G) IFNGR1 haplotype (rs10457655 and rs7749390) showed the strongest association with a reduced risk of ADEH+ (13.2% ADEH(+) vs 25.5% ADEH(-); P = .00057). CONCLUSION: Patients with ADEH(+) have reduced IFN-γ production, and IFNG and IFNGR1 SNPs are significantly associated with ADEH(+) and may contribute to an impaired immune response to herpes simplex virus.

An Adaptationist Framework to Examine Intergroup Contact.

Background: Many culturally-plural societies like Canada or Russia seek ways to manage their cultural diversity in order to promote harmony among coexisting groups. The social sciences have long viewed intergroup contact as a beneficial intervention to achieve such harmony. Objective: This paper proposes an adaptationist framework within which to explain how and why intergroup contact contributes to the positive and negative outcomes for individuals who live together in a plural society. We employed this framework in a case study that may serve as an example of the conceptualization and analysis of these issues in international research. Its structural framework included both positive and negative contact and the role of this contact in the distribution of intercultural and psychological adaptation among a large representative sample of the Canadian population. Design: We used a correlational design with a representative sample of Canadians from a survey carried out by Environics in 2019, which was stratified according to the most current population statistics. The total sample was 3,111 persons age 18 and over and included the largest racialised groups in the country. Results: Our main finding was that intergroup contact (both positive and negative) related to both psychological and intercultural adaptation. These findings have implications for improving intercultural relations, especially through the role of positive contact. Conclusion: The experience of negative contact (e.g., discrimination) in the near term is an important factor in undermining both forms of adaptation. Nonetheless, while intergroup contact can bring both positive and negative experiences during intercultural interactions, it leads to mutual adaptation over time.

Validation of the Revised Multicultural Ideology Scale (MCI-r) in the UK.

As worldwide migration continues to grow, valid and reliable instruments are needed to assess the psychological processes that influence the successful management of intercultural relations in different sociopolitical contexts. In this study, we test whether the original Multicultural Ideology Scale (MCI) required a revision to remain 'fit for purpose' in the current culturally plural context of the UK (MCI-r). Specifically, six subscales are proposed to underlie the construct of a multicultural ideology: Cultural Maintenance, Equity/Inclusion, Social interaction, Essentialistic Boundaries, Extent of Differences, and Consequences of Diversity. With data from 300 UK nationals, we tested the psychometric properties of the MCI-r using various confirmatory factor analysis techniques to estimate the scale's factor structure followed by convergent and discriminant validity tests. The results indicated that a 4-factor solution (Cultural Maintenance, Equity/Inclusion, Social interaction, and Consequences of Diversity) fitted the data best. All four subscales demonstrated adequate internal consistency as well as convergent and discriminant validity. All four subscales were also negatively correlated with a right-wing political orientation, whilst especially Social Interaction and Consequences of Diversity were positively associated with intergroup contact frequency across domains (work, family and friends and/or acquaintances). Finally, UK participants with personal migratory experiences reported a stronger belief in positive consequences of multiculturalism and more support for Social Interactions between members of different ethnic groups. Overall, findings provide first insights into the applicability of the MCI-r as a reliable and valid tool for the assessment of multiculturalism within the present UK context.

More Similarity if Different, More Difference if Similar: Assimilation, Colorblindness, Multiculturalism, Polyculturalism, and Generalized and Specific Negative Intergroup Bias.

The creation of a social climate where all ethnic groups can harmoniously coexist is a central challenge for many countries today. Should we emphasize similarities and common ground or, conversely, recognize that there are important differences between groups? The current study examined relations between diversity ideologies (assimilation, colorblindness, multiculturalism, polyculturalism) and generalized and specific intergroup bias (against Chechens, Belarusians, Uzbeks, Chinese, and Jews and Muslims) among ethnic Russians (N = 701). In Study 1, colorblindness (ignoring differences) and polyculturalism (emphasizing interconnectivity) were associated with lower generalized intergroup bias and lower bias against Chechens, Uzbeks, and Chinese, but not Belarusians. Bias against Belarusians was lower among those who endorsed multiculturalism (emphasizing differences). In Study 2, multiculturalism was associated with higher implicit bias when the target was a Chechen but in general more proximal variables (positive or negative contact experience and perceived group similarity) were more robust predictors of intergroup bias than diversity ideologies. In Study 3, colorblindness and polyculturalism were related to lower levels of fearful attitudes against Muslims. Colorblindness was also associated with lower levels of Antisemitism in contrast to multiculturalism that had an opposite association. We place these results in the context of cultural distance and existing cultural stereotypes about different groups among the majority of Russians. The strengths and weaknesses of each diversity ideology for the mainstream cultural group are discussed. The results of the current study suggest that the most fruitful strategy for mainstream cultural groups for maintaining harmonious intergroup relations in diverse societies might be that of optimal distinctiveness.

Contextual factors predicting compliance behavior during the COVID-19 pandemic: A machine learning analysis on survey data from 16 countries.

Voluntary isolation is one of the most effective methods for individuals to help prevent the transmission of diseases such as COVID-19. Understanding why people leave their homes when advised not to do so and identifying what contextual factors predict this non-compliant behavior is essential for policymakers and public health officials. To provide insight on these factors, we collected data from 42,169 individuals across 16 countries. Participants responded to items inquiring about their socio-cultural environment, such as the adherence of fellow citizens, as well as their mental states, such as their level of loneliness and boredom. We trained random forest models to predict whether someone had left their home during a one week period during which they were asked to voluntarily isolate themselves. The analyses indicated that overall, an increase in the feeling of being caged leads to an increased probability of leaving home. In addition, an increased feeling of responsibility and an increased fear of getting infected decreased the probability of leaving home. The models predicted compliance behavior with between 54% and 91% accuracy within each country's sample. In addition, we modeled factors leading to risky behavior in the pandemic context. We observed an increased probability of visiting risky places as both the anticipated number of people and the importance of the activity increased. Conversely, the probability of visiting risky places increased as the perceived putative effectiveness of social distancing decreased. The variance explained in our models predicting risk ranged from < .01 to .54 by country. Together, our findings can inform behavioral interventions to increase adherence to lockdown recommendations in pandemic conditions.

Warmth and competence perceptions of key protagonists are associated with containment measures during the COVID-19 pandemic: Evidence from 35 countries.

It is crucial to understand why people comply with measures to contain viruses and their effects during pandemics. We provide evidence from 35 countries (Ntotal = 12,553) from 6 continents during the COVID-19 pandemic (between 2021 and 2022) obtained via cross-sectional surveys that the social perception of key protagonists on two basic dimensions-warmth and competence-plays a crucial role in shaping pandemic-related behaviors. Firstly, when asked in an open question format, heads of state, physicians, and protest movements were universally identified as key protagonists across countries. Secondly, multiple-group confirmatory factor analyses revealed that warmth and competence perceptions of these and other protagonists differed significantly within and between countries. Thirdly, internal meta-analyses showed that warmth and competence perceptions of heads of state, physicians, and protest movements were associated with support and opposition intentions, containment and prevention behaviors, as well as vaccination uptake. Our results have important implications for designing effective interventions to motivate desirable health outcomes and coping with future health crises and other global challenges.