Detalhe da pesquisa
1.
SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML.
Blood
; 119(17): 4026-33, 2012 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22411868
2.
Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice.
Blood
; 116(22): 4600-11, 2010 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20696946
3.
Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor.
Blood
; 113(17): 4074-7, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483393
4.
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Blood
; 114(19): 4197-208, 2009 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-19734451
5.
Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro.
Br J Haematol
; 144(6): 865-74, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19183186
6.
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations.
Exp Hematol
; 35(10): 1522-6, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17889720
7.
The oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model.
Oncogene
; 22(30): 4642-7, 2003 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12879008
8.
GP130 activation induces myeloma and collaborates with MYC.
J Clin Invest
; 124(12): 5263-74, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25384216
9.
ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer.
Cancer Res
; 70(13): 5368-78, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20551051
10.
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration.
J Exp Med
; 206(9): 1957-70, 2009 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19687226
11.
Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment.
Proc Natl Acad Sci U S A
; 104(11): 4594-9, 2007 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17360569
12.
Flt3-dependent transformation by inactivating c-Cbl mutations in AML.
Blood
; 110(3): 1004-12, 2007 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17446348
13.
FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.
Blood
; 105(12): 4792-9, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15718420
14.
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor.
Blood
; 102(2): 646-51, 2003 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12663439