Detalhe da pesquisa
1.
A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors.
PLoS Biol
; 19(5): e3001263, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34033645
2.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695224
3.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
4.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.
Bioorg Med Chem Lett
; 27(16): 3897-3904, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687206
5.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Bioorg Med Chem Lett
; 27(15): 3219-3225, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28655422
6.
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ.
EBioMedicine
; 103: 105124, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38701619
7.
New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens.
FEBS Open Bio
; 12(10): 1896-1908, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36062323
8.
Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.
Mol Oncol
; 16(1): 148-165, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34392603
9.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
10.
High content drug screening for Fanconi anemia therapeutics.
Orphanet J Rare Dis
; 15(1): 170, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32605631
11.
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.
Cell Rep
; 32(2): 107897, 2020 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32668248
12.
A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.
Cell Chem Biol
; 26(2): 235-243.e5, 2019 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30527999
13.
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Cancer Res
; 77(4): 937-948, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899380
14.
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
J Med Chem
; 60(5): 2148-2154, 2017 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28145708
15.
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Nat Commun
; 8(1): 1541, 2017 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29142246
16.
Case-specific potentiation of glioblastoma drugs by pterostilbene.
Oncotarget
; 7(45): 73200-73215, 2016 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689322
17.
Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions.
Neuro Oncol
; 15(11): 1469-78, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24101737