Detalhe da pesquisa
1.
Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers.
Molecules
; 28(11)2023 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298933
2.
Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
Molecules
; 27(3)2022 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164077
3.
Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Molecules
; 25(21)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105798
4.
Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors.
Molecules
; 24(8)2019 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010230
5.
Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors.
Molecules
; 24(14)2019 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31295864
6.
Chemical Space Mimicry for Drug Discovery.
J Chem Inf Model
; 57(4): 875-882, 2017 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28257191
7.
Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.
Chem Res Toxicol
; 29(8): 1310-24, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27380897
8.
Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers.
Adv Exp Med Biol
; 899: 269-90, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27325273
9.
Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.
Org Biomol Chem
; 12(21): 3386-92, 2014 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24737463
10.
Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents.
Bioorg Med Chem
; 22(2): 711-20, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24387866
11.
Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.
Bioorg Med Chem
; 22(7): 2123-32, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24650701
12.
Hypoxia-directed drug strategies to target the tumor microenvironment.
Adv Exp Med Biol
; 772: 111-45, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24272357
13.
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
Mol Cancer
; 12: 58, 2013 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23758947
14.
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.
RSC Med Chem
; 14(7): 1309-1330, 2023 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37484567
15.
Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro.
J Gene Med
; 14(1): 62-74, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147660
16.
Radiosensitisation of SCCVII tumours and normal tissues in mice by the DNA-dependent protein kinase inhibitor AZD7648.
Radiother Oncol
; 166: 162-170, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34861268
17.
SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells.
Bioorg Med Chem
; 19(11): 3347-56, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21561782
18.
Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
J Am Chem Soc
; 132(8): 2591-9, 2010 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20141134
19.
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer.
Cancers (Basel)
; 12(12)2020 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33322840
20.
Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.
ACS Pharmacol Transl Sci
; 3(2): 305-320, 2020 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32296770