1.
J Org Chem
; 78(11): 5160-71, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23692141
RESUMO
A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) analysis.