Detalhe da pesquisa
1.
PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
Mol Cell
; 83(16): 2991-3009.e13, 2023 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37567175
2.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
3.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Nat Immunol
; 17(1): 104-12, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26551880
4.
Acyl chain selection couples the consumption and synthesis of phosphoinositides.
EMBO J
; 41(18): e110038, 2022 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771169
5.
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system.
J Cell Sci
; 136(6)2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825945
6.
Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.
Immunity
; 45(3): 685-700, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566939
7.
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.
Mol Cell
; 68(3): 566-580.e10, 2017 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29056325
8.
The Parkinson's disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3.
J Cell Sci
; 132(20)2019 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31540955
9.
cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.
J Immunol
; 198(3): 1285-1296, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28039302
10.
Structure of lipid kinase p110ß/p85ß elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Mol Cell
; 41(5): 567-78, 2011 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21362552
11.
In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.
Proc Natl Acad Sci U S A
; 113(38): 10571-6, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27601656
12.
Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.
EMBO J
; 33(19): 2188-200, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25180230
13.
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Proc Natl Acad Sci U S A
; 111(1): 155-60, 2014 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24367090
14.
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
J Cell Sci
; 127(Pt 11): 2589-600, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24659802
15.
Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.
Biochem Soc Trans
; 44(1): 307-14, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26862220
16.
Two distinct functions for PI3-kinases in macropinocytosis.
J Cell Sci
; 126(Pt 18): 4296-307, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23843627
17.
Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.
J Immunol
; 190(1): 381-91, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23180820
18.
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.
Nat Methods
; 8(3): 267-72, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21278744
19.
3D time series analysis of cell shape using Laplacian approaches.
BMC Bioinformatics
; 14: 296, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24090312
20.
The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
Blood
; 118(4): 1087-98, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21490342