Detalhe da pesquisa
1.
Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system.
Proc Natl Acad Sci U S A
; 118(40)2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34593635
2.
Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J Biol Chem
; 292(14): 5724-5735, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28196869
3.
Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.
J Biol Chem
; 291(5): 2271-87, 2016 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627834
4.
A novel mechanism of latency in matrix metalloproteinases.
J Biol Chem
; 290(8): 4728-4740, 2015 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25555916
5.
Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol Cell
; 31(4): 598-606, 2008 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722183
6.
Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.
J Biol Chem
; 289(46): 32291-32302, 2014 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25266723
7.
Structural basis for the sheddase function of human meprin ß metalloproteinase at the plasma membrane.
Proc Natl Acad Sci U S A
; 109(40): 16131-6, 2012 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22988105
8.
Structure-function studies of the staphylococcal methicillin resistance antirepressor MecR2.
J Biol Chem
; 288(29): 21267-21278, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23733184
9.
Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases.
J Biol Chem
; 288(20): 14287-14296, 2013 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23558682
10.
Structural and functional insights into the C-terminal signal domain of the Bacteroidetes type-IX secretion system.
Open Biol
; 14(6): 230448, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38862016
11.
Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 69(Pt 5): 472-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23695557
12.
Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.
Dalton Trans
; 52(12): 3610-3622, 2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857690
13.
A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
Chem Sci
; 14(4): 869-888, 2023 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36755705
14.
Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HmrA is a zinc-dependent endopeptidase.
J Biol Chem
; 286(29): 25697-709, 2011 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21622555
15.
The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases.
Mol Microbiol
; 79(1): 119-32, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21166898
16.
The crystal structure of human α2-macroglobulin reveals a unique molecular cage.
Angew Chem Int Ed Engl
; 51(14): 3340-4, 2012 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22290936
17.
Zymogenic latency in an â¼250-million-year-old astacin metallopeptidase.
Acta Crystallogr D Struct Biol
; 78(Pt 11): 1347-1357, 2022 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36322418
18.
An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin.
Comput Struct Biotechnol J
; 20: 534-544, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35465156
19.
Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis.
Protein Sci
; 31(10): e4427, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36173175
20.
De novo design of immunoglobulin-like domains.
Nat Commun
; 13(1): 5661, 2022 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36192397