The Dangers of Cortical Brain Maps.

The parcellation of the primate cerebral cortex into numbered regions, based on cytoarchitecture, has greatly helped neuroscientists in our quest to understand how the brain implements cognition. Nonetheless, these maps provide an unnecessarily constraining view of how we should do functional neuroanatomy. It is time to think more broadly. Doing so will help advance the goal of incorporating ideas about emergentist organization and interactional complexity into neuroscience.

Multicentric tracking of multiple agents by anterior cingulate cortex during pursuit and evasion.

Successful pursuit and evasion require rapid and precise coordination of navigation with adaptive motor control. We hypothesize that the dorsal anterior cingulate cortex (dACC), which communicates bidirectionally with both the hippocampal complex and premotor/motor areas, would serve a mapping role in this process. We recorded responses of dACC ensembles in two macaques performing a joystick-controlled continuous pursuit/evasion task. We find that dACC carries two sets of signals, (1) world-centric variables that together form a representation of the position and velocity of all relevant agents (self, prey, and predator) in the virtual world, and (2) avatar-centric variables, i.e. self-prey distance and angle. Both sets of variables are multiplexed within an overlapping set of neurons. Our results suggest that dACC may contribute to pursuit and evasion by computing and continuously updating a multicentric representation of the unfolding task state, and support the hypothesis that it plays a high-level abstract role in the control of behavior.

Continuous decisions.

Humans and other animals evolved to make decisions that extend over time with continuous and ever-changing options. Nonetheless, the academic study of decision-making is mostly limited to the simple case of choice between two options. Here, we advocate that the study of choice should expand to include continuous decisions. Continuous decisions, by our definition, involve a continuum of possible responses and take place over an extended period of time during which the response is continuously subject to modification. In most continuous decisions, the range of options can fluctuate and is affected by recent responses, making consideration of reciprocal feedback between choices and the environment essential. The study of continuous decisions raises new questions, such as how abstract processes of valuation and comparison are co-implemented with action planning and execution, how we simulate the large number of possible futures our choices lead to, and how our brains employ hierarchical structure to make choices more efficiently. While microeconomic theory has proven invaluable for discrete decisions, we propose that engineering control theory may serve as a better foundation for continuous ones. And while the concept of value has proven foundational for discrete decisions, goal states and policies may prove more useful for continuous ones. This article is part of the theme issue 'Existence and prevalence of economic behaviours among non-human primates'.

The neural basis of predictive pursuit.

It remains unclear whether and, if so, how nonhuman animals make on-the-fly predictions during pursuit. Here we used a novel laboratory pursuit task that incentivizes the prediction of future prey positions. We trained three macaques to perform a joystick-controlled pursuit task in which prey follow intelligent escape algorithms. Subjects aimed toward the likely future positions of the prey, which indicated that they generate internal predictions and use these to guide behavior. We then developed a generative model that explains real-time pursuit trajectories and showed that our subjects use prey position, velocity and acceleration to make predictions. We identified neurons in the dorsal anterior cingulate cortex whose responses track these three variables. These neurons multiplexed prediction-related variables with a distinct and explicit representation of the future position of the prey. Our results provide a clear demonstration that the brain can explicitly represent future predictions and highlight the critical role of anterior cingulate cortex for future-oriented cognition.

Neuroscience: Reevaluating the Role of Orbitofrontal Cortex.

A new optogenetic lesion study shows that the orbitofrontal cortex is essential for integrating information about recent rewards - which may either increase or decrease demand for more - with learned preferences to drive behavior.

Economic Choice as an Untangling of Options into Actions.

We propose that economic choice can be understood as a gradual transformation from a domain of options to one of the actions. We draw an analogy with the idea of untangling information in the form vision system and propose that form vision and economic choice may be two aspects of a larger process that sculpts actions based on sensory inputs. From this viewpoint, choice results from the accumulated effect of repetitions of simple computations. These may consist primarily of relative valuations (evaluations relative to the value of rejection, perhaps in a manner akin to divisive normalization) applied to individual offers. With regard to economic choice, cortical brain regions differ primarily in their position and in what information they prioritize, and do not-with a few exceptions-have categorically distinct roles. Each region's specific contribution is determined largely by its inputs; thus, understanding connectivity is crucial for understanding choice. This view suggests that there is no single site of choice, that there is no meaningful distinction between pre- and post-decisionality, and that there is no explicit representation of value in the brain.