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Int J Mol Sci ; 25(13)2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-39000103

RESUMO

The number of people diagnosed with type 2 diabetes is on the increase worldwide. Of growing concern, the prevalence of type 2 diabetes in children and youths is increasing rapidly and mirrors the increasing burden of childhood obesity. There are many risk factors associated with the condition; some are due to lifestyle, but many are beyond our control, such as genetics. There is an urgent need to develop better therapeutics for the prevention and management of this complex condition since current medications often cause unwanted side effects, and poorly managed diabetes can result in the onset of related comorbidities. Naturally derived compounds have gained momentum for preventing and managing several complex conditions, including type 2 diabetes. Here, we provide an update on the benefits and limitations of fenugreek and its components as a therapeutic for type 2 diabetes, including its bioavailability and interaction with the microbiome.


Assuntos
Diabetes Mellitus Tipo 2 , Extratos Vegetais , Trigonella , Diabetes Mellitus Tipo 2/tratamento farmacológico , Humanos , Trigonella/química , Extratos Vegetais/uso terapêutico , Extratos Vegetais/farmacologia , Hipoglicemiantes/uso terapêutico , Hipoglicemiantes/farmacologia , Animais , Microbioma Gastrointestinal/efeitos dos fármacos
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