Highly Sensitive Fiber Crossbar Sensors Enabled by Second-Order Synergistic Effect of Air Capacitance and Equipotential Body.

Fiber crossbars, an emerging electronic device, have become the most promising basic unit for advanced smart textiles. The demand for highly sensitive fiber crossbar sensors (FCSs) in wearable electronics is increased. However, the unique structure of FCSs presents challenges in replicating existing sensitivity enhancement strategies. Aiming at the sensitivity of fiber crossbar sensors, a second-order synergistic strategy is proposed that combines air capacitance and equipotential bodies, resulting in a remarkable sensitivity enhancement of over 20 times for FCSs. This strategy offers a promising avenue for the design and fabrication of FCSs that do not depend on intricate microstructures. Furthermore, the integrative structure of core-sheath fibers ensures a robust interface, leading to a low hysteresis of only 2.33% and exceptional stability. The outstanding capacitive response performance of FCSs allows them to effectively capture weak signals such as pulses and sounds. This capability opens up possibilities for the application of FCSs in personalized health management, as demonstrated by wireless monitoring systems based on pulse signals.

Retrospective study about clinical severity and epidemiological analysis of the COVID-19 Omicron subvariant lineage-infected patients in Hohhot, China.

BACKGROUND: Fear of a global public health issue and fresh infection wave in the persistent COVID-19 pandemic has been enflamed by the appearance of the novel variant Omicron BF.7 lineage. Recently, it has been seeing the novel Omicron subtype BF.7 lineage has sprawled exponentially in Hohhot. More than anything, risk stratification is significant to ascertain patients infected with COVID-19 who the most need in-hospital or in-home management. The study intends to understand the clinical severity and epidemiological characteristics of COVID-19 Omicron subvariant BF.7. lineage via gathering and analyzing the cases with Omicron subvariant in Hohhot, Inner Mongolia. METHODS: Based upon this, we linked variant Omicron BF.7 individual-level information including sex, age, symptom, underlying conditions and vaccination record. Further, we divided the cases into various groups and assessed the severity of patients according to the symptoms of patients with COVID-19. Clinical indicators and data might help to predict disadvantage outcomes and progression among Omicron BF.7 patients. RESULTS: In this study, in patients with severe symptoms, some indicators from real world data such as white blood cells, AST, ALT and CRE in patients with Omicron BF.7 in severe symptoms were significantly higher than mild and asymptomatic patients, while some indicators were significantly lower. CONCLUSIONS: Above results suggested that the indicators were associated with ponderance of clinical symptoms. Our survey emphasized the value of timely investigations of clinical data obtained by systemic study to acquire detailed information.

Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing.

Bacterial cellulose (BC) hydrogels are promising medical biomaterials that have been widely used for tissue repair, wound healing and cartilage engineering. However, the high water content of BC hydrogels increases the difficulty of storage and transportation. Moreover, they will lose their original hydrogel structure after dehydration, which severely limits their practical applications. Introducing the bio-based polyelectrolytes is expected to solve this problem. Here, we modified BC and combined it with quaternized chitosan (QCS) via a chemical reaction to obtain a dehydrated dialdehyde bacterial cellulose/quaternized chitosan (DBC/QCS) hydrogel with repeated swelling behavior and good antibacterial properties. The hydrogel can recover the initial state on the macro scale with a swelling ratio over 1000 % and possesses excellent antimicrobial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with a killing rate of 80.8 % and 81.3 %, respectively. In addition, the hydrogel has excellent biocompatibility, which is conducive to the stretching of L929 cells. After 14 d of in vivo wound modeling in rats, it was found that the hydrogel loaded with pirfenidone (PFD) could promote collagen deposition and accelerate wound healing with scar prevention. This rehydratable hydrogel can be stored and transported under dry conditions, which is promising for practical applications.

Bacterial cellulose-based film with self-floating hierarchical porous structure for efficient solar-driven interfacial evaporation.

Interface solar water evaporation is a mean of rapidly evaporating water using solar energy. However, it is still a challenge to obtain solar evaporators with simple assembly, durability and high photothermal performance. Here, we demonstrated an effective post foaming strategy for treating nitrogen-doped reduced graphene oxide/bacterial cellulose film (F-NRGO@BC) prepared by a simple in situ culture method. The composite film contains hierarchical porous structure and bubbles on the film, achieving an integrated self-floating interface evaporator with excellent light absorption (96.5 %) and high toughness (200.18 kJ m-3). Porous structure and low enthalpy of F-NRGO@BC make a high evaporation rate of 1.68 kg m-2 h-1 and a low thermal conductivity of 0.644 W m-1 K-1 to ensure effective energy efficiency and heat insulation. This design of controlling surface morphology and internal structure provides a novel way for large-scale preparation and high-performance evaporator.

Highly Sensitive Fiber Pressure Sensors over a Wide Pressure Range Enabled by Resistive-Capacitive Hybrid Response.

Soft capacitive pressure sensors with high performance are becoming increasingly in demand in the emerging flexible wearable field. While capacitive fiber pressure sensors have achieved high sensitivity, their sensitivity range is limited to low-pressure levels. As fiber sensors typically require preloading and fixation, this narrow range of high sensitivity poses a challenge for practical applications. To overcome this limitation, the study proposes resistive-capacitive hybrid response fiber pressure sensors (HFPSs) with three-layer core-sheath structures. The trigger and sensitivity enhancement mechanisms of the hybrid response are determined through model analysis and experimental verification. By adjustment of the sensitivity enhancement range of the hybrid response, the sensitivity attenuation of HFPSs is alleviated significantly. The obtained results demonstrate that HFPSs have excellent characteristics such as fast response, low hysteresis, wide response frequency, small signal drift, and good durability. The hybrid response enhances the practical sensitivity of HFPSs for various applications. With enhanced sensitivity, HFPSs can effectively monitor pulse signals at preloads ranging from 0 to 22.7 kPa. This wide range of preloads improves the fault tolerance of pulse monitoring and expands the potential application scenarios of fiber pressure sensors.

Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing.

Skin wounds need an appropriate wound dressing to help prevent bacterial infection and accelerate wound closure. Bacterial cellulose (BC) with a three-dimensional (3D) network structure is an important commercial dressing. However, how to effectively load antibacterial agents and balance the antibacterial activity is a lingering issue. Herein, this study aims to develop a functional BC hydrogel containing silver-loaded zeolitic imidazolate framework-8 (ZIF-8) antibacterial agent. The tensile strength of the prepared biopolymer dressing is >1 MPa, the swelling property is over 3000 %, the temperature can reach 50 °C in 5 min with near-infrared (NIR) and the release of Ag+ and Zn2+ is stable. In vitro investigation shows that the hydrogel displays enhanced antibacterial activity, and the bacteria survival ratios are only 0.85 % and 0.39 % against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In vitro cell experiments present that BC/polydopamine/ZIF-8/Ag (BC/PDA/ZIF-8/Ag) shows satisfactory biocompatibility and promising angiogenic ability. In vivo study, the full-thickness skin defect on rats demonstrates remarkably wound healing ability and accelerated skin re-epithelialization. This work presents a competitive functional dressing with effective antibacterial properties and accelerative angiogenesis activities for wound repair.

Self-Stretchable Fiber Liquid Sensors Made with Bacterial Cellulose/Carbon Nanotubes for Smart Diapers.

Liquid sensors for detecting water and body fluids are crucial in daily water usage and health monitoring, but it is challenging to combine sensing performance with high tensile deformation and multifunctional applications. Here, a substrate-free, self-stretchable bacterial cellulose (BC)/carbon nanotube (CNT) helical fiber liquid sensor was prepared by the solution spinning and coiling process using BC as the water-sensitive matrix and CNTs as the active sensing materials. The BC/CNT (BCT) fiber sensor has a high stretch ratio of more than 1000% and a rapid response for a current change rate of 104% within 1 s, which is almost unaffected under washing and various stretching or knotting deformations. By combination of the BCT fiber, we can design smart diapers or water level detectors, which rapidly monitor the status of smart diapers or water level, and the monitoring result can be transferred on time through an alarm device or smartphone. In short, the scalable and continuous preparation of the self-stretchable BCT helical fiber will provide a capacious platform for the development of a wearable sensor applied in daily life (such as smart diapers, water level detection, etc.).

Toward continuous high-performance bacterial cellulose macrofibers by implementing grading-stretching in spinning.

At present, the orderly assembly of bio-cellulose nanofibers (CNFs) with excellent mechanical properties in a simple and continuous manner still remains a challenge. Here, we propose a strategy of combining a wet spinning process with a self-made grading-stretching device to realize the continuous preparation of high-performance bacterial cellulose (BC) macrofibers. The macrofiber obtained by one-stage stretching at the optimum stretching ratio of 40% achieves the Young's modulus of 19.8 GPa and tensile strength of 544.5 MPa. Under two-stage stretching, wide-angle X-ray (WXRD) diffraction analysis revealed that the second orientation of nanofibers shows a higher degree of orientation than that under one-stage stretching. The maximum Young's modulus and tensile strength of the macrofiber can reach 33.2 GPa and 659.8 MPa, respectively, which are higher than most CNFs macrofibers obtained by spinning and post-stretching. This research is expected to provide a significant reference for the industrial spinning of nanocellulose.

Anti-Fouling, Adhesive Polyzwitterionic Hydrogel Electrodes Toughened Using a Tannic Acid Nanoflower.

Conductive polyzwitterionic hydrogels with good adhesion properties show potential prospect in implantable electrodes and electronic devices. Adhesive property of polyzwitterionic hydrogels in humid environments can be improved by the introduction of catechol groups. However, common catechol modifiers can usually quench free radicals, resulting in a contradiction between long-term tissue adhesion and hydrogel toughness. By adding tannic acid (TA) to the dispersion of clay nanosheets and nanofibers, we designed TA-coated nanoflowers and nanofibers as the reinforcing phase to prepare polyzwitterionic hydrogels with adhesion properties. The hydrogel combines the mussel-like and zwitterionic co-adhesive mechanism to maintain long-term adhesion in underwater environments. In particular, the noncovalent cross-linking provided by the nanoflower structure effectively compensates for the defects caused by free-radical quenching so that the hydrogel obtained a high stretchability of over 2900% and a toughness of 1.16 J/m3. The hydrogel also has excellent anti-biofouling property and shows resistance to bacteria and cells. In addition, the hydrogel possesses a low modulus (<10 kPa) and ionic conductivity (0.25 S/m), making it an ideal material for the preparation of implantable electrodes.

Bacterial cellulose reinforced chitosan-based hydrogel with highly efficient self-healing and enhanced antibacterial activity for wound healing.

Biocompatible hydrogels with versatile functions are highly desired for demanding the complicated tissue issues, including irregular site and motional wound. Herein, a bio-based hydrogel with multifunctional properties is designed based on quaternized chitosan and dialdehyde bacterial cellulose. As a functional wound dressing, the hydrogel shows rapid self-healing performance and injectable behaviors due to dynamic Schiff-base interactions and presents superior antibacterial activity against E. coli (gram-negative) and S. aureus (gram-positive). The constructed 3D hydrogel also exhibits proper compressive property, desired water retention capacity. To be mentioned, the hydrogel could mimic the structure of natural extracellular matrix (ECM) in the presence of bacterial cellulose nanofibers. Thus, the biopolymer-based hydrogel shows good biocompatibility in terms of cell proliferation and cell spreading. The prepared chitosan-based hydrogel with self-healing, antibacterial, and low cost will become a promising biomaterial for wound healing.

Crack-Based Core-Sheath Fiber Strain Sensors with an Ultralow Detection Limit and an Ultrawide Working Range.

With the booming development of flexible wearable sensing devices, flexible stretchable strain sensors with crack structure and high sensitivity have been widely concerned. However, the narrow sensing range has been hindering the development of crack-based strain sensors. In addition, the existence of the crack structure may reduce the interface compatibility between the elastic matrix and the sensing material. Herein, to overcome these problems, integrated core-sheath fibers were prepared by coaxial wet spinning with partially added carbon nanotube sensing materials in thermoplastic polyurethane elastic materials. Due to the superior interface compatibility and the change in the conductive path during stretching, the fiber strain sensor exhibits excellent durability (5000 tensile cycles), high sensitivity (>104), large stretchability (500%), a low detection limit (0.01%), and a fast response time of ∼60 ms. Based on these outstanding strain sensing performances, the fiber sensor is demonstrated to detect subtle strain changes (e.g., pulse wave and swallowing) and large strain changes (e.g., finger joint and wrist movement) in real time. Moreover, the fabric sensor woven with the core-sheath fibers has an excellent performance in wrist bending angle detection, and the smart gloves based on the fabric sensors also show exceptional recognition ability as a wireless sign language translation device. This integrated strategy may provide prospective opportunities to develop highly sensitive strain sensors with durable deformation and a wide detection range.

AC Electric-Field Assistant Architecting Ordered Network of Ni@PS Microspheres in Epoxy Resin to Enhance Conductivity.

By using the low loading of the conductor filler to achieve high conductivity is a challenge associated with electrically conductive adhesion. In this study, we show an assembling of nickel-coated polystyrene (Ni@PS) microspheres into 3-dimensional network within the epoxy resin with the assistance of an electric field. The morphology evolution of the microspheres was observed with optical microscopy and scanning electron microscopy (SEM). The response speed of Ni@PS microsphere to the electric field were investigated by measuring the viscosity and shear stress variation of the suspension at a low shear rate with an electrorheological instrument. The SEM results revealed that the Ni@PS microspheres aligned into a pearl-alike structure. The AC impedance spectroscopy confirmed that the conductivity of this pearl-alike alignment was significantly enhanced when compared to the pristine one. The maximum enhancement in conductivity is achieved at 15 wt. % of Ni@PS microspheres with the aligned composites about 3 orders of magnitude as much as unaligned one, typically from ~10-5 S/m to ~10-2 S/m.

Tailoring CO2-Activated Ion Nanochannels Using Macrocyclic Pillararenes.

Gas-responsive nanochannels have great relevance for applications in many fields. Inspired by CO2-sensitive ion channels, herein we present an approach for designing solid-state nanochannels that allow controlled regulation of ion transport in response to alternate CO2/N2 stimuli. The pillar[5]arene (P5N) bearing diethylamine groups can convert into the water-soluble host P5C, containing cationic tertiary ammonium salt groups after absorbing CO2. Subsequently, the nanochannel walls are tailored using P5N-based host-guest chemistry. The ion transport rate of K+ in the P5N nanochannels under CO2 was 1.66 × 10-4 mol h-1 m-2, whereas that under N2 was 7.98 × 10-4 mol h-1 m-2. Notably, there was no significant change to the ion current after eight cycles, which may indicate the stability and repeatability of CO2-activated ion nanochannels. It is speculated that the difference in ion conductance resulted from the change in wettability and surface charge within the nanochannels in response to the gas stimuli. Achieving CO2-activated ion transport in solid-state nanochannels opens new avenues for biomimetic nanopore systems and advanced separation processes.