Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Functional identification of a neurocircuit regulating blood glucose.

Meek, Thomas H; Nelson, Jarrell T; Matsen, Miles E; Dorfman, Mauricio D; Guyenet, Stephan J; Damian, Vincent; Allison, Margaret B; Scarlett, Jarrad M; Nguyen, Hong T; Thaler, Joshua P; Olson, David P; Myers, Martin G; Schwartz, Michael W; Morton, Gregory J.

Proc Natl Acad Sci U S A ; 113(14): E2073-82, 2016 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-27001850

2.

Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.

Guyenet, Stephan J; Mookerjee, Shona S; Lin, Amy; Custer, Sara K; Chen, Sylvia F; Sopher, Bryce L; La Spada, Albert R; Ellerby, Lisa M.

Hum Mol Genet ; 24(14): 3908-17, 2015 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-25859008

3.

Overestimated Impact of Lower-Carbohydrate Diets on Total Energy Expenditure.

Guyenet, Stephan J; Hall, Kevin D.

J Nutr ; 151(8): 2496-2497, 2021 08 07.

Artigo em Inglês | MEDLINE | ID: mdl-34363484

4.

Obesity: Appetite hormone weighs in.

Guyenet, Stephan J.

Nature ; 493(7433): 480, 2013 Jan 24.

Artigo em Inglês | MEDLINE | ID: mdl-23344350

5.

In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.

Matsen, Miles E; Thaler, Joshua P; Wisse, Brent E; Guyenet, Stephan J; Meek, Thomas H; Ogimoto, Kayoko; Cubelo, Alex; Fischer, Jonathan D; Kaiyala, Karl J; Schwartz, Michael W; Morton, Gregory J.

Am J Physiol Endocrinol Metab ; 304(7): E734-46, 2013 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-23384771

6.

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.

Mookerjee, Shona; Papanikolaou, Theodora; Guyenet, Stephan J; Sampath, Vanitha; Lin, Amy; Vitelli, Cathy; DeGiacomo, Francesco; Sopher, Bryce L; Chen, Sylvia F; La Spada, Albert R; Ellerby, Lisa M.

J Neurosci ; 29(48): 15134-44, 2009 Dec 02.

Artigo em Inglês | MEDLINE | ID: mdl-19955365

7.

Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

Custer, Sara K; Garden, Gwenn A; Gill, Nishi; Rueb, Udo; Libby, Randell T; Schultz, Christian; Guyenet, Stephan J; Deller, Thomas; Westrum, Lesnick E; Sopher, Bryce L; La Spada, Albert R.

Nat Neurosci ; 9(10): 1302-11, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16936724

8.

Impact of Whole, Fresh Fruit Consumption on Energy Intake and Adiposity: A Systematic Review.

Guyenet, Stephan J.

Front Nutr ; 6: 66, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31139631

9.

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman, Mauricio D; Krull, Jordan E; Scarlett, Jarrad M; Guyenet, Stephan J; Sajan, Mini P; Damian, Vincent; Nguyen, Hong T; Leitges, Michael; Morton, Gregory J; Farese, Robert V; Schwartz, Michael W; Thaler, Joshua P.

Diabetes ; 66(4): 920-934, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28073831

10.

Increase in adipose tissue linoleic acid of US adults in the last half century.

Guyenet, Stephan J; Carlson, Susan E.

Adv Nutr ; 6(6): 660-4, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26567191

11.

Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans.

Schur, Ellen A; Melhorn, Susan J; Oh, Seok-Kyun; Lacy, J Matthew; Berkseth, Kathryn E; Guyenet, Stephan J; Sonnen, Joshua A; Tyagi, Vidhi; Rosalynn, Mary; De Leon, B; Webb, Mary F; Gonsalves, Zenobia T; Fligner, Corinne L; Schwartz, Michael W; Maravilla, Kenneth R.

Obesity (Silver Spring) ; 23(11): 2142-8, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26530930

12.

Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study.

Berkseth, Kathryn E; Guyenet, Stephan J; Melhorn, Susan J; Lee, Donghoon; Thaler, Joshua P; Schur, Ellen A; Schwartz, Michael W.

Endocrinology ; 155(8): 2858-67, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24914942

13.

The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction.

McCormick, Mark A; Mason, Amanda G; Guyenet, Stephan J; Dang, Weiwei; Garza, Renee M; Ting, Marc K; Moller, Rick M; Berger, Shelley L; Kaeberlein, Matt; Pillus, Lorraine; La Spada, Albert R; Kennedy, Brian K.

Cell Rep ; 8(2): 477-86, 2014 Jul 24.

Artigo em Inglês | MEDLINE | ID: mdl-25043177

14.

The Carbohydrate-Insulin Model of Obesity Is Difficult to Reconcile With Current Evidence.

Hall, Kevin D; Guyenet, Stephan J; Leibel, Rudolph L.

JAMA Intern Med ; 178(8): 1103-1105, 2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-29971320

15.

Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food.

Guyenet, Stephan J; Matsen, Miles E; Morton, Gregory J; Kaiyala, Karl J; Schwartz, Michael W.

Mol Metab ; 2(2): 116-22, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24199157

16.

High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes.

Guyenet, Stephan J; Nguyen, Hong T; Hwang, Bang H; Schwartz, Michael W; Baskin, Denis G; Thaler, Joshua P.

Brain Res ; 1512: 97-105, 2013 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-23548599

17.

Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia.

Meek, Thomas H; Matsen, Miles E; Dorfman, Mauricio D; Guyenet, Stephan J; Damian, Vincent; Nguyen, Hong T; Taborsky, Gerald J; Morton, Gregory J.

Endocrinology ; 154(9): 3067-76, 2013 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-23782941

18.

BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production.

Meek, Thomas H; Wisse, Brent E; Thaler, Joshua P; Guyenet, Stephan J; Matsen, Miles E; Fischer, Jonathan D; Taborsky, Gerald J; Schwartz, Michael W; Morton, Gregory J.

Diabetes ; 62(5): 1512-8, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23274899

19.

Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity.

Guyenet, Stephan J; Schwartz, Michael W.

J Clin Endocrinol Metab ; 97(3): 745-55, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22238401

20.

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, Joshua P; Yi, Chun-Xia; Schur, Ellen A; Guyenet, Stephan J; Hwang, Bang H; Dietrich, Marcelo O; Zhao, Xiaolin; Sarruf, David A; Izgur, Vitaly; Maravilla, Kenneth R; Nguyen, Hong T; Fischer, Jonathan D; Matsen, Miles E; Wisse, Brent E; Morton, Gregory J; Horvath, Tamas L; Baskin, Denis G; Tschöp, Matthias H; Schwartz, Michael W.

J Clin Invest ; 122(1): 153-62, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22201683

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