Detalhe da pesquisa
1.
Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFß pathway inhibition.
Toxicol Appl Pharmacol
; 438: 115905, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122773
2.
Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1.
Toxicol Pathol
; 44(2): 267-78, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26692561
3.
The vedotin antibody-drug conjugate payload drives platform-based nonclinical safety and pharmacokinetic profiles.
Mol Cancer Ther
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38692647
4.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol
; 266(1): 86-94, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142475
5.
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Bioorg Med Chem Lett
; 23(11): 3149-53, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23623490
6.
Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.
BMC Pharmacol
; 12: 2, 2012 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22475049
7.
Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.
Xenobiotica
; 42(5): 456-65, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22122353
8.
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species.
Toxicol Sci
; 186(2): 323-337, 2022 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35134999
9.
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
J Med Chem
; 62(4): 2140-2153, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30715878
10.
Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.
J Med Chem
; 60(10): 4458-4473, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445037
11.
Balancing Blood Sample Volume with 3Rs: Implementation and Best Practices for Small Molecule Toxicokinetic Assessments in Rats.
ILAR J
; 57(2): 157-165, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28053069
12.
Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers.
Clin Cancer Res
; 21(22): 5139-50, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26156394
13.
Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats.
Toxicol Sci
; 67(2): 329-40, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12011493
14.
iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicology
; 175(1-3): 83-90, 2002 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-12049838
15.
An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.
J Pharm Sci
; 102(10): 3816-29, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23878104
16.
DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
Regul Pept
; 186: 26-35, 2013 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23850796
17.
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
J Med Chem
; 56(11): 4764-85, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659214
18.
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J Med Chem
; 55(13): 6176-93, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22698084
19.
Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development.
Mol Pharmacol
; 69(5): 1534-41, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16443691
20.
Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity.
Toxicol Appl Pharmacol
; 179(3): 155-62, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11906245