1.
Chem Biodivers
; 20(4): e202300100, 2023 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36930226
RESUMO
'On Water'-promoted the three-component tandem Michael addition/D-A cycloaddition reaction in 80 °C at 3â h has been developed without employing any catalyst and organic solvent. The process allows facile access to polycyclic N-heterocycles derivatives contain indole and maleimide from easily accessible starting materials in moderate to high yields (up to 91 %). Compared with conventional reaction conditions, this reaction not only improves the reaction efficiency and rate but also minimizes the side reaction.