Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.

Wang, Bo; Zhu, Sheng; Guo, Miao; Ma, Run-Dong; Tang, Ya-Ling; Nie, Ya-Xiong; Gu, Hong-Feng.

Mol Med ; 30(1): 35, 2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-38454322

2.

Discovery of highly potent PARP7 inhibitors for cancer immunotherapy.

Yang, Jieping; Liu, Beibei; Yan, Wenxin; Zhao, Xiaolin; Wang, Chenghao; Zhu, Qihua; Zou, Yi; Xu, Yungen; Gu, Hongfeng.

Bioorg Chem ; 148: 107469, 2024 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-38781669

3.

Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor.

Li, Xiang; Zhuang, Yuan-Yuan; Wu, Lei; Xie, Ming; Gu, Hong-Feng; Wang, Bo; Tang, Xiao-Qing.

Neuropsychobiology ; 79(2): 119-130, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31550727

4.

Hydrogen Sulfide Inhibits Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior by Upregulation of Sirt-1: Involvement in Suppression of Hippocampal Endoplasmic Reticulum Stress.

Liu, Shu-Yun; Li, Dan; Zeng, Hai-Ying; Kan, Li-Yuan; Zou, Wei; Zhang, Ping; Gu, Hong-Feng; Tang, Xiao-Qing.

Int J Neuropsychopharmacol ; 20(11): 867-876, 2017 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-28482013

5.

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cognitive Dysfunction by Inhibition of Reactive Aldehydes Involving Upregulation of ALDH2.

Li, Min; Zhang, Ping; Wei, Hai-Jun; Li, Man-Hong; Zou, Wei; Li, Xiang; Gu, Hong-Feng; Tang, Xiao-Qing.

Int J Neuropsychopharmacol ; 20(4): 305-315, 2017 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-27988490

6.

Hydrogen sulfide inhibits MPP⁺-induced aldehyde stress and endoplasmic reticulum stress in PC12 cells: involving upregulation of BDNF.

Xiao, Fan; Zhang, Ping; Chen, Ai-Hua; Wang, Chun-Yan; Zou, Wei; Gu, Hong-Feng; Tang, Xiao-Qing.

Exp Cell Res ; 348(1): 106-114, 2016 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-27641114

7.

Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide.

Chen, Ying; Zhou, Cheng-Fang; Xiao, Fan; Huang, Hong-Lin; Zhang, Ping; Gu, Hong-Feng; Tang, Xiao-Qing.

Clin Exp Pharmacol Physiol ; 44(5): 595-601, 2017 May.

Artigo em Inglês | MEDLINE | ID: mdl-28251688

8.

Arecoline Induces Neurotoxicity to PC12 Cells: Involvement in ER Stress and Disturbance of Endogenous H2S Generation.

Jiang, Jia-Mei; Wang, Li; Gu, Hong-Feng; Wu, Keng; Xiao, Fan; Chen, Ying; Guo, Run-Min; Tang, Xiao-Qing.

Neurochem Res ; 41(8): 2140-8, 2016 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-27255601

9.

H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway.

Gao, Shenglan; Li, Wenting; Zou, Wei; Zhang, Ping; Tian, Ying; Xiao, Fan; Gu, Hongfeng; Tang, Xiaoqing.

Acta Biochim Biophys Sin (Shanghai) ; 47(11): 915-24, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26423115

10.

Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.

Huang, Lei; Shao, Jialu; Lai, Wenwen; Gu, Hongfeng; Yang, Jieping; Shi, Shi; Wufoyrwoth, Shepherd; Song, Zhe; Zou, Yi; Xu, Yungen; Zhu, Qihua.

Eur J Med Chem ; 267: 116159, 2024 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-38325007

11.

Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Gu, Hongfeng; Yan, Wenxin; Yang, Jieping; Liu, Beibei; Zhao, Xiaolin; Wang, Hongxia; Xu, Wenbo; Wang, Chenghao; Chen, Yang; Dong, Qiuyi; Zhu, Qihua; Xu, Yungen; Zou, Yi.

J Med Chem ; 67(3): 1932-1948, 2024 Feb 08.

Artigo em Inglês | MEDLINE | ID: mdl-38059836

12.

Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Xu, Yongling; Du, Huijie; Guo, Weibo; Liu, Beibei; Yan, Wenxin; Zhang, Chi; Qin, Long; Huang, Jingling; Wang, Hongxia; Wu, Shiqi; Ren, Weijie; Zou, Yi; Wang, Jie; Zhu, Qihua; Xu, Yungen; Gu, Hongfeng.

J Med Chem ; 67(5): 4083-4099, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38348878

13.

Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy.

Zhai, Jinxia; Wang, Chao; Jin, Liang; Liu, Fangtao; Xiao, Yinzhu; Gu, Hongfeng; Liu, Mingjie; Chen, Yongjun.

Mol Neurobiol ; 2023 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-37605097

14.

ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.

Wang, Yuan-Mei; Tang, Huang; Tang, Ya-Jie; Liu, Juan; Yin, Yu-Fang; Tang, Ya-Ling; Feng, Yao-Guang; Gu, Hong-Feng.

J Adv Res ; 2023 Nov 04.

Artigo em Inglês | MEDLINE | ID: mdl-37931656

15.

Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors.

Gu, Hongfeng; Yan, Wenxin; Wang, Yong; Xu, Wenbo; Huang, Lei; Yang, Jieping; Zhai, Bingxin; Wang, Hong; Su, Yupei; Zhu, Qihua; Liu, Beibei; Hao, Haiping; Zou, Yi; Xu, Yungen.

J Med Chem ; 66(1): 473-490, 2023 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-36576395

16.

Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway.

Zhan, Kebin; Ning, Min; Wang, Chunyan; Tang, Yonghong; Gu, Hongfeng; Yan, Canqun; Tang, Xiaoqing.

Acta Biochim Biophys Sin (Shanghai) ; 48(8): 771-3, 2016 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-27261780

17.

Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders.

Wang, Yuan-Mei; Qiu, Ming-Yue; Liu, Qing; Tang, Huang; Gu, Hong-Feng.

Brain Res Bull ; 168: 138-145, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33400955

18.

Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification.

Wang, Yuan-Mei; Tan, Mo-Ye; Zhang, Rong-Jie; Qiu, Ming-Yue; Fu, You-Sheng; Xie, Xue-Jiao; Gu, Hong-Feng.

Front Physiol ; 12: 777386, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-35126174

19.

Lipophagy in atherosclerosis.

Liu, Qing; Wang, Yuan-Mei; Gu, Hong-Feng.

Clin Chim Acta ; 511: 208-214, 2020 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-33096029

20.

Autophagy in chronic stress induced atherosclerosis.

Li, Na; Zhang, Ru-Xin; Xie, Xue-Jiao; Gu, Hong-Feng.

Clin Chim Acta ; 503: 70-75, 2020 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-31945340

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