RESUMO
Numerical methods are used to simulate the response of field emission to incident pulses of optical radiation, with the objective of determining the criteria to reduce the time for response of the emitted current to the radiation. The results of these simulations suggest that a sub-femtosecond response may be achieved by increasing the power flux density of the radiation, and decreasing the applied static field. An intrinsic delay in the response is shown to correspond to the semiclassical time for traversal of the barrier by quantum tunneling.
RESUMO
Relaxation oscillations occur when a capacitor is inserted in series with a field emission tube, a DC high-voltage power supply, and a ballast resistor. The waveform of these oscillations is highly reproducible with a dominant frequency of 200 MHz and a decay time of 20 ns. The peak current as high as 320 mA has been observed although the tungsten emitter is only rated for 10 microA. We have shown that these oscillations are due to a displacement current, charging of the anode-tip capacitance, and are not of a field emission origin. We conclude that the effects of displacement current should be considered in measurements of field emission with microsecond pulses, where high-current densities can be observed.
RESUMO
A series of experiments has been carried out in order to characterize a miniannular phased array applicator prior to possible clinical implementation. The energy deposition patterns over the frequency range of 100 to 200 MHz were determined in several human limb models of different complexities by measuring the electric field strength patterns. The point of maximum energy deposition within a homogeneous, muscle-equivalent cylindrical phantom positioned coaxially within the MAPA was found to be at the center of the applicator. The energy deposition patterns seem to be more uniform at the lower frequencies. Inclusion of a cylindrical bone-equivalent phantom positioned coaxially with this muscle-equivalent phantom does not seem to significantly alter the energy deposition patterns in the muscle-equivalent region. For more realistically shaped, homogeneous muscle-equivalent limb models, the resulting energy deposition patterns appear to be confined mostly to the intended treatment region. However, the point of maximum energy deposition was not at the middle of the applicator as with the cylindrical model, but shifted towards a smaller cross-sectional region. This shift in location of the point of maximum energy deposition varies with the location of the MAPA on the limb. A secondary region of high-field strength was also observed at the ankle for a MAPA centered about the knee. In this study, the energy deposition patterns appear to be significantly dependent on the shape of the model. Therefore, this factor must be taken into consideration for the proper prediction and control of the heating patterns resulting from the use of this type of applicator for clinical hyperthermia treatment.
Assuntos
Hipertermia Induzida/instrumentação , Modelos Anatômicos , Humanos , Hipertermia Induzida/métodos , MatemáticaRESUMO
The energy deposition pattern within an isolated human leg heated with a mini-annular phased array (MAPA) hyperthermia applicator has been determined. The non-tumor-bearing lower portion of a human leg amputated at the hip due to the presence of a large tumor in the thigh was "fixed" in a 50% ethanol in 0.9% saline solution. Subsequent to this fixation process, the leg was rehydrated in 0.9% saline and heated four times using a MAPA operating at 122 MHz. Specific absorption rates and electric field strengths were calculated from the rates of change of temperature with time measured at 143 different anatomical locations within the leg. When the leg was coaxial with the MAPA and the MAPA was axially positioned midway between the knee and the ankle, the points of maximum heating were skewed away from the center of the MAPA, towards the ankle of the leg and along the central axis of the MAPA. Significant temperature rise was measured inside the bone and the fat as well as inside the muscle of the leg. Bone heating was reduced when the leg was shifted away from the MAPA axis.
Assuntos
Hipertermia Induzida/instrumentação , Perna (Membro) , Amputação Cirúrgica , Humanos , Hipertermia Induzida/métodos , TermodinâmicaRESUMO
Minimally perturbing, resistive, nonferrous probes were developed for noninvasively measuring hazardous currents induced in the human body by electromagnetic fields at 1 to 200 MHz. Each probe has a resistive toroidal coil that is placed around the leg or other body member. An electrostatic shield is required to limit capacitive coupling. A new shielded test fixture provides TEM fields for calibration with a VSWR less than 1.1 from 1 to 200 MHz. A man-sized phantom was exposed to the near-field of a vertical monopole antenna at 29.9 MHz, and the value of the current measured in the leg with our probe is in reasonable agreement with measured heating. Analyses and experiments show that commercial ferrous current probes modify the circuit in which they are used, changing the current being measured. Less change is caused by our nonferrous current probes.
Assuntos
Campos Eletromagnéticos , Monitoramento de Radiação/instrumentação , Viés , Calibragem , Impedância Elétrica , Eletrodos , Campos Eletromagnéticos/efeitos adversos , Desenho de Equipamento , Humanos , Teste de Materiais , Reprodutibilidade dos TestesRESUMO
A method to simulate photon-assisted tunneling is developed, and applied to model laser-assisted field emission from metals. Our simulations show that most of the exchange of quanta between the electrons and the radiation occurs within the emitting metal tip. In typical experiments (lambda = 670 nm with tungsten metal) the depth of penetration for the radiation is four times the mean free path for electrons at the Fermi level, so it is necessary to allow for scattering. We use a Floquet expansion with the time-dependent Schrödinger equation to allow for the exchange of quanta between the electrons and the radiation field. Multiparticle effects are modeled with the density functional theory within the local density approximation for the Kohn-Sham exchange and correlation, and the Fokker-Planck formulation is used to determine the effects of scattering on the energy distribution of the electrons.
RESUMO
Field emission of electrons from a variety of metallic, carbon fiber and composite metal-insulator micropoint cathodes was employed in this study. Tungsten, carbon fiber and ZrC tips, were studied using a field emission microscope. These cathodes were characterized and the current-voltage (I-V) characteristics were determined. A variety of surface treatment procedures were carried out to increase the stability of emission. These electron sources were mounted in sealed prototype field emission tubes, while others were tested under medium, high and UHV conditions. The emission current switch-on phenomenon was found with all non-metallic cathodes. The emitters were then subjected to a square wave-modulated, maximally focused laser diode beam (lambda = 658 nm, 30mW). The beam impedance (approximately 1 Gohms) and the anode capacitance (approximately 10 pF) act as a low-pass filter.
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Two types of self-sustained enhancement in field emission by carbon fibers are described. In the first, the field is increased until the emission current switches from zero to between 1 and 10 microA. Next the field is reduced, but not so far that the current would drop. Then the current remains for several hours to several days, with transient increases from the 10 microA to between 14 and 22 microA. It is believed that the transients are caused by the activation of new microtips on the fiber surface. These effects were noted when the carbon fiber tip was mounted in a closed glass vacuum bulb pumped by barium getters, and also in a vacuum system using the combination of a molecular drag pump and ion pumps. The second type of enhancement occurs under ultrahigh vacuum conditions, during in situ thermal treatment of the carbon fiber tip while the emission current is about 2.5 microA. A specially built cathode assembly enables heating the tip to approximately 725 degrees C. After continuous heating at 570 degrees C for 20 to 35 h, the current suddenly increases to between 13 and 25 microA. This enhancement is reversible if the emitted current is kept at the newly increased value for at least 30 min. The current-voltage characteristics at several temperatures were recorded and analyzed. Similar field-forming phenomena were previously observed with Molybdenum and ZnO-W tips.
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The results of block model calculations for multiple discretizations of a dielectric sphere and circular cylinder suggest that it is essential that the cells must be arranged for a best-fit of the body being modeled, the matrix elements must be reasonably accurate, and the cells must be small enough so that the pulse-function basis approximation is not blatantly unreasonable. When these criteria are approximately satisfied the remaining errors appear to be mainly due to imperfect representation of the shape of the object being modeled. It appears that the accuracy can be improved by using discretizations having cells of reduced size near the surface of the object. Geometric factors are defined which allow testing the potential accuracy of a solution without dimensioning or inverting a large matrix. Several unique procedures for discretization are also described that have the potential of partially mitigating the errors due to inaccurate representation of the shape of a scatterer.
Assuntos
Hipertermia Induzida/métodos , Modelos Anatômicos , Neoplasias/terapia , Humanos , Músculos/fisiologia , SoluçõesAssuntos
Regulação da Temperatura Corporal , Hipertermia Induzida , Modelos Biológicos , Abdome , Engenharia Biomédica , Extremidades , Humanos , Pulmão/fisiologia , Modelos Teóricos , Músculos/irrigação sanguínea , Neoplasias/terapia , Ondas de Rádio , Fluxo Sanguíneo Regional , Pele/irrigação sanguíneaRESUMO
The electromagnetic energy deposited in a semi-infinite slab model consisting of skin, fat, and muscle layers is calculated for both plane-wave and near-field exposures. The plane-wave spectrum (PWS) approach is used to calculate the energy deposited in the model by fields present due to leakage from equipment using electromagnetic energy. This analysis applies to near-field exposures where coupling of the target to the leakage source can be neglected. Calculations were made for 2,450 MHz, at which frequency the layered slab adequately models flat regions of the human body. Resonant absorption due to layering is examined as a function of the skin and fat thicknesses for plane-wave exposure and as a function of the physical extent of the near-field distribution. Calculations show that for fields that are nearly constant over at least a free-space wavelength, the energy deposition (for skin, fat, and muscle combination that gives resonant absorption) is equal to or less than that resulting from plane-wave exposure, but is appreciably greater than that obtained for a homogeneous muscle slab model.
Assuntos
Campos Eletromagnéticos , Fenômenos Eletromagnéticos , Transferência de Energia , Absorção , Tecido Adiposo/efeitos da radiação , Humanos , Modelos Teóricos , Músculos/efeitos da radiação , Pele/efeitos da radiaçãoRESUMO
A solid-state computer-controlled system has been used to make swept-frequency measurements of absorption of biological specimens from 26.5 to 90.0 GHz. A wide range of samples was used, including solutions of DNA and RNA, and suspensions of BHK-21/C13 cells, Candida albicans, C krusei, and Escherichia coli. Sharp spectra reported by other workers were not observed. The strong absorbance of water (10--30 dB/mm) caused the absorbance of all aqueous preparations that we examined to have a water-like dependence on frequency. Reduction of incident power (to below 1.0 microW), elimination of modulation, and control of temperature to assure cell viability were not found to significantly alter the water-dominated absorbance. Frozen samples of BHK-21/C13 cells tested at dry ice and liquid nitrogen temperatures were found to have average insertion loss reduced to 0.2 dB/cm but still showed no reproducible peaks that could be attributed to absorption spectra. It is concluded that the special resonances reported by others are likely to be in error.
Assuntos
Micro-Ondas , Absorção , Animais , Candida/efeitos dos fármacos , Células Cultivadas , Cricetinae , DNA/efeitos da radiação , Escherichia coli/efeitos da radiação , Rim , Mesocricetus , RNA/efeitos da radiação , Doses de RadiaçãoRESUMO
The exposure of humans to electromagnetic near fields has not been sufficiently emphasized by researcher. We have used the plane-wave-spectrum approach to evaluate the electromagnetic field and determine the energy deposited in a lossy, homogeneous, semi-infinite slab placed in the near field of a source leaking radiation. Values of the fields and absorbed energy in the target are obtained by vector summation of the contributions of all the plane waves into which the prescribed field is decomposed. Use of a fast Fourier transform algorithm contributes to the high efficiency of the computations. The numerical results show that, for field distributions that are nearly constant over a physical extent of at least a free-space wavelength, the energy coupled into the target is approximately equal to the resulting from plane-wave exposed.