Detalhe da pesquisa
1.
Structure of the Inhibited State of the Sec Translocon.
Mol Cell
; 79(3): 406-415.e7, 2020 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32692975
2.
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1ß, are linked to fibrin formation in Buruli ulcer lesions.
PLoS Pathog
; 18(1): e1010280, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35100311
3.
TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.
Nucleic Acids Res
; 49(6): 3242-3262, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33660774
4.
Murine Norovirus Infection Results in Anti-inflammatory Response Downstream of Amino Acid Depletion in Macrophages.
J Virol
; 95(20): e0113421, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34346771
5.
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
PLoS Pathog
; 16(1): e1008250, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31905230
6.
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state.
Biochem J
; 478(22): 4005-4024, 2021 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726690
7.
Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei.
Proc Natl Acad Sci U S A
; 116(33): 16561-16570, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358644
8.
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F.
Molecules
; 27(14)2022 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35889292
9.
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
J Am Chem Soc
; 141(21): 8450-8461, 2019 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31059257
10.
The role of genomic location and flanking 3'UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei.
Mol Microbiol
; 106(4): 614-634, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28906055
11.
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.
PLoS Pathog
; 11(7): e1005011, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26181660
12.
The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
PLoS Pathog
; 10(4): e1004061, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24699819
13.
An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.
J Biol Chem
; 288(40): 28466-76, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23946481
14.
Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.
Biochem Soc Trans
; 42(1): 177-83, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450648
15.
Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone.
Neurochem Res
; 39(6): 1068-78, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24078264
16.
Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme.
Mem Inst Oswaldo Cruz
; 109(3): 315-23, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24676659
17.
Evaluating 5-nitrofurans as trypanocidal agents.
Antimicrob Agents Chemother
; 57(4): 1638-47, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23335745
18.
Synthesis and anti-parasitic activity of a novel quinolinone-chalcone series.
Bioorg Med Chem Lett
; 23(23): 6436-41, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24119553
19.
Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
J Infect Dis
; 206(2): 220-8, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22551809
20.
Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection.
bioRxiv
; 2023 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36865118