Detalhe da pesquisa
1.
Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes.
J Virol
; 93(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381490
2.
The S230R Integrase Substitution Associated With Virus Load Rebound During Dolutegravir Monotherapy Confers Low-Level Resistance to Integrase Strand-Transfer Inhibitors.
J Infect Dis
; 218(5): 698-706, 2018 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29617824
3.
Antiviral Activity of Bictegravir and Cabotegravir against Integrase Inhibitor-Resistant SIVmac239 and HIV-1.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28923862
4.
Monotherapy with either dolutegravir or raltegravir fails to durably suppress HIV viraemia in humanized mice.
J Antimicrob Chemother
; 72(9): 2570-2573, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28637235
5.
Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors.
J Antimicrob Chemother
; 72(3): 727-734, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28069884
6.
Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.
Antimicrob Agents Chemother
; 60(1): 600-8, 2016 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26574011
7.
Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.
J Virol
; 89(23): 12002-13, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26378179
8.
Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase.
J Virol
; 89(6): 3163-75, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25552724
9.
The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir.
Antimicrob Agents Chemother
; 59(1): 310-6, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25348535
10.
Simian-tropic HIV as a model to study drug resistance against integrase inhibitors.
Antimicrob Agents Chemother
; 59(4): 1942-9, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583721
11.
The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.
J Antimicrob Chemother
; 70(3): 750-6, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25433008
12.
Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors.
J Virol
; 88(17): 9683-92, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24920794
13.
Insertion as a Resistance Mechanism Against Integrase Inhibitors in Several Retroviruses.
Clin Infect Dis
; 69(8): 1460-1461, 2019 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30753366
14.
Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.
J Antimicrob Chemother
; 69(10): 2733-40, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24917583
15.
Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase.
Antimicrob Agents Chemother
; 57(12): 6223-35, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24080645
16.
Where are we with injectables against HIV infection and what are the remaining challenges?
Expert Rev Anti Infect Ther
; 16(2): 143-152, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29347858
17.
Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout.
AIDS
; 32(13): 1773-1780, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894388
18.
Evaluation of Sofosbuvir (ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methyluridine) as an inhibitor of Dengue virus replication.
Sci Rep
; 7(1): 6345, 2017 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740124
19.
Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review.
Pathog Immun
; 1(1): 41-67, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-30993244
20.
Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor.
PLoS One
; 10(6): e0128310, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046987