Detalhe da pesquisa
1.
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Nature
; 501(7466): 232-6, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934108
2.
Talin-dependent integrin activation is required for fibrin clot retraction by platelets.
Blood
; 117(5): 1719-22, 2011 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20971947
3.
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor.
Nat Med
; 28(10): 2171-2182, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36216931
4.
EndoBind detects endogenous protein-protein interactions in real time.
Commun Biol
; 4(1): 1085, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34526658
5.
Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J Med Chem
; 64(8): 4857-4869, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33821636
6.
Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.
J Biol Chem
; 284(52): 36700-36710, 2009 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19843520
7.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J Med Chem
; 63(5): 2013-2027, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31059256
8.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.
Cancer Res
; 78(6): 1537-1548, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343524
9.
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J Med Chem
; 60(12): 4869-4881, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28557458
10.
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.
Cancer Cell
; 26(3): 402-413, 2014 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155755
11.
Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.
Mol Biol Cell
; 21(4): 664-73, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20032303
12.
An experimentally derived database of candidate Ras-interacting proteins.
J Proteome Res
; 6(5): 1806-11, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17439166