Detalhe da pesquisa
1.
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Proc Natl Acad Sci U S A
; 119(27): e2200260119, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771941
2.
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
Cancer Discov
; 2024 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588399
3.
Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Nat Chem Biol
; 7(1): 22-4, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21113170
4.
First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma.
Cancer Discov
; 9(12): 1696-1707, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31575541
5.
Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.
Mol Cell Biol
; 25(3): 979-87, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15657426
6.
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.
Mol Cell Biol
; 22(3): 901-15, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11784865
7.
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Cancer Discov
; 5(4): 424-37, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25776529
8.
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
J Med Chem
; 52(14): 4400-18, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19522463
9.
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
J Med Chem
; 51(21): 6646-9, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842035
10.
Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein.
J Biol Chem
; 277(21): 18677-86, 2002 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-11904289