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1.
Khirurgiia (Mosk) ; (2): 86-90, 2023.
Artigo em Russo | MEDLINE | ID: mdl-36748874

RESUMO

The article is devoted to infusion therapy with Reamberin 1.5% (Meglumine sodium succinate) in patients with various traumatic injuries. The authors substantiate the relevance and significance of this issue. Specifics and purposes of therapy are considered. The authors reviewed national studies devoted to clinical aspects and determined the main directions of therapy in emergency patients with mechanical injuries, burns, traumatic brain injury and cognitive impairment caused by combat trauma. Moreover, experimental studies of protective properties of Reamberin under combined action of cold, vibration and immobilization, as well as acute massive blood loss are analyzed.


Assuntos
Militares , Humanos , Succinatos/uso terapêutico , Antioxidantes/uso terapêutico , Meglumina/uso terapêutico
2.
Vopr Onkol ; 57(4): 470-4, 2011.
Artigo em Russo | MEDLINE | ID: mdl-22191236

RESUMO

Malignant peritoneal effusions often arise in patients with ovarian carcinoma. They are a hazardous complication of cancer. Systematic intraperitoneal chemotherapy is not necessarily followed by long-term remission and may even induce untoward side effects. Intraperitoneal interleukin-2 (IL-2) and IL-2/lymphokine-activated killers (LAK) biotherapy showed high efficacy in treatment of ovarian carcinoma patients suffering from peritoneal effusions. The objective effect was 80.1% and 82.6%, respectively. Our results suggest that intraperitoneal biotherapy may be extended to dealing with malignant peritoneal effusions in ovarian carcinoma.


Assuntos
Antineoplásicos/administração & dosagem , Líquido Ascítico/efeitos dos fármacos , Terapia Biológica/métodos , Interleucina-2/administração & dosagem , Células Matadoras Ativadas por Linfocina , Neoplasias Epiteliais e Glandulares/terapia , Neoplasias Ovarianas/terapia , Adulto , Idoso , Líquido Ascítico/patologia , Carcinoma Epitelial do Ovário , Feminino , Humanos , Infusões Parenterais , Pessoa de Meia-Idade , Neoplasias Epiteliais e Glandulares/tratamento farmacológico , Neoplasias Epiteliais e Glandulares/patologia , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/patologia , Resultado do Tratamento
3.
Bull Exp Biol Med ; 148(5): 794-6, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20396794

RESUMO

Clinical efficiency of low dose Roncoleukin was studied in 30 patients with metastatic exudative pleurisy. Intrapleural therapy proved to be highly effective (overall effect reached 84%), was well tolerated, and improved patients' quality of life.


Assuntos
Interleucina-2/uso terapêutico , Neoplasias , Pleurisia , Adulto , Idoso , Feminino , Humanos , Imunofenotipagem , Injeções Intralesionais , Interleucina-2/administração & dosagem , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/patologia , Pleurisia/tratamento farmacológico , Pleurisia/etiologia , Resultado do Tratamento
4.
Anesteziol Reanimatol ; (4): 3-6, 2003.
Artigo em Russo | MEDLINE | ID: mdl-14524007

RESUMO

The pronouncement degree and dynamics of pain syndrome were assessed after surgeries in the abdominal cavity organs with regard for a nature of the analgetic component of premedication and of the postoperative analgesic therapy (n = 155). The administration of analgesics before extra-traumatic surgeries was found to be compulsory in order to prevent the onset of a persistent postoperative pain syndrome. A combination of non-steroid anti-inflammatory drugs, i.e. ketonal, and of a high-efficiency agonist of opiate mu-receptors, i.e. bupranal, was acknowledged as most effective in coping with this task. It was demonstrated that the application of "the forestalling analgesia" by ketonal (100 mg in 30 min before the beginning of moderate- and mild-trauma surgical interventions and immediately after the finalization of such surgeries) contributed to an essentially lower pronouncement degree of the postoperative pain syndrome and made the administration of narcotic analgesics unnecessary. Finally, it is pointed out that promedol could not be regarded as a drug ensuring a safe prophylaxis of the central sensitization and hyperalgesia.


Assuntos
Analgésicos não Narcóticos/uso terapêutico , Analgésicos Opioides/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/prevenção & controle , Pré-Medicação/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Analgésicos não Narcóticos/administração & dosagem , Analgésicos Opioides/administração & dosagem , Anti-Inflamatórios não Esteroides/administração & dosagem , Criança , Esquema de Medicação , Humanos , Pessoa de Meia-Idade , Medição da Dor
6.
Biomed Khim ; 49(1): 2-7, 2003.
Artigo em Russo | MEDLINE | ID: mdl-14569865

RESUMO

Literature data summarizing new approaches and importance of early ovary cancer diagnostics have been reviewed. Alpha-feta-protein (AFP) and SA125 were the most reliable markers for determination of early ovary cancer stages. Nevertheless, these markers don't reflect the disease stage, malignance and they don't possess sufficient specificity. New methodical approaches have recently been introduced. They include combination of 2-D electrophoresis with mass-spectrometry. These methods allow to inventory and identify almost all proteins of various tissues. Using these methods for scanning proteins from biopsies of ovary cancer tissues new markers have been discovered.


Assuntos
Biomarcadores Tumorais/análise , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/metabolismo , Proteômica/métodos , Antígeno Ca-125/análise , Eletroforese em Gel Bidimensional , Feminino , Humanos , Espectrometria de Massas , alfa-Fetoproteínas/análise
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