RESUMO
After publication of the original article [1] it was noted that the captions relating to Figs. 2 and 3 had been interchanged.
RESUMO
BACKGROUND: Temporal expression extraction and normalization is a fundamental and essential step in clinical text processing and analyzing. Though a variety of commonly used NLP tools are available for medical temporal information extraction, few work is satisfactory for multi-lingual heterogeneous clinical texts. METHODS: A novel method called TEER is proposed for both multi-lingual temporal expression extraction and normalization from various types of narrative clinical texts including clinical data requests, clinical notes, and clinical trial summaries. TEER is characterized as temporal feature summarization, heuristic rule generation, and automatic pattern learning. By representing a temporal expression as a triple
Assuntos
Heurística , Armazenamento e Recuperação da Informação , Prontuários Médicos , Processamento de Linguagem Natural , Reconhecimento Automatizado de Padrão , HumanosRESUMO
OBJECTIVE: To evaluate the efficacy of azithromycin in preventing congenital syphilis. METHOD: Five pregnant women with syphilis who were allergic to penicillin were given azithromycin, 1 g daily orally or intravenously, in different hospitals. The duration of the therapy ranged from 1 day to 10 days. A second course of therapy was provided at 28 weeks gestation. The babies were given a physical examination and blood test for serum rapid plasma reagin test (RPR), treponema pallidum hemagglutination test (TPHA), and fluorescent treponemal antibody adsorption test (FTA-ABS-19-sIgM) within three months after birth. RESULTS: Five infants born to these mothers developed skin rashes. Four of the infants had hepatomegaly and one showed osteochondritis. The tests RPR, TPHA, and FTA-ABS-19-sIgM were positive. The RPR titers varied from 1:64 to 1:256 and the babies were diagnosed with congenital syphilis. They were successfully treated with penicillin. CONCLUSIONS: Successful therapy for syphilis during pregnancy demands maternal care as well as prevention or cure of congenital infection. The failure of azithromycin in preventing congenital syphilis in our report suggests that azithromycin should not be recommended as an alternative in treating syphilitic pregnant women or fetal syphilis.
Assuntos
Transmissão Vertical de Doenças Infecciosas/prevenção & controle , Complicações Infecciosas na Gravidez/epidemiologia , Complicações Infecciosas na Gravidez/prevenção & controle , Sífilis/epidemiologia , Sífilis/prevenção & controle , Administração Oral , Adulto , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Azitromicina/administração & dosagem , Azitromicina/uso terapêutico , China/epidemiologia , Esquema de Medicação , Feminino , Humanos , Recém-Nascido , Infusões Intravenosas , Masculino , Gravidez , Complicações Infecciosas na Gravidez/sangue , Complicações Infecciosas na Gravidez/etiologia , Cuidado Pré-Natal , Sífilis/sangue , Sífilis/etiologia , Sífilis/transmissão , Sorodiagnóstico da Sífilis , Sífilis Congênita/sangue , Sífilis Congênita/epidemiologia , Sífilis Congênita/etiologia , Sífilis Congênita/prevenção & controleRESUMO
OBJECTIVES: To evaluate the efficacy of ceftriaxone in pregnant women who were diagnosed with early syphilis. STUDY: Eleven women with a history of penicillin allergy, positive skin test, but prior history of safe usage of cephalosporins were included. Ceftriaxone (250 mg) was given intramuscularly once daily for 7 and 10 days to patients with primary and secondary syphilis, respectively. A second course of therapy was provided at 28 weeks' gestation. The rapid plasma reagin test (RPR) was measured before and after therapy. The blood of neonates was also tested at delivery and during the follow-up period. RESULTS: The serum RPR titers of 11 mothers decreased fourfold, 3 months after treatment. Ten patients developed negative RPR results. The serum RPR was negative at delivery or 6 months after delivery in all neonates. CONCLUSIONS: Ceftriaxone may be considered as an alternative for treatment of early syphilis in pregnancy.