Detalhe da pesquisa
1.
Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 6): 1124-37, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23695257
2.
Generation of an antibody toolbox to characterize hERG.
Biochem Biophys Res Commun
; 431(1): 70-5, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23277102
3.
Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).
Acta Crystallogr D Biol Crystallogr
; 67(Pt 2): 119-23, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245533
4.
Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor.
Front Pharmacol
; 12: 699535, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35126098
5.
DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome.
ACS Chem Biol
; 14(1): 37-49, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30452219
6.
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
Structure
; 14(4): 713-23, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16615913
7.
A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.
Mol Endocrinol
; 20(4): 809-30, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16373399
8.
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.
Elife
; 62017 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28195038
9.
Systematic investigation of halogen bonding in protein-ligand interactions.
Angew Chem Int Ed Engl
; 50(1): 314-8, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184410
10.
Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.
J Med Chem
; 56(23): 9789-801, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24224654
11.
Halogen bonding at the active sites of human cathepsinâ L and MEK1 kinase: efficient interactions in different environments.
ChemMedChem
; 6(11): 2048-54, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21898833
12.
Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design.
J Mol Biol
; 397(2): 508-19, 2010 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20132826
13.
Structural and biophysical characterization of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers.
Bioconjug Chem
; 16(3): 504-17, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15898716
14.
Structural, kinetic, and thermodynamic analysis of the binding of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers to the extracellular domain of the receptor IFNAR2.
Bioconjug Chem
; 16(3): 518-27, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15898717