Detalhe da pesquisa
1.
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.
J Am Chem Soc
; 145(14): 8176-8188, 2023 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36976643
2.
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.
Nucleic Acids Res
; 49(20): 11629-11642, 2021 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34086966
3.
Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.
Org Biomol Chem
; 14(2): 631-638, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26541578
4.
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.
J Biol Chem
; 289(17): 12177-12188, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24634223
5.
A scintillation proximity assay for histone demethylases.
Anal Biochem
; 463: 54-60, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25010373
6.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem J
; 449(1): 151-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989411
7.
Kinetic characterization of human mRNA guanine-N7 methyltransferase.
Sci Rep
; 14(1): 4509, 2024 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38402266
8.
SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.
Biochim Biophys Acta Gen Subj
; 1867(4): 130319, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36764586
9.
Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
J Med Chem
; 66(1): 934-950, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36581322
10.
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase.
ACS Chem Biol
; 18(4): 734-745, 2023 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37082867
11.
Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
J Am Chem Soc
; 134(43): 18004-14, 2012 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043551
12.
Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors.
ACS Infect Dis
; 8(8): 1533-1542, 2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35822715
13.
Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.
Protein Sci
; 31(9): e4395, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040262
14.
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19.
SLAS Discov
; 26(5): 620-627, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33423577
15.
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
SLAS Discov
; 26(6): 757-765, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33874769
16.
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors.
SLAS Discov
; 26(9): 1200-1211, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34192965
17.
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors.
bioRxiv
; 2021 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619486
18.
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.
Elife
; 82019 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31657716
19.
Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.
SLAS Discov
; 23(9): 930-940, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29562800
20.
Targeting human SET1/MLL family of proteins.
Protein Sci
; 26(4): 662-676, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28160335