Detalhe da pesquisa
1.
Metabolism-driven in vitro/in vivo disconnect of an oral ERÉ VHL-PROTAC.
Commun Biol
; 7(1): 563, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740899
2.
Identification and design of a novel series of MGAT2 inhibitors.
Bioorg Med Chem Lett
; 23(9): 2721-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541669
3.
Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.
Bioorg Med Chem Lett
; 22(12): 3873-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22608962
4.
Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition.
Mol Cancer Ther
; 20(6): 1080-1091, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785652
5.
PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity.
J Immunother Cancer
; 6(1): 158, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587236
6.
Modeling and design of challenge tests: Inflammatory and metabolic biomarker study examples.
Eur J Pharm Sci
; 67: 144-159, 2015 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25435491
7.
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.
J Med Chem
; 57(3): 970-86, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24422550
8.
11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors still improve metabolic phenotype in male 11ß-HSD1 knockout mice suggesting off-target mechanisms.
Endocrinology
; 154(12): 4580-93, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169553
9.
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.
J Med Chem
; 55(23): 10652-61, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153367
10.
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
J Med Chem
; 55(14): 6363-74, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742641